Delving into the Latest Updates on Kermanshah University of Medical Sciences with Synapse

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Nervous System Diseases

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Abstract:Mayonnaise is one of the most popular seasonings and well-established sauces globally, which is considered a high-fat and high-calorie product due to its high oil content. However, excessive consumption of fat (especially saturated fatty acids) leads to an increased risk of various chronic diseases including cardiovascular disease, coronary artery disease, type 2 diabetes, Covid-19, and obesity. Therefore, the demand for low-fat, low-calorie food products is increasing. Fat replacers (FR) have recently been employed to decrease fat content while ensuring consumer acceptability. Production of low-fat mayonnaise without significant quality changes is challenging from an industrial point of view. In this review, the fat replacement approach in the low/or reduced-fat mayonnaise and salad dressing systems is conferred in various aspects, including functional, technological, and sensorial properties. The type and source of used FRs, their benefits and drawbacks, and their nutritional effects are also discussed. Due to the unique functional role of fat, the development of low-fat dressing products that meet consumer demands is more complex than those provided by FRs. Also, although fat and calories are effectively reduced, due to the lack of human intervention studies, future research should focus on the safety of these fat substitutes.

01 Jan 2025·Journal of Molecular Structure

Mechanistic investigation of the cytotoxicity of new Ce(IV) and Zn(II) complexes containing pyridinedicarboxylic acid derivatives against the SW480 cell line

Author: Aliabadi, Alireza ; Abdolmaleki, Sara ; Khaksar, Samad

Two cerium(IV) (C1) and zinc(II) (C2) complexes formulated as (aeea)₂[Ce(pydc)₃].5H₂O (where pydc is pyridine-2,6-dicarboxylate and aeea is aminoethylethanolamine) and [Zn(hpydc)(dmp)].2H₂O (where hpydc is 4-hydroxy-pyridine-2,6-dicarboxylate and dmp is 2,9-dimethyl-1,10-phenanthroline) were obtained by a one-pot reaction of organic ligands and the metal salts Ce(NO₃)₂.6H₂O and Zn(NO₃)₂.6H₂O.The complexes were characterized by spectroscopic methods and single-crystal X-ray diffraction.The MTT assay was performed for the compounds against four cell lines, including human hepatocellular carcinoma (BEL-7404), primary human colon cancer (SW480), metastatic human colon cancer (SW620) and normal human colon tissue (CCD841CoN), which showed the highest sensitivity to C1 (IC₅₀= 1.89 μM, MAE= 72.46%) (where MAE represents the maximal antiproliferative effect).C1 demonstrated its ability as a redox-active compound to generate high levels of reactive oxygen species (ROS) in this cell line.Mechanistic investigation of the efficacy of the compounds on SW480 cells showed that C1 can induce bimodal cell death by both (intrinsic and extrinsic) apoptosis and autophagy, whereas only the intrinsic apoptosis pathway was detected when the aforementioned cells were treated with C2.SW480 cells treated with C1 showed remarkable morphol. changes as well as a reduction in tumor size in the SW480 3D spheroid model.

01 Jan 2025·Current Nutrition & Food Science

Prevalence and Pattern of Dietary Supplement Use in Bodybuilding Athletes

Author: Abdollahzad, Hadi ; Daryoushi, Hooman ; Soroush, Ali ; Naghibifar, Zahra ; Kordloo, Yashar ; Baharirad, Nadya ; Nouri, Roghayeh ; Naghipour, Armin

Introduction:Using sports supplements is a common strategy for improving athletic performance. The prevalence of using sports supplements among adolescent and young athletes has been increasing in recent years.Methods:This descriptive-analytical study was performed on 200 bodybuilding athletes. The data collection tool was a pre-made questionnaire. The questionnaire was distributed among the athletes by available methods and collected after filling out. The chi-square test, Fisher's exact test, and logistic regression model were used to analyze the data.Results:The prevalence of using sports supplements was 62.5% (n=125), with males accounting for 67.5% (n=135) of the consumers. Various forms of proteins (43.5%, n=87), vitamins (40.5%, n=81), and hormones (38.5%, n=77) were the most commonly recommended supplements by the coaches (58.4%, n=73) and other athletes (31.2%, n=9). The sports supplements have been considered to have no side effects by 16.8% (n=21) of the athletes; however, 19.2% (n=24) mentioned cardiac adverse events, and 13.6% (n=17) pointed to renal complications as potential consequences of supplement use. The results of statistical tests and a logistic regression model showed a statistically significant relationship between sex, age, education and income, and sports supplement use (p=0.001).Conclusion:According to the results of this current study, a significant proportion of bodybuilding athletes take sports supplements without being aware of the side effects. Therefore, it is necessary to develop an educational program to inform the population about the mechanism of action of supplements in the body and also educate athletes and coaches about the correct use, side effects, and irreversible consequences of improper supplements use.

100 Deals associated with Kermanshah University of Medical Sciences

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100 Translational Medicine associated with Kermanshah University of Medical Sciences

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Pipeline

Pipeline Snapshot as of 24 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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