Delving into the Latest Updates on Changchun Heber Biological Technology Co. Ltd. with Synapse

Overview

Tags

Infectious Diseases

Otorhinolaryngologic Diseases

Nervous System Diseases

Conjugated vaccine

Prophylactic vaccine

Interferons

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	2
Neoplasms	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Biosimilar	1
Conjugated vaccine	1
Prophylactic vaccine	1
Interferons	1

Top 5 Target	Count

IFNAR(Interferon alpha/beta receptor)	1

The enhancement of stress resistance is crucial for delaying aging and extending a healthy lifespan. Traditional Chinese medicine (TCM), a cherished treasure of Chinese heritage, has shown potential in mitigating stress and promoting longevity. This study integrates network pharmacology and in vivo analysis to investigate the mechanisms and effects of Curcumae Rhizoma (C. Rhizoma), known as “E Zhu” in Chinese. Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC-MS/MS) identified 10 active compounds in its aqueous extract, interacting with 128 stress-related targets. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed pathways such as stress response, FoxO signaling, and insulin resistance. In Caenorhabditis elegans, 10 mg/mL of C. Rhizoma aqueous extract improved resistance to UV, thermal, oxidative, and pathogen-induced stress, extending lifespan in a dose-dependent manner. Mechanistically, it reduced reactive oxygen species (ROS), increased superoxide dismutase (SOD) activity, and enhanced UV resistance via the insulin/IGF-1 pathway and DAF-16 translocation. Molecular docking highlighted hexahydrocurcumin (HHC) and related compounds as key bioactives. Furthermore, we also observed that C. Rhizoma aqueous extract significantly extended both the lifespan and healthspan of nematodes. These findings highlight the potential of C. Rhizoma in stress mitigation and longevity promotion, offering valuable insights into the therapeutic applications of TCM.

Zhongguo Weisheng Gongchengxue

Extraction process of Danqihuoxue Granules

Author: Tang, Bo-yu ; Tian, Xiao-lin ; Wang, Pei ; Wang, Dan

Objective: To optimize the extraction process of Danqihuoxue Granules.Method: The parameters were optimized by an orthogonal method L₉ (3⁴) using flavonoid content as an index.The results showed that ethanol concentration was the principal factor and others were minor factors.The optimum process was 70% ethanol at 8 folds and extraction for 2 h twice.Conclusion: Within the range of selected factors, ethanol took the first place in extractionThe process was stable and feasible.

Zhongguo Shengwu Zhipinxue Zazhi

Application of constrained four-parameter Logistic regression in biological activity assay of interferon

Author: Jiang Li-jun ; Chen Wan-ge ; Xu Fu-ping ; Li Jian-ping

Objective To improve the method for data processing in the current biol. activity assay of interferon(IFN).Methods The parameters in four-parameter Logistic regression was constrained to make the curve"slope-proportioned"or paralleled.Results The exptl. data were analyzed by the improved method,and the results obtained were similar to those obtained by the method currently used.The improved method may be used for primary estimation of reliability of the assay as well as the confidential intervals of test results.Conclusion Constrained four-parameter Logistic regression may be used for the biol. activity assay of IFN,of which the model was more intact and reliable for statistical anal. than the current method for data processing.

100 Deals associated with Changchun Heber Biological Technology Co. Ltd.

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100 Translational Medicine associated with Changchun Heber Biological Technology Co. Ltd.

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Pipeline

Pipeline Snapshot as of 11 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 3 Clinical

1

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Interferon alfa-2b(Changchun Heber Biological Technology Co Ltd) ( IFNAR )	Neoplasms More	Approved
Synthetic Haemophilus Influenzae Type b Conjugate Vaccine ( Changchun Heber Biological Technology)	Meningitis More	Phase 3