Beijing Kangchuanglian Biopharmaceutical Technology Research

Indagamol Inhalation Powder (II) (Specification: 150 μg /50 μg/160 μg) developed by Beijing Kangchuanglian Biopharmaceutical Technology Research Co., Ltd. was used as the test preparation. According to the relevant provisions of the bioequivalence test, Indagamol Inhalation Powder (II) (Specification: 150 μg /50 μg/160 μg; Trade Name: Enerzair®) certified by Novartis Pharma AG was used as the reference preparation. The absorption rate and degree of absorption in healthy humans were compared to investigate the bioequivalence of the two preparations in humans. Secondary objective: To observe the safety of the test preparation Indagamol Inhalation Powder (II) and the reference preparation Indagamol Inhalation Powder (II) (Enerzair®) in healthy subjects.

Main purpose: Indacaterol mometasone inhalation powder (III) (specification: 150 μg / 320 μg) developed by Beijing Kangchuanglian Biopharmaceutical Technology Research Co., Ltd. was used as the test preparation. According to the relevant provisions of the bioequivalence test, indacaterol mometasone inhalation powder (III) (specification: 150 μg / 320 μg; trade name: Atectura® Breezhaler®) certified by Novartis Pharma AG was used as the reference preparation. The absorption rate and degree of absorption in healthy humans were compared to investigate the bioequivalence of the two preparations in humans. Secondary purpose: To observe the safety of the test preparation indacaterol mometasone inhalation powder (III) and the reference preparation indacaterol mometasone inhalation powder (III) (Atectura® Breezhaler®) in healthy subjects.

Primary objective: In patients with type 2 diabetes treated with metformin hydrochloride, to demonstrate the similarity of the efficacy of semaglutide injection (HD1916) and Novota® in reducing HbA1c at week 32 after treatment. Secondary objective: In patients with type 2 diabetes treated with metformin hydrochloride, to compare the similarity, safety, immunogenicity, and PK characteristics of semaglutide injection (HD1916) and Novota® in other efficacy endpoints after treatment.