The Effects of Vitamin D and Selenium Supplementation, Alone and in Combination, on Glycemic Indices, Inflammatory Markers, Adipokines, and Metabolic Parameters in Patients with Type 2 Diabetes

Start Date19 Jan 2025

Sponsor / Collaborator

Kermanshah University of Medical Sciences

IRCT20241121063793N1

/ SuspendedPhase 3IIT

A comparative study of the effect of trazodone, melatonin and trazodone/melatonine in the treatment of sleep disorders following traumatic brain injury

Start Date19 Jan 2025

Sponsor / Collaborator

Kermanshah University of Medical Sciences

100 Clinical Results associated with Kermanshah University of Medical Sciences

0 Patents (Medical) associated with Kermanshah University of Medical Sciences

12,705

Literatures (Medical) associated with Kermanshah University of Medical Sciences

01 Dec 2025·Molecular Biology Reports

Green synthesis of silver nanoparticles using Acroptilon repens aqueous extract and their antibacterial efficacy against multidrug-resistant Acinetobacter baumannii

Article

Author: Shamsoddini, Seyed Mahdi ; Shahbazi, Shahla ; Karizi, Shohreh Zare ; Davoudi, Mahdieh

BACKGROUNDAcinetobacter baumannii is a critical pathogen associated with hospital-acquired infections, particularly in burn and intensive care unit (ICU) patients, and is notorious for its high level of antibiotic resistance. This study aims to evaluate the antibacterial potential of silver nanoparticles (AgNPs) synthesized using Acroptilon repens extract as a promising alternative treatment for combating multidrug-resistant A. baumannii.METHODS AND RESULTSTwelve clinical isolates of A. baumannii were identified through biochemical testing. Antibiotic susceptibility testing using the Kirby-Bauer disk diffusion method revealed universal resistance to ceftazidime, amikacin, imipenem, gentamicin, ciprofloxacin, and piperacillin-tazobactam, while all isolates remained sensitive to colistin (p ≤ 0.05). AgNPs were synthesized using A. repens extract and characterized through transmission electron microscopy (TEM), scanning electron microscopy (SEM), particle size analysis (PSA), UV-Vis spectroscopy, X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FT-IR). TEM analysis showed that the AgNPs had a spherical morphology with an average particle size of approximately 30 nm, while SEM confirmed their spherical shape and size distribution, ranging from 10 to 130 nm, with a mean size of 38.89 nm. UV-Vis spectroscopy confirmed the successful formation of AgNPs, indicated by a distinct broad absorption peak between 400 and 480 nm. XRD analysis validated the crystalline nature of the nanoparticles, with characteristic peaks at 2θ values of 38.21°, 46.28°, 64.57°, and 77.49°, corresponding to the (111), (200), (220), and (311) planes of face-centered cubic (fcc) silver. Antibacterial activity was evaluated by determining the minimum inhibitory concentration (MIC), which ranged from 50 to 400 µg/mL. The highest inhibitory activity was observed at 400 µg/mL. Gene expression analysis using quantitative real-time PCR (qRT-PCR) demonstrated downregulation of the oprD and carO porin genes following AgNP treatment. However, these reductions were not statistically significant (p = 0.302 and p = 0.198, respectively).CONCLUSIONSAgNPs synthesized from A. repens demonstrated strong antibacterial activity against multidrug-resistant A. baumannii. While downregulation of porin genes was observed, further investigation is required to elucidate the underlying mechanisms of action and assess their potential clinical applications. These findings support the potential of AgNPs as an alternative therapeutic strategy for addressing A. baumannii infections resistant to conventional antibiotics.

01 Aug 2025·Nano LIFE

Carboxy Methyl Cellulose-based Gel Containing Nanoliposomes Loaded with Chilli Pepper and Ginger Extracts as a Novel Topical Anti-obesity Formulation

Author: Aghaz, Faranak ; Jallilian, Saba ; Arkan, Elham ; Zarneshan, Seyede Nazanin ; Alvandi, Hosna

Introduction: An important worldwide health concern that has an adverse effect on both people and societies is obesity. It may result in diseases linked to obesity, a lower standard of living, or even death. Therefore, there is a pressing need for more advanced and novel drug delivery techniques, such as topical therapy, to treat obesity. However, there are several obstacles to overcome, including low molecular weight, high lipophilicity, limited efficacy, and skin irritation. It seems that nanoliposomes (NLPs) are a nearly ideal drug-carrier system. They are thought to be the best delivery vehicles for physiologically active substances, both in vitro and in vivo, due to their advantages in biology and technology. Material and Method: Carboxy methyl cellulose-based gel containing NLPs loaded with chilli pepper and ginger extracts (CMC-gel containing Chi/G-NLPs) has been studied. The NLPs containing the extracts are synthesized using a thin layer hydration and ultrasound method. Then nanocarrier’s physicochemical properties, drug loading capacity, and rate of release are evaluated. Results: Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), Zeta potential (ZP), in vitro release profile, and in vitro skin absorption assays verify the optimal physicochemical characteristics, 30% in vitro skin absorption and slow control in vitro release behavior. Conclusion: When considered collectively, our findings supported the idea that using Chi/G-NLPs in a CMC-gel will optimize its effectiveness as an innovative topical therapy for obesity.

01 Apr 2025·Tissue and Cell

Exosomes and tissue engineering: A novel therapeutic strategy for nerve regenerative

Review

Author: Nochalabadi, Azadeh ; Khazaei, Mozafar ; Rezakhani, Leila

Damage to nerves negatively impacts quality of life and causes considerable morbidity. Self-regeneration is a special characteristic of the nervous system, yet how successful regeneration is accomplished remains unclear. Research on nerve regeneration is advancing and accelerating successful nerve recovery with potential new approaches. Eukaryote cells release extracellular vesicles (EVs), which control intercellular communication in both health and disease. More and more, EVs such as microvesicles and exosomes (EXOs) are being recognized as viable options for cell-free therapies that address complex tissue regeneration. The present study highlights the functional relevance of EVs in regenerative medicine for nerve-related regeneration. A subclass of EVs, EXOs were first identified as a way for cells to expel undesirable cell products. These nanovesicles have a diameter of 30-150 nm and are secreted by a variety of cells in conditions of both health and illness. Their benefits include the ability to promote endothelial cell growth, inhibit inflammation, encourage cell proliferation, and regulate cell differentiation. They are also known to transport functional proteins, metabolites, and nucleic acids to recipient cells, thus playing a significant role in cellular communication. EXOs impact an extensive array of physiological functions, including immunological responses, tissue regeneration, stem cell conservation, communication within the central nervous system, and pathological processes involving cardiovascular disorders, neurodegeneration, cancer, and inflammation. Their biocompatibility and bi-layered lipid structure (which shields the genetic consignment from deterioration and reduces immunogenicity) make them appealing as therapeutic vectors. They can pass through the blood brain barrier and other major biological membranes because of their small size and membrane composition. The creation of modified EXOs is a dynamic area of research that supports the evaluation of diverse therapeutic freights, improvement of target selectivity, and manufacturing optimization.

100 Deals associated with Kermanshah University of Medical Sciences

100 Translational Medicine associated with Kermanshah University of Medical Sciences

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