Delving into the Latest Updates on Neurotec Pharma SL with Synapse

Overview

Tags

Nervous System Diseases

Immune System Diseases

Endocrinology and Metabolic Disease

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	1
Immune System Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

KATP channels	1

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS) that causes significant disability. Immunosuppressive and immunomodulatory drugs have been designed for years to treat MS, as it was considered the most appropriate way to balance the effects of the patients' immune reaction. However, basic and clinical research has recently offered new data that help to better understand the nature of this complex disease, allowing changing the treatment approach. As a consequence, the first disease-modifying drug with a suggested neuroprotective and antioxidative mechanism of action has been recently approved, broadening and improving the therapeutic landscape to fight against MS. In this review, we focused our attention on promising neuroprotective or neuroregenerative drugs that are currently approved or in clinical trials. These neuroprotective therapies provide new valid alternatives that significantly could impact on disease progression and neurodegenerative changes in MS.

01 May 2012·Amyotrophic Lateral Sclerosis

Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis

Article

Author: Mancera, Pilar ; Osta, Rosario ; Manzano, Raquel ; Oliván, Sara ; Casas, Caty ; Navarro, Xavier ; Mancuso, Renzo ; Pastén-Zamorano, Andrea

Knowledge of the potential effect of genetic background in disease models is important. The SOD1-G93A transgenic mouse is the most widely used model in amyotrophic lateral sclerosis (ALS). Since these animals show considerable variability both in the onset and the progression of the disease, this study aimed to characterize the potential differences between the two most widely used strains, C56BL/6 (B6) and B6SJL. A rotarod test was carried out to assess strength and motor coordination, while electrophysiology tests were performed to evaluate the function of upper and lower motor neurons. Survival of the animals and motor neuron loss were also studied. The results did not show any background effect regarding the rotarod test, despite the differences in the pattern of decline in central and peripheral motor conduction. The onset of motor neuron abnormalities was later in B6SJL mice, but progressed more rapidly. Lifespan was longer for B6 than for B6SJL animals. In conclusion, background differences in disease onset and progression are important. The characteristics of the strain should be taken into account in experimental design of therapeutic studies.

NutrientsQ2 · MEDICINE

Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice

Q2 · MEDICINE

ArticleOA

Author: Cordobilla, Begoña ; Wappenhans, Blanca ; Rueda, Fèlix ; Pugliese, Marco ; Mancera, Pilar ; Virgili, Noemí ; Domingo, Joan C ; Espinosa-Parrilla, Juan F

Many neurodegenerative diseases are associated, at least in part, to an inflammatory process in which microglia plays a major role. The effect of the triglyceride form of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (TG-DHA) was assayed in vitro and in vivo to assess the protective and anti-inflammatory activity of this compound. In the in vitro study, BV-2 microglia cells were previously treated with TG-DHA and then activated with Lipopolysaccharide (LPS) and Interferon-gamma (IFN-γ). TG-DHA treatment protected BV-2 microglia cells from oxidative stress toxicity attenuating NO production and suppressing the induction of inflammatory cytokines. When compared with DHA in the ethyl-ester form, a significant difference in the ability to inhibit NO production in favor of TG-DHA was observed. TG-DHA inhibited significantly splenocyte proliferation but isolated CD4+ lymphocyte proliferation was unaffected. In a mice model of autoimmune encephalomyelitis (EAE), 250 mg/kg/day oral TG-DHA treatment was associated with a significant amelioration of the course and severity of the disease as compared to untreated animals. TG-DHA-treated EAE mice showed a better weight profile, which is a symptom related to a better course of encephalomyelitis. TG-DHA may be a promising therapeutic agent in neuroinflammatory processes and merit to be more extensively studied in human neurodegenerative disorders.

100 Deals associated with Neurotec Pharma SL

Login to view more data

100 Translational Medicine associated with Neurotec Pharma SL

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 20 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 2 Clinical

1

5

Other

Login to view more data

Current Projects

Drug(Targets)	Indications	Global Highest Phase

Diazoxide ( KATP channels )	Multiple Sclerosis More	Phase 2
NT-KO-009	Neuritis More	Discontinued
NT-CC-017	Neurodegenerative Diseases More	Discontinued
NT-KO-012	Neuritis More	Discontinued
NT-FV-007	Motor Neuron Disease More	Discontinued