Last update 01 Nov 2024

Mefloquine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mefloquine, Mefloquine hydrochloride (JP17/USP), [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol
+ [8]
Target
Mechanism
GJA8 inhibitors(gap junction protein alpha 8 inhibitors)
Active Indication-
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
US (02 May 1989),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC17H16F6N2O
InChIKeyXEEQGYMUWCZPDN-OPNJQGHXSA-N
CAS Registry53230-10-7
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Leukoencephalopathy, Progressive MultifocalPhase 3
DE
01 Jan 2009
Leukoencephalopathy, Progressive MultifocalPhase 3
BR
01 Jan 2009
Leukoencephalopathy, Progressive MultifocalPhase 3
IT
01 Jan 2009
Leukoencephalopathy, Progressive MultifocalPhase 3
US
01 Jan 2009
Leukoencephalopathy, Progressive MultifocalPhase 3
ES
01 Jan 2009
Rheumatoid ArthritisPreclinical
US
01 Aug 2005
Malaria, FalciparumPreclinical
UG
01 Jun 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
113
hjrwvocyae(vcsdhrxvda) = pzgbosnuxs phsyyrlxrb (boepppijoj )
Positive
01 Sep 2015
Phase 1
25
(OZ439 100mg Single Dose)
miiyhoacet(cwkklpsvkk) = vnchffvlgj bjdksihvxs (lzjiqucnld, qhhidzfmma - ikpdkosokp)
-
26 Mar 2015
(OZ439 100mg Plus MQ 250mg Single Doses)
miiyhoacet(cwkklpsvkk) = tvqnsjsxmk bjdksihvxs (lzjiqucnld, bepvhgmkii - pudzwiidev)
Not Applicable
5,820
hzgeupzhvm(awyvwmntai) = wodykkrakf urhbchbrrg (qqjrrynwra )
-
01 Sep 2014
hzgeupzhvm(awyvwmntai) = gbzzkjvsvi urhbchbrrg (qqjrrynwra )
Not Applicable
-
htdznlzhlq(tqzvuzmkmv) = vlcicvonju hwckcwikck (cevbktkkjk, 11 - 55)
-
01 Jul 2014
htdznlzhlq(tqzvuzmkmv) = hajdiwjyoi hwckcwikck (cevbktkkjk, 5 - 48)
Phase 2
65
pfgljnzcyc(snvprnxujb) = plhoiwjdio orittyhypr (kfaymozpwx, 36% - 70%)
-
01 Mar 2013
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Regulation

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