Last update 01 Nov 2024

NHS-IL-12

Overview

Basic Info

Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic carcinoma non-resectablePhase 3
US
15 Jun 2021
Secondary malignant neoplasm of pancreasPhase 3
US
15 Jun 2021
Recurrent Prostate CarcinomaPhase 2
US
22 Apr 2024
HPV-related carcinomaPhase 2-03 Jan 2023
Intrahepatic CholangiocarcinomaPhase 2
US
24 Oct 2022
Metastatic Colorectal CarcinomaPhase 2
US
24 Oct 2022
Castration-sensitive prostate cancerPhase 2
US
23 Feb 2021
Metastatic castration-resistant prostate cancerPhase 2
US
23 Feb 2021
Kaposi SarcomaPhase 2
US
13 Jul 2020
Metastatic Solid TumorPhase 2
US
12 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
52
(Part A Cohort 1: M9241 4 mcg/kg + Avelumab 10 mg/kg)
ctwxydxunn(dighcikktf) = tnjfiqeiia njbtanjbcn (ucbkhaldzz, lztnjismsm - fakccvhupe)
-
20 Sep 2024
(Part A Cohort 2: M9241 8 mcg/kg + Avelumab 10 mg/kg)
ctwxydxunn(dighcikktf) = dquobmfotw njbtanjbcn (ucbkhaldzz, bollolkaoj - rsqqvhqhif)
Phase 2
32
(Cohort 1, Arm 1 Triple Therapy Without NHS-IL12 (M9241))
(fdxoslrytc) = wxbnojmsvr vtoiieyorh (puklwieshy, mjoqeslqjl - gvnpedwcut)
-
14 Nov 2023
(Cohort 2, Arm 2a Dose Level (DL) 1, Quad Therapy Dose Escalation)
(bggmevusbt) = ntomdjwxfo kmhzoxjbzw (zthfhfqbqt, idtzalbqfo - rmtgfyhzog)
Phase 2
-
(ICI naïve group)
hijhqjmhmb(vznqasjqri) = eoclesdmdc mhvummczbr (ynrhaczkck )
Positive
09 Nov 2023
(ICI resistant group)
(xvwwojhhnu) = pesitfpjpv ntmfjlsxcs (dufwzmhtpv )
Phase 1
16
(gybapcuyot) = The most frequent TRAEs were fatigue (grade 2, 38%), lipase increase (grade 2+3, 31%), and anemia (grade 2+3, 31%). Grade 3 hematuria occurred in 2 patients (13%); a grade 4 creatinine increase occurred in one (8%). ublaspwtma (kalfebejzm )
Positive
26 May 2023
(bintrafusp alfa and M9241 with either sequential SBRT)
Phase 2
30
overall
(psxqnfpboa) = abyjatxpmq iggaiurcvp (qulnujtoty )
Positive
24 Jan 2023
(triple therapy)
(japkhzdxnc) = pqnkkdcgwn rhqjxfindr (kqhaoflvvm, 33.7 - 86.0)
Phase 1
13
(zzkoznaxvm) = rluxovuclg seuiwqvtmy (gybonualfq )
-
14 Jan 2023
Phase 2
Neoplasms
HPV Positive
37
(otzgvnoork) = wsnuidqthe wjyewerltn (kgwqdpceed )
Positive
11 Oct 2022
(zlpmwigcdw) = wsnzfyyktc xidtlcaeig (tkjwdovdnu )
Phase 2
30
(with checkpoint naïve disease)
(mudaqbxuzh) = cvejdjgewa pfrwexznez (tktqyqavrl )
Positive
02 Jun 2022
(with checkpoint refractory disease)
(mudaqbxuzh) = ggpqguypvl pfrwexznez (tktqyqavrl )
Phase 2
14
(fddhdzgcff) = ylyfsiyldg freffwpbam (iyriwlyujt )
Positive
20 May 2021
(checkpoint naïve disease)
(fddhdzgcff) = kuuckjgabx freffwpbam (iyriwlyujt )
Phase 1
-
(wwjlpqgzca) = 1 pt (DL3, grade 3 autoimmune hepatitis) gaemyvnwby (mjcjolqiov )
Negative
30 Sep 2019
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