A Prospective, Single-center, Blinded, Randomized, Split-face Study Evaluating the Spread of PrabotulinumtoxinA-xvfs Versus OnabotulinumtoxinA in the Treatment of Forehead Rhytides

Ten subjects will be enrolled in the study. Each subject will have their left and right forehead randomly assigned to receive 4 units of PrabotulinumtoxinA-xvfs or OnabotulinumtoxinA. Subjects will be reassessed at 2 weeks for evaluation of rhytide diminution around each injection point to assess relative diffusion of each drug in the forehead.

Start Date01 May 2023

Sponsor / Collaborator

Lupo Center For Aesthetic & General Dermatology, L L C

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100 Clinical Results associated with Lupo Center For Aesthetic & General Dermatology, L L C

0 Patents (Medical) associated with Lupo Center For Aesthetic & General Dermatology, L L C

Literatures (Medical) associated with Lupo Center For Aesthetic & General Dermatology, L L C

01 Jan 2024·Dermatologic Surgery

Alternating Treatment With Nonablative Fractional Laser and Radiofrequency Microneedling for the Treatment of Acne Scars: A Prospective, Randomized, Split-Face Study

Article

Author: Loyal, Jameson ; Borsack, Summer ; Goldman, Mitchel ; Hartman, Nina

BACKGROUNDAcne scarring is an unfortunate sequela affecting up to 95% of patients with acne and carries profound psychosocial impact. Both nonablative fractional lasers (NAFL) and microneedling with radiofrequency (MNRF) have demonstrated comparable efficacy in the treatment of atrophic acne scars.OBJECTIVETo determine whether alternating NAFL and MNRF is superior to NAFL alone in the treatment of atrophic acne scars.METHODS AND MATERIALSThis was a prospective, single-center, double-blinded, split-face clinical trial. Twenty patients with atrophic acne scars who had their facial halves randomized to receive either NAFL alone or NAFL alternating with MNRF. Patients received 4 total treatments at 4-week intervals.RESULTSNinety days after the final treatment, both facial halves demonstrated a significant improvement in the mean global échelle d'évaluation clinique des cicatrices d'acné (ECCA) score from baseline (p < .001 for both halves). The average percentage improvement at the final end point was 20% to 30% from baseline. No significant difference was noted between facial halves for mean global ECCA score or percentage improvement at any time point.CONCLUSIONAlthough both NAFL and MNRF are safe and effective in the treatment of atrophic acne scars, alternating NAFL and MNRF does not seem to be superior to NAFL alone.

01 Apr 2023·Dermatologic Surgery

Collagenase Clostridium Histolyticum-aaes Injections for Volumetric Change of Cellulite Dimples and Gluteal Contouring

Article

Author: Fabi, Sabrina G. ; Hartman, Nina N. ; Wood, Emily S. ; Almukhtar, Rawaa M.

BACKGROUNDCollagenase clostridium histolyticum-aaes (CCH) is approved for the treatment of moderate-to-severe cellulite.OBJECTIVEThis is a retrospective image review of subjects previously enrolled in Cohort 2 of the EN3835-305 trial to determine the effects of CCH on volumetric changes of cellulite dimples and overall gluteal contouring.METHODSIn this retrospective analysis, photographs from Day 90 and Day 180 were superimposed on baseline images and the volumetric change of each treated cellulite dimple was quantified. Side-by-side photographs of the buttocks were also evaluated for change in gluteal contour using the Physician Global Aesthetic Improvement Scale (PGAIS).RESULTSFifty-eight female subjects and 403 cellulite dimples were evaluated. Three-dimensional imaging analysis revealed a significant improvement in total negative dimple volume at both Day 90 and Day 180 of 27% and 26%, respectively (p < .001 and p = .002, respectively). At Day 90, the overall gluteal contour, as signified by the mean PGAIS among the 3 blinded dermatologists, was rated as +1 (improved) in 27% (n = 17) of the subjects. At Day 180, the mean PGAIS was +1 (improved) or +2 (very much improved) in 39% (n = 26) of the subjects.CONCLUSIONCHH is an effective tool for treating cellulite dimples and improving gluteal contour.

01 Apr 2023·Dermatologic Surgery

A Randomized, Single-Center, Double-Blinded, Split-Body Clinical Trial of Poly-l-Lactic Acid for the Treatment of Cellulite of the Buttocks and Thighs

Article

Author: Fabi, Sabrina G. ; Almukhtar, Rawaa M. ; Hartman, Nina ; Wood, Emily S. ; Loyal, Jameson

BACKGROUNDMore than 90% of women report concerns of cellulite on their skin. Poly-l lactic acid (PLLA-SCA) is a biocompatible, semipermanent, synthetic filler that induces neocollagenesis.OBJECTIVETo investigate the safety and efficacy of PLLA-SCA for the treatment of cellulite of the buttock and thigh regions.METHODSThis was a prospective, single-center, double-blinded, split-body, clinical trial of 20 women with slight to moderate skin laxity of the buttocks and/or thighs contributing to mild-to-moderate cellulite. Each subject’s buttocks and thighs were randomized to receive injections with up to 2 vials of PLLA-SCA or the equivalent volume of bacteriostatic water per treatment area. Subjects received at total of 3 treatments 4 weeks apart and were followed for 330 days.RESULTSTreatment of the buttocks with PLLA-SCA resulted in significant reduction of depression depth, improvement in the morphological appearance of the skin, improvement in the grade of skin laxity, and overall improvement in cellulite appearance. Treated thighs showed reduction in the depth and number of depressions and an improvement in overall cellulite appearance. No significant procedure side effects were found.CONCLUSIONPoly-l lactic acid offers an effective and safe method for treating cellulite of the buttocks and thighs.

100 Deals associated with Lupo Center For Aesthetic & General Dermatology, L L C

100 Translational Medicine associated with Lupo Center For Aesthetic & General Dermatology, L L C

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