Maastricht University

BERLIN, GERMANY / ACCESSWIRE / April 3, 2024 / Berlin Cures, a biotechnology company in Phase II clinical trial for a treatment against Long COVID, appoints six distinguished scientists to a new advisory board. The aim of the board is to advise on industry developments and new growth potentials, as well as to support research and development that will further strengthen the portfolio of Berlin Cures and thus the successful market launch of new therapies. The new board includes the following scientists: Prof. Friedemann Paul , neuroimmunologist and Vice Dean at the Charité in Berlin; Prof. Stephane Heymans , Professor of Cardiomyopathy and Head of the Centre for Heart Failure Research at Maastricht University; Prof. Carl Erb , ophthalmologist in Berlin specializing in glaucoma and neuroprotective research; Prof. John McMurray , Professor of Medical Cardiology at the University of Glasgow, focusing on heart failure and the cardiovascular consequences of diabetes and chronic kidney disease, recipient of the OBE and the ESC Gold Medal; Prof. Carmen Scheibenbogen , immunologist at the Charité Berlin, focusing on ME/CFS and Long COVID; and Prof. Christian Mardin , ophthalmologist at the University Hospital Erlangen, specializing in glaucoma research and biomarkers for Long COVID and autoimmune diseases. "We are very pleased to now work with six renowned scientists who have achieved great success in their respective fields of research. Their expertise will significantly accelerate our mission to develop groundbreaking therapies for various diseases. Berlin Cures has been known for innovative and effective research for years. With our platform technology, we aim to provide effective therapies for the treatment of diseases associated with functional autoantibodies, including Long COVID, heart failure, glaucoma, and ME/CFS," says Oliver von Stein, CEO of Berlin Cures . Berlin Cures, a biotechnology company specializing in the neutralization of functional autoantibodies (fAABs), is currently conducting a Phase II clinical trial for its drug BC 007 for Long COVID. The study, which began in June 2023, is being conducted in five countries and 12 study centers. Over 75% of the targeted 114 patients have already been enrolled in the study. The study results, expected in autumn 2024, will pave the way for the next phase of development: Berlin Cures is actively engaged in fundraising to capitalize on future opportunities to support a Phase III study necessary for regulatory approval and to advance the clinical development of other programs. Biographies of the new advisory board members can be found here . Recruiting study centers can be found here . About Berlin Cures: The Berlin Cures team has dedicated over two decades to the research of functional autoantibodies (fAABs) and has successfully identified a molecule capable of effectively neutralizing these. Promising preclinical results have been observed for BC 007. In a recently completed Phase IIa trial with patients with chronic heart failure, BC 007 demonstrated long-term autoantibody neutralization after a single dose resulting in significant improvement in cardiac function, with no spontaneous disappearance of autoantibodies in untreated patients. Its potential as an effective therapy for Long COVID was realized when tests on sera from Long COVID patients proved positive for fAABs, supported by clinical observations in four case studies. By addressing the underlying cause of fAAB-associated diseases with this unique biotechnology, Berlin Cures emerges as one of the pioneering entities committed to addressing this critical issue at its core. Since June 2023, Berlin Cures has been absolving a Phase II clinical trial with BC 007 in the indication Long COVID, an acute and escalating global health problem, to obtain meaningful and robust results on efficacy and tolerability of BC 007 with patients suffering from Long COVID. Contact: FGS Global E-Mail: berlincures-eu@fgsglobal.com SOURCE: Berlin Cures Holding AG View the original press release on accesswire.com

Proposal to appoint Ms. Hanneman as member of Philips’ Board of Management fulfilling the role of CFO per October 1, 2024 Amsterdam, the Netherlands – Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today announced the proposal to appoint Charlotte Hanneman as member of the Board of Management, fulfilling the role of Chief Financial Officer (CFO), effective October 1, 2024. The proposal will be submitted to the Annual General Meeting of Shareholders (AGM), to be held on May 7, 2024. Ms. Hanneman will join Philips as a member of Philips’ Executive Committee on June 1, 2024, to start her induction and transition into the role, succeeding current CFO Abhijit Bhattacharya on October 1, 2024. Mr. Bhattacharya has been CFO and member of Philips’ Board of Management and Executive Committee since 2015 and will retire from the company after a successful 37-year career on September 30, 