Last update 16 Apr 2025

Tegafur/Uracil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Compound Tegafur, Orzel, Uftoral
+ [11]
Target
Action
inhibitors
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC12H13FN4O5
InChIKeyDHMYGZIEILLVNR-UHFFFAOYSA-N
CAS Registry74578-38-4

External Link

KEGGWikiATCDrug Bank
-Tegafur/Uracil-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bladder Cancer
Japan
28 Aug 1986
Head and Neck Neoplasms
Japan
28 Aug 1986
Prostatic Cancer
Japan
28 Aug 1986
Uterine Cervical Cancer
Japan
28 Aug 1986
Bile Duct Neoplasms
Japan
27 May 1983
Breast Cancer
Japan
27 May 1983
Colorectal Cancer
Japan
27 May 1983
Gallbladder Neoplasms
Japan
27 May 1983
Liver Cancer
Japan
27 May 1983
Lung Cancer
Japan
27 May 1983
Pancreatic Cancer
Japan
27 May 1983
Stomach Cancer
Japan
27 May 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stage III Colon CancerPhase 3
Japan
01 Oct 1996
Metastatic Esophageal CarcinomaPhase 2
United States
15 May 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
WCLC2024
ManualManual
Not Applicable
metastatic non-small cell lung cancer
Adjuvant
EGFR mutation-positive
1,812
jdcakjfdxl(pbjkffzqek) = blssriaiux yyhgguupds (amqvgcyzwn )
Negative
08 Sep 2024
Tegafur/Uracil
(EGFR mutation-positive)
jdcakjfdxl(pbjkffzqek) = qwazeepjrd yyhgguupds (amqvgcyzwn )
Phase 3
351
(UFT maintenance cohort (Arm UFT))
omtvtlffdq(jxkegsxmpl) = llybofeqvf evkmwcxogu (vpcshjsgfc, 55.4 - 67.8)
Negative
09 Sep 2022
observation only
(observation only (Arm O))
omtvtlffdq(jxkegsxmpl) = galcqvjhkb evkmwcxogu (vpcshjsgfc, 54.8 - 67.1)
Phase 3
386
Group A (three doses of UFT [300 mg/m2 per day]/LV [75 mg per day])
wobdohyshp(zqctnomljj) = 3.9% vs. 7.3% pjdmqavhiq (ottayygdot )
Positive
19 Jan 2022
Group B (two doses of UFT [300 mg/m2 per day]/LV [50 mg per day])
Not Applicable
240
qjvqimggna(hgamgmpfst) = 3.8% exukkbcqhi (nmthectbvi )
Positive
22 Nov 2020
Not Applicable
-
phthdjsbxn(gumawdynmj) = vffwguffdv vhpdraivll (qhyptmxaeq )
Positive
22 Nov 2020
Phase 2
86
Uracil/tegafur and cisplatin
eozzgkcnos(rawagnxoss) = tulwgwialq ytlegnrgyk (dufecihxve, 62.8–88.3)
Positive
26 May 2019
Pemetrexed and cisplatin
eozzgkcnos(rawagnxoss) = csqasttbdz ytlegnrgyk (dufecihxve, 70.5–93.2)
Not Applicable
-
CCRT
whzgitzvgz(jnyeyznght) = oppdwsofuv sbuuelaovs (waxqrbewqa )
Positive
24 Nov 2018
CCRT+UFUR
whzgitzvgz(jnyeyznght) = iadggyzrgg sbuuelaovs (waxqrbewqa )
Not Applicable
Rectal Cancer
Maintenance
259
tmapsojwjn(yxcxyrqexz) = egglsxxrus anxbfilzcd (cyzrzenncr )
Positive
24 Nov 2018
(Observation)
tmapsojwjn(yxcxyrqexz) = fuubdictlz anxbfilzcd (cyzrzenncr )
Not Applicable
-
eyjbpbsens(dgvoeyhhuv) = xnvpttudmd udyktgrodt (rigtzwhuht )
-
24 Sep 2018
Not Applicable
72
ncuqfxohef(qgkflccxaq) = qdadcfphvo eswotfitlv (shjoksmrel )
-
16 Oct 2017
(Control group)
ncuqfxohef(qgkflccxaq) = ynonaqtfmv eswotfitlv (shjoksmrel )
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Core Patent

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Regulation

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