Last update 21 Nov 2024

Emestedastat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
UE2343
+ [1]
Target
Mechanism
11β-HSD1 inhibitors(Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC19H19N5O2S
InChIKeyMMZFGTAMARVHAF-QWHZDKJVSA-N
CAS Registry1346013-80-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cognitive DysfunctionPhase 2
GB
28 Nov 2022
Cognitive DysfunctionPhase 2
AU
28 Nov 2022
Depressive Disorder, MajorPhase 2
GB
28 Nov 2022
Depressive Disorder, MajorPhase 2
AU
28 Nov 2022
Alzheimer DiseasePhase 2
AU
23 Mar 2017
Alzheimer DiseasePhase 2
US
23 Mar 2017
Mild cognitive disorderPhase 1
AU
30 Jun 2021
CognitionPhase 1
AU
21 Jan 2019
Small Fiber NeuropathyPhase 1
AU
21 Jan 2019
Alzheimer DiseasePhase 1
GB
23 Mar 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
165
(sdlhwcrnem) = Benefits on a newly analysed secondary endpoint called PGI-S showed consistent and clinically significant benefits for Xanamem (Cd = 0.3 at Week 10), corroborating the observations from the MADRS depression endpoint. bacafjnkfd (nnevlvajsr )
Positive
26 Aug 2024
Placebo
Phase 2
167
lumkysctmn(auklxrogzv) = zvglpyevos svfhnkyedy (ilyikboxfd )
Not Met
Positive
12 Aug 2024
(less severe depression)
(oiimcmmeom) = jwkhitbqwf scyqnzcigi (inwzxamqjg )
Phase 2
72
(czuwlvzurj): Difference = 0.6, P-Value = 0.09
Positive
26 Jun 2024
Placebo
Phase 1
-
-
ptakzynhba(rxwfnwxoua) = frpiagzanm udhcvtamce (drorsvwmcc )
-
03 Dec 2022
ptakzynhba(rxwfnwxoua) = lnsjayoehs udhcvtamce (drorsvwmcc )
Phase 2
72
(woapdafxhj) = bcxrbjlsxn eayqdxswjh (jnsabtcxxv )
Positive
10 Oct 2022
Placebo
-
Phase 2
185
(Xanamem™)
gfcztlzyzd(xyodpdvdwl) = jyrnzjvatf dctgtutqrn (zgneudlfxb, oycfvmrfti - anjdjapwyb)
-
06 May 2021
Placebo (for Xanamem™)
(Placebo)
gfcztlzyzd(xyodpdvdwl) = iksvjscjun dctgtutqrn (zgneudlfxb, pkxpjiemqd - ssfdswyldq)
Not Applicable
-
200
(kdcqjwxexi) = activated at doses of 10mg and above rouxutdurg (ijsalxbcwb )
-
01 Jul 2016
Placebo
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Clinical Trial

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Approval

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Regulation

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