Delving into the Latest Updates on Shenzhen Zhongke Ai Shen Pharmaceutical Co Ltd with Synapse

Overview

Tags

Neoplasms

Digestive System Disorders

Other Diseases

Biological products

Antibody

Oligonucleotide

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	6

Top 5 Drug Type	Count

Biological products	4
Antibody	2
Oligonucleotide	1
Biosimilar	1

Top 5 Target	Count

TNFAIP8L2(TNF alpha induced protein 8 like 2)	1
PD-1(Programmed cell death protein 1)	1
TRAIL(Tumor necrosis factor ligand superfamily member 10)	1
c-Rel(REL proto-oncogene, NF-kB subunit)	1

主要目的：评价注射用AS1501在中国健康受试者中单次静脉注射给药的耐受性和安全性，为后期临床研究推荐合理的给药方案；次要目的：（1）评价注射用AS1501在中国健康受试者中的药代动力学特征；（2）评价注射用AS1501在中国健康受试者中的免疫原性；探索性目的：初步探索注射用AS1501静脉注射给药前后血清中TRAIL表达水平的变化。

[Translation]

Main purpose: To evaluate the tolerability and safety of a single intravenous injection of AS1501 for injection in healthy Chinese subjects, and to recommend a reasonable dosing regimen for later clinical studies; Secondary purpose: (1) To evaluate the pharmacokinetic characteristics of AS1501 for injection in healthy Chinese subjects; (2) To evaluate the immunogenicity of AS1501 for injection in healthy Chinese subjects; Exploratory purpose: To preliminarily explore the changes in serum TRAIL expression levels before and after intravenous injection of AS1501 for injection.

Start Date27 Jun 2022

Sponsor / Collaborator

Shenzhen Zhongke Ai Shen Pharmaceutical Co Ltd

100 Clinical Results associated with Shenzhen Zhongke Ai Shen Pharmaceutical Co Ltd

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0 Patents (Medical) associated with Shenzhen Zhongke Ai Shen Pharmaceutical Co Ltd

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100 Deals associated with Shenzhen Zhongke Ai Shen Pharmaceutical Co Ltd

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100 Translational Medicine associated with Shenzhen Zhongke Ai Shen Pharmaceutical Co Ltd

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

4

Preclinical

Phase 1 Clinical

1

Phase 2 Clinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

AS-1601 ( PD-1 )	Neoplasms More	Phase 2
AS-1501 ( TRAIL )	liver function failure More	Phase 1
BS01(shenzhen zhongke amshen pharmaceutical)	Neoplasms More	Preclinical
AS1801	Inflammation More	Preclinical
AS1701 ( c-Rel )	Neoplasms More	Preclinical