2024. Ms. Hanneman (Dutch, 1978) will join Philips with over 20 years’ experience in the MedTech and pharmaceutical industries, most recently as Controller and Head of Financial Planning & Analysis at global medical technology company Stryker. In this current role, she is responsible for financial control, enterprise financial planning and analysis, and business development finance. She is also responsible for indirect procurement, and directly responsible for the finance teams across Europe, Middle East and Africa, Canada, and Latin America. Prior to this, she held several international finance leadership roles at Stryker, and other multinational healthcare companies, including Merck, Schering-Plough and Organon. Ms. Hanneman has extensive experience working in the US and has lived in various countries across Asia and Europe. She holds a master’s degree in economics and an executive master of finance and control from Maastricht University, the Netherlands. Roy Jakobs, CEO of Royal Philips said: “I would like to thank Abhijit for his significant contribution to the transformation of Philips into a health technology company. His dedication and leadership have made a major impact throughout his long 37-year career in the company. In the future, I will miss him for his character and the insight he brought to the boardroom, however, he will remain our CFO until the end of September, ensuring a smooth transition. On behalf of Philips’ Executive Committee, I wish him all the best in his future endeavors.” “This is an exciting time for Charlotte to join Philips. Her strong MedTech and pharma knowledge spanning Europe, Asia, and the US, as well as her extensive finance experience, coupled with her energy and passion for the healthcare industry, make her an ideal fit for the role.” Charlotte Hanneman, incoming CFO of Royal Philips, added: “Philips is on an exciting journey to create value with sustainable impact. With its global reach, market leadership positions, and patient- and people-focused innovation, Philips is well positioned to help deliver real change across healthcare. I am looking forward to joining the team to drive impact and continue to deliver on the plans and commitments set for the future.” Feike Sijbesma, Chairman of Philips’ Supervisory Board, said: “On behalf of the Supervisory Board, I would like to thank Abhijit for all he has done for Philips over a long and illustrious career with the company and wish him the very best for the future. In welcoming Charlotte, we are broadening the diversity of the Board of Management while further deepening the industry expertise of the team to help drive the plan to create value with sustainable impact.” Abhijit Bhattacharya, CFO of Royal Philips commented: “After serving Philips and leading great teams for many years, helping to shape the future of the company, the time is right for me to retire from the company in September. I am fully focused on delivering on Philips’ plan in the next six months and ensuring a seamless handover to Charlotte.” Additional information on Philips’ Board of Management and Executive Committee can be found here. Philips External Relations Steve Klink Tel.: +31 6 1088 8824 E-mail: steve.klink@philips.com Philips Investor Relations Leandro Mazzoni Tel.: +31 20 5977055 E-mail: leandro.mazzoni@philips.com About Royal Philips Royal Philips (NYSE: PHG, AEX: PHIA) is a leading health technology company focused on improving people’s health and well-being through meaningful innovation. Philips’ patient- and people-centric innovation leverages advanced technology and deep clinical and consumer insights to deliver personal health solutions for consumers and professional health solutions for healthcare providers and their patients in the hospital and the home. Headquartered in the Netherlands, the company is a leader in diagnostic imaging, ultrasound, image-guided therapy, monitoring and enterprise informatics, as well as in personal health. Philips generated 2023 sales of EUR 18.2 billion and employs approximately 69,700 employees with sales and services in more than 100 countries. News about Philips can be found at . Forward-looking statements This release contains certain forward-looking statements with respect to the financial condition, results of operations and business of Philips and certain of the plans and objectives of Philips with respect to these items. Examples of forward-looking statements include statements made about the strategy, estimates of sales growth, future EBITA, future developments in Philips’ organic business and the completion of acquisitions and divestments. By their nature, these statements involve risk and uncertainty because they relate to future events and circumstances and there are many factors that could cause actual results and developments to differ materially from those expressed or implied by these statements. This press release contains inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation. Attachments Charlotte Hanneman Abhijit Bhattacharya

