Epsametostat

Main research objectives: 1) To quantitatively analyze the total radioactivity in the excreta of male healthy subjects after a single oral administration of [14C]HH2853, and obtain the total recovery rate of human radioactivity, excretion data and main excretion pathways; 2) To quantitatively analyze the total radioactivity in whole blood and plasma of male healthy subjects after a single oral administration of [14C]HH2853, obtain the pharmacokinetic parameters of total radioactivity in whole blood (if applicable) and plasma, and investigate the distribution of total radioactivity in whole blood and plasma; 3) To quantitatively analyze the radioactive metabolite spectrum of human plasma, urine and feces of male healthy subjects after a single oral administration of [14C]HH2853, identify the main metabolites, and determine the metabolic pathway of HH2853 in the human body. Secondary study objectives: 1) To quantitatively analyze the concentration of HH2853 and its metabolites (if applicable) in plasma using a validated method and obtain the pharmacokinetic parameters of HH2853 and its metabolites (if applicable) in plasma; 2) To observe the safety of [14C]HH2853 after a single oral administration in healthy male subjects.