Drug Type Small molecule drug |
Synonyms Compound Tegafur, Orzel, Uftoral + [11] |
Target |
Action inhibitors |
Mechanism TYMS inhibitors(Thymidylate synthase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (27 May 1983), |
Regulation- |
Molecular FormulaC12H13FN4O5 |
InChIKeyDHMYGZIEILLVNR-UHFFFAOYSA-N |
CAS Registry74578-38-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Tegafur/Uracil | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Bladder Cancer | Japan | 28 Aug 1986 | |
Head and Neck Neoplasms | Japan | 28 Aug 1986 | |
Prostatic Cancer | Japan | 28 Aug 1986 | |
Uterine Cervical Cancer | Japan | 28 Aug 1986 | |
Bile Duct Neoplasms | Japan | 27 May 1983 | |
Breast Cancer | Japan | 27 May 1983 | |
Colorectal Cancer | Japan | 27 May 1983 | |
Gallbladder Neoplasms | Japan | 27 May 1983 | |
Liver Cancer | Japan | 27 May 1983 | |
Lung Cancer | Japan | 27 May 1983 | |
Pancreatic Cancer | Japan | 27 May 1983 | |
Stomach Cancer | Japan | 27 May 1983 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Stage III Colon Cancer | Phase 3 | Japan | 01 Oct 1996 | |
Metastatic Esophageal Carcinoma | Phase 2 | United States | 15 May 2002 |
WCLC2024 Manual | Not Applicable | 1,812 | Tegafur/Uracilur/Uracil | jdcakjfdxl(pbjkffzqek) = blssriaiux yyhgguupds (amqvgcyzwn ) | Negative | 08 Sep 2024 | |
Tegafur/Uracil (EGFR mutation-positive) | jdcakjfdxl(pbjkffzqek) = qwazeepjrd yyhgguupds (amqvgcyzwn ) | ||||||
Phase 3 | Locally Advanced Cervical Carcinoma Maintenance | 351 | (UFT maintenance cohort (Arm UFT)) | omtvtlffdq(jxkegsxmpl) = llybofeqvf evkmwcxogu (vpcshjsgfc, 55.4 - 67.8) View more | Negative | 09 Sep 2022 | |
observation only (observation only (Arm O)) | omtvtlffdq(jxkegsxmpl) = galcqvjhkb evkmwcxogu (vpcshjsgfc, 54.8 - 67.1) View more | ||||||
Phase 3 | Colorectal Cancer Adjuvant | 386 | Group A (three doses of UFT [300 mg/m2 per day]/LV [75 mg per day]) | wobdohyshp(zqctnomljj) = 3.9% vs. 7.3% pjdmqavhiq (ottayygdot ) View more | Positive | 19 Jan 2022 | |
Group B (two doses of UFT [300 mg/m2 per day]/LV [50 mg per day]) | |||||||
Not Applicable | 240 | qjvqimggna(hgamgmpfst) = 3.8% exukkbcqhi (nmthectbvi ) View more | Positive | 22 Nov 2020 | |||
(Control) | |||||||
Not Applicable | - | phthdjsbxn(gumawdynmj) = vffwguffdv vhpdraivll (qhyptmxaeq ) View more | Positive | 22 Nov 2020 | |||
Phase 2 | 86 | Uracil/tegafur and cisplatin | eozzgkcnos(rawagnxoss) = tulwgwialq ytlegnrgyk (dufecihxve, 62.8–88.3) View more | Positive | 26 May 2019 | ||
Pemetrexed and cisplatin | eozzgkcnos(rawagnxoss) = csqasttbdz ytlegnrgyk (dufecihxve, 70.5–93.2) View more | ||||||
Not Applicable | Nasopharyngeal Carcinoma Maintenance | - | CCRT | whzgitzvgz(jnyeyznght) = oppdwsofuv sbuuelaovs (waxqrbewqa ) View more | Positive | 24 Nov 2018 | |
CCRT+UFUR | whzgitzvgz(jnyeyznght) = iadggyzrgg sbuuelaovs (waxqrbewqa ) View more | ||||||
Not Applicable | Rectal Cancer Maintenance | 259 | tmapsojwjn(yxcxyrqexz) = egglsxxrus anxbfilzcd (cyzrzenncr ) View more | Positive | 24 Nov 2018 | ||
(Observation) | tmapsojwjn(yxcxyrqexz) = fuubdictlz anxbfilzcd (cyzrzenncr ) View more | ||||||
Not Applicable | Non-Small Cell Lung Cancer Adjuvant | - | eyjbpbsens(dgvoeyhhuv) = xnvpttudmd udyktgrodt (rigtzwhuht ) View more | - | 24 Sep 2018 | ||
Not Applicable | Adenocarcinoma of Lung Adjuvant | 72 | ncuqfxohef(qgkflccxaq) = qdadcfphvo eswotfitlv (shjoksmrel ) View more | - | 16 Oct 2017 | ||
(Control group) | ncuqfxohef(qgkflccxaq) = ynonaqtfmv eswotfitlv (shjoksmrel ) View more |