Delving into the Latest Updates on Ferndale Laboratories, Inc. with Synapse

Overview

To determine the efficacy (measured at 12 weeks) of DerMend Moisturizing Bruise Formula in improving the appearance of bruising and reducing the appearance of photoaging of the forearms and hands in mature skin. Assessments will be made through ongoing objective measurements and clinical ratings.
To confirm the safety (local tolerance) of DerMend Moisturizing Bruise Formula.

Start Date01 Jul 2013

Sponsor / Collaborator

Center For Clinical & Cosmetic Research

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NCT01746056 / CompletedNot ApplicableIIT

A Comparative Study of Occlusive Heat Patch Vs. No Treatment in the Treatment of Verruca

The goal of this study is to determine the safety and efficacy of the occlusive heat patch for the treatment of verrucae (warts).

Start Date01 Dec 2012

Sponsor / Collaborator

Yale University

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100 Clinical Results associated with Ferndale Laboratories, Inc.

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0 Patents (Medical) associated with Ferndale Laboratories, Inc.

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3

Literatures (Medical) associated with Ferndale Laboratories, Inc.

01 Jan 2022·Nutrition, Metabolism and Cardiovascular Diseases

Corrigendum to “Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism” [Nutr Metabol Cardiovasc Dis 31 (2021) 2490–2703]

Author: Oniciu, Daniela ; Adeli, Khosrow ; Newton, Roger S ; Srivastava, Rai Ajit K ; Hurley, Timothy R

01 Jul 2021·Nutrition, Metabolism and Cardiovascular DiseasesQ3 · MEDICINE

Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism

Q3 · MEDICINE

Article

Author: Oniciu, Daniela ; Adeli, Khosrow ; Newton, Roger S ; Hurley, Timothy R ; Srivastava, Rai Ajit K

BACKGROUND AND AIMSCholesterol and triglycerides are risk factors for developing cardiovascular disease. Therefore, appropriate cells and assays are required to discover and develop dual cholesterol and fatty acid inhibitors. A predictive hyperlipidemic animal model is needed to evaluate mechanism of action of lead molecule for therapeutic indications.METHODS AND RESULTSPrimary hepatocytes from rat, hamster, rabbit, and humans were compared for suitability to screen compounds by de novo lipogenesis (DNL) using¹⁴C-acetate. Hyperlipidemic hamsters were used to evaluate efficacy and mode of action. In rat hepatocytes DNL assay, both the central moiety and carbon chain length influenced the potency of lipogenesis inhibition. In hyperlipidemic hamsters, ETC-1002 decreased plasma cholesterol and triglycerides by 41% and 49% at the 30 mg/kg dose. Concomitant decreases in non-esterified fatty acids (-34%) and increases in ketone bodies (20%) were associated with induction of hepatic CPT1-α. Reductions in proatherogenic VLDL-C and LDL-C (-71% and -64%) occurred partly through down-regulation of DGAT2 and up-regulation of LPL and PDK4. Activation of PLIN1 and PDK4 dampened adipogenesis and showed inverse correlation with adipose mass. Hepatic concentrations of cholesteryl ester and TG decreased by 67% and 64%, respectively. Body weight decreased with concomitant decreases in epididymal fat. Plasma and liver concentrations of ETC-1002 agreed with the observed dose-response efficacy.CONCLUSIONSTaken together, ETC-1002 reduced proatherogenic lipoproteins, hepatic lipids and adipose tissues in hyperlipidemic hamsters via induction of LPL, CPT1-α, PDK4, and PLIN1, and downregulation of DGAT2. These characteristics may be useful in the treatment of fatty livers that causes non-alcoholic steatohepatitis.

01 Aug 1999·Microscopy and Microanalysis

In Vitro Investigation of the Synthetic Sebum Adsorbing Efficacy of Acrylate Copolymer as an Excipient And In Clinac ™ Oc

Author: Smith, Christine ; Taylor, R. W. ; White, M ; White, M. ; Taylor, R W

AbstractWhile sebum provides several functions in the integument, there is considerable interest in the control of excess sebum on the human skin. The primary function of sebum is to lubricate and waterproof the stratum cornenum layer, in addition to preventing hair from becoming brittle. In several cases, the secretion of sebum is inhibited as a result of blockage of the drainage pathway for the sebaceous glands which may result in abnormal skin conduction (1,2). Clinac™ OC (Oil Control) has been developed with a special oil adsorbing polymer, DVB/lsobornyl Methacrylate/Lautyl Methacrylate Copolymer (3). This particular copolymer posses the capacity to adsorb oils because of its high affinity for hydrophobic nonpolar substances. The purpose of this investigation is to show the adsorptive capacity of the acrylate copolymer in Clinac™ OC preparation and in buffer.The acrylate polymer was incubated in artificial sebum for 4 hrs and 8 hrs at 37 C.

100 Deals associated with Ferndale Laboratories, Inc.

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100 Translational Medicine associated with Ferndale Laboratories, Inc.

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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