Marburg Virus Disease Pipeline Offers Promising New Options
17 Jun 2021
Gene TherapyAntibodyVaccineSmall molecular drugCollaborate
Los Angeles, USA, June 16, 2021 (GLOBE NEWSWIRE) -- Marburg Virus Disease Pipeline Offers Promising New Options for Treatment
Around 12+ key companies are developing the Marburg Virus Disease therapies. Bavarian Nordic is developing the MVA-BN filovirus vaccine, which is in the most advanced stage.
DelveInsight’s “Marburg Virus Disease Pipeline Insight” report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in the Marburg Virus Disease pipeline landscapes. It comprises Marburg Virus Disease pipeline drug profiles, including clinical and non-clinical stage products. It also includes the Marburg Virus Disease therapeutics assessment by product type, stage, route of administration, and molecule type and further highlights the inactive Marburg Virus Disease pipeline products.
Some of the key takeaways from the Marburg Virus Disease Pipeline Report
Get an overview of pipeline landscape @ Marburg Virus Disease Clinical Trials Analysis
Marburg Virus Disease is a highly virulent disease, which causes hemorrhagic fever. It belongs to the same family that causes Ebola virus disease. There is no particular treatment for Marburg hemorrhagic fever. Instead, supportive hospital therapy should be utilized, including balancing the patient’s fluids and electrolytes, maintaining oxygen status and blood pressure, replacing lost blood and clotting factors, and treating any complicating infections.
Marburg Virus Disease Emerging Drugs
Galidesivir (BCX4430) is a broad-spectrum antiviral in advanced development for the virus treatment. BioCryst is developing galidesivir in partnership with U.S. government agencies and other institutions. In September 2013, NIAID contracted with BioCryst to develop galidesivir to treat Marburg Virus Disease and potentially for other filoviruses, including the Ebola virus. The drug is currently in phase 1 of clinical trials for the treatment of Marburg Virus Disease.
Research and Development Phase I NCT03800173: BioCryst Pharmaceuticals, in December 2018, initiated “A Phase 1 Double-blind, Placebo Controlled, Dose Ranging Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Galidesivir (BCX4430) Administered as Single Doses Via Intravenous Infusion in Healthy Subjects”. This is a placebo-controlled, randomized, double-blind study to evaluate the pharmacokinetics of galidesivir following administration of single doses by IV infusion. This single ascending dose study will assess the safety, tolerability, and PK of single doses of galidesivir vs. placebo administered as IV infusions in healthy subjects enrolled in up to four dose cohorts of 8 subjects each. A single dose of study drug will be administered per cohort: 6 subjects will receive galidesivir IV, and two subjects will receive matching placebo. The trial got completed in April 2019 with 32 enrolled participants.
Results
MVA-BN Filo is a multivalent vaccine candidate designed to protect against the most common causes of viral hemorrhagic fever; Ebola and the Marburg virus. While several sub-types of Ebola are known, the vaccine targets the Zaire and Sudan strains, which are considered the most important from a public health perspective in addition various. It is currently in phase 2 of clinical trials for the treatment of Marburg Virus Disease.
cAd3-Marburg, also known as VRC MARADC087 00 VP, is being developed and investigated by Albert B. Sabin Vaccine Institute, ICON plc, and Oklahoma Blood Institute in Phase I stage of development for the treatment of patients with Marburg virus disease.
Research and Development Phase INCT04723602: In January 2021, a trial was initiated by ICON plc in collaboration with Sabin vaccine institute titled “Phase 1b Trial to Evaluate Safety, Tolerability and Immune Responses of 2 Monovalent Chimpanzee Adenoviral Vectored Filovirus (Ebola-S and Marburg) Vaccines to Healthy Adults, Collection of Plasma/Serum for the Purposes of Assay Development”. The primary objective is to evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults. The trial is anticipated to get completed in December 2021 with an estimated enrollment of 32 participants.
For further information, refer to the detailed report @ Marburg Virus Disease Pipeline Therapeutics
Scope of Marburg Virus Disease Pipeline Drug Insight
· Marburg Virus Disease Therapies Late-stage (Phase III) · Marburg Virus Disease Therapies Mid-stage (Phase II)· Marburg Virus Disease Therapies Early-stage (Phase I) · Marburg Virus Disease Pre-clinical stage and Discovery candidates · Discontinued and Inactive candidates
· RNA replicase inhibitors· Immunostimulants· Virus replication inhibitors
· Peptides· Monoclonal Antibody· Polymer· Small molecule· Gene therapy
· Oral· Parenteral· Intravenous· Subcutaneous· Topical
· Monotherapy· Combination· Mono/Combination
Key Questions regarding Current Marburg Virus Disease Treatment Landscape and Emerging Therapies Answered in the Pipeline Report
Table of Contents
Get a customized pipeline report @ Marburg Virus Disease Drugs Pipeline Report
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