GELEEN, Netherlands, Jan. 30, 2024 /PRNewswire/ -- Matisse Pharmaceuticals B.V., a clinical stage company developing a medicinal product for the treatment of sepsis, today announced topline results from the HistoSeps trial evaluating the safety, tolerability and pharmacokinetics of intravenously (IV) administered M6229 in critically ill sepsis patients. According to the WHO, sepsis is the leading cause of death. Currently, there is no effective treatment against sepsis. Matisse's platform technology is based on the discovery that in most patients suffering from sepsis, proteins called histones are released by the innate immune system and apoptotic and/or necrotic cells into the blood stream, where they are toxic to other cells. Due to this self-enforcing cascade, people may die from organ failure within one or two days. Preclinical results have shown that by neutralizing the toxic histones with Matisse's product M6229, the negative cascade is inhibited by neutralization of cationic histones by highly anionic M6229. In this first in human clinical study, performed at the intensive care unit (ICU) of the Amsterdam University Medical Center, in total 10 critically ill patients in ICU setting received a six-hour IV infusion of M6229. This study met its primary objectives, showing favorable safety and tolerability as well as close to dose-proportional pharmacokinetics of IV administered M6229 in critically ill patients with sepsis. Preliminary semi-quantitative plasma histone H3 (H3) analysis executed by the University of Maastricht, showed a pharmacodynamic effect of M6229 by assessing plasma levels of extracellular histones in the study patients, before and at different time-points after M6229 administration. A decrease in SOFA (Sequential Organ Failure Assessment) score was found for 70% of the patients following the three days after the infusion day. Further quantitative analyses on plasma histones H3 and H2b are ongoing. Based on available data, it is concluded that the treatment infusion with M6229 should be started as soon as possible after patients are diagnosed with sepsis to be most effective. Matisse Pharmaceuticals is preparing for a Phase IIb clinical study in which critically ill sepsis patients will receive an IV infusion which should last until discharge from ICU, or organ support free for 24h, or severe adverse events, or the maximum allowed duration of infusion is reached. The recently closed funding round will allow Matisse to effectively continue its preparation for the large scale phase IIb study in sepsis patients. In the course of 2024, Matisse aims to conclude an additional funding round which should cover the full execution of the phase IIb clinical trial, the production scale up to a commercial level and to progress on a number of R&D projects, thereby also further strengthening the organization. "We are very pleased with the results confirming strong progress in the development of our lead compound M6229, as the first effective treatment for sepsis. The current data give strong guidance to us in the design of a successful phase 2b study, which we expect to run in the US and Europe," according to Kees Groen, Chief Development Officer at Matisse Pharmaceuticals. About M6229 Matisse claims to have identified an elegant solution for treating sepsis by using its lead compound M6229 to neutralize toxic circulatory histones. Matisse's platform technology is based on the discovery that in most patients suffering from sepsis, proteins called histones are released by the innate immune system and apoptotic and/or necrotic cells into the blood stream, where they are toxic to other cells. Due to this self-enforcing cascade, people may die from organ failure within one or two days. Preclinical results have shown that by neutralizing the toxic histones with Matisse's product M6229, the negative cascade is inhibited by neutralization of cationic histones by highly anionic M6229. Currently, there is no effective treatment against sepsis. According to the WHO, sepsis is the leading cause of death. From the 49 million patients globally suffering from sepsis every year, more than 20% die. According to a study by Buchman et al., published in the Journal of Critical Care Medicine, sepsis is the most common cause of in-hospital deaths, costing over $62 billion annually in the USA alone. About Matisse Pharmaceuticals Matisse Pharmaceuticals BV was founded in 2014 in Geleen, the Netherlands. Matisse targets life-threatening inflammation by neutralizing cytotoxic components of the inflammatory system. Its main development program is the development of a medicine to fight sepsis and septic shock. This study has been financed by the Dutch Ministry of Economic Affairs by means of the PPP Allowance made available by the Top Sector Life Sciences & Health to stimulate public-private partnerships. Logo: SOURCE Matisse Pharmaceuticals B.V.