[Translation] A multicenter, randomized, double-blind, placebo-controlled phase Ib clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of Duanjin Detoxification Capsule in patients recovering from opioid addiction

主要目的：评价断金戒毒胶囊在阿片类物质成瘾康复期患者中的安全性、耐受性。次要目的：评价断金戒毒胶囊在阿片类物质成瘾康复期患者中的药代动力学（PK）特征；初步评价断金戒毒胶囊在阿片类物质成瘾康复期患者中防复吸的有效性。

[Translation]

Primary objective: To evaluate the safety and tolerability of Duanjin Detoxification Capsules in patients recovering from opioid addiction. Secondary objective: To evaluate the pharmacokinetic (PK) characteristics of Duanjin Detoxification Capsules in patients recovering from opioid addiction; to preliminarily evaluate the effectiveness of Duanjin Detoxification Capsules in preventing relapse in patients recovering from opioid addiction.

Start Date26 Sep 2022

Sponsor / Collaborator

Yunnan Mingjing Henry Pharmaceutical Co Ltd.

[+1]

CTR20212791

/ CompletedPhase 1

评价食物对断金戒毒胶囊药代动力学特征和安全性影响的单中心、随机、开放、单剂量、两周期、交叉的Ⅰ期临床研究

[Translation] A single-center, randomized, open-label, single-dose, two-period, crossover phase I clinical study to evaluate the effect of food on the pharmacokinetic characteristics and safety of Duanjin Jiedu Capsule

主要目的：评价食物对断金戒毒胶囊药代动力学特征的影响。次要目的：评价断金戒毒胶囊在健康受试者体内的安全性。

[Translation]

Primary objective: To evaluate the effect of food on the pharmacokinetic characteristics of Duanjin Detoxification Capsules. Secondary objective: To evaluate the safety of Duanjin Detoxification Capsules in healthy subjects.

Start Date10 Nov 2021

Sponsor / Collaborator

Yunnan Mingjing Henry Pharmaceutical Co Ltd.

[+1]

CTR20191146

/ CompletedPhase 1

断金戒毒胶囊在中国健康受试者中的随机、双盲、安慰剂对照剂量递增安全性、耐受性及药代动力学试验

[Translation] A randomized, double-blind, placebo-controlled, dose-escalation safety, tolerability, and pharmacokinetics trial of Duanjin Detoxification Capsule in healthy Chinese subjects

评价健康中国受试者单、多剂量递增条件下服用断金戒毒胶囊后的安全性、耐受性情况，在血药浓度普遍高于最低检测限前提下，初步探索断金戒毒胶囊在人体内药代动力学特征，为后续临床试验提供参考依据。

[Translation]

To evaluate the safety and tolerability of Duanjin Drug Relief Capsules in healthy Chinese subjects after taking them under single and multiple escalating doses. Under the premise that the blood drug concentration is generally higher than the minimum detection limit, the pharmacokinetic characteristics of Duanjin Drug Relief Capsules in humans are preliminarily explored to provide a reference for subsequent clinical trials.

Start Date28 Aug 2019

Sponsor / Collaborator

Yunnan Mingjing Henry Pharmaceutical Co Ltd.

[+1]

100 Clinical Results associated with Institute of Basic Medical Sciences Academy of Military Medical Sciences of PLA

0 Patents (Medical) associated with Institute of Basic Medical Sciences Academy of Military Medical Sciences of PLA

8,256

Literatures (Medical) associated with Institute of Basic Medical Sciences Academy of Military Medical Sciences of PLA

01 Jan 2025·Operative Neurosurgery

Omentomyelopexy for the Treatment of a Persistent Lumbar Pseudomeningocele: A Case Report With Technical Note

Article

Author: Stanković, Svetozar ; Stanković, Jadranka ; Pavlićević, Goran ; Minić, Ljubodrag ; Lepić, Milan ; Djurdjević, Alekandar

BACKGROUND AND IMPORTANCE:Pseudomeningoceles are extradural accumulations of cerebrospinal fluid. In most cases, they appear as a complication of spinal operations. Omentomyelopexy is a surgery in which an autologous omentum flap is implanted over the dural opening. We describe a case of persistent pseudomeningocele treated with omentomyelopexy.CLINICAL PRESENTATION:A 37-year-old man sustained a T12-L1 AO B3 fracture during a motorcycle accident. He underwent posterolateral fusion and then neurological rehabilitation. Two years later, however, his condition worsened, and he experienced progressive weakness—he was diagnosed with an intramedullary cyst, which was treated with laminectomy, arachnolysis and cystotomy. A pseudomeningocele developed afterward, and the patient underwent multiple reoperations in the following years, none of which were effective. Omentomyelopexy, a complex procedure aimed to facilitate cerebrospinal fluid absorption and subsequent formation of a permanent membrane, was offered to the patient as a “last resort.” After undergoing omentomyelopexy, his pseudomeningocele resolved.CONCLUSION:Although it should be reserved for exceptionally pertinent cases, omentomyelopexy is a viable option for managing persistent pseudomeningocele. However, further research is needed to better understand the effects and benefits of omentomyelopexy in this context.

01 Dec 2024·Applied Biochemistry and Microbiology

Expression, Purification and Partial Characterization of Recombinant S-Adenosyl-L-Homocysteine Hydrolase from Banana

Author: Djurasinovic, T. ; Gavrovic-Jankulovic, M. ; Mahfoud, A. ; Bazovic, V. ; Trbojevic-Ivic, J. ; Ramdan, A. ; Nesic, A. ; Bazović, V. ; Gavrović-Jankulović, M. ; Trbojević-Ivić, J. ; Đurašinović, T. ; Nešić, A.

Abstract: We have recently identified S-adenosyl-L-homocysteine hydrolase (SAHH) as a novel banana allergen with a potentially decisive role in the development of cross-reactivity between plant-derived food and respiratory allergens.The recalcitrant nature of banana pulp and intrinsically low abundance of SAHH limit its production from natural sources.Our objective was to optimize production and biochem. characterize recombinant banana SAHH (rSAHH) with implications for the food safety industry, food allergy diagnosis and treatment, and basic research in mol. allergol. rSAHH with C-terminal 6His tag was successfully expressed in Escherichia coli BL21(DE3) cells, and purified to homogeneity by immobilized metal affinity chromatog. (IMAC), yielding 10 mg of rSAHH/L of cell culture under optimized conditions.It is functional as a monomer with an approx. mol. weight of 55 kDa and pI of 5.83.Structural integrity, IgE reactivity, and biol. activity of rSAHH were confirmed by Western blot and standard colorimetric SAHH assay with Ellman′s reagent, resp.As a mesophilic enzyme with wide pH stability and high 8-mo storage stability, rSAHH obtained in this study is the promising candidate for further diagnostic and therapeutic applications.To the author′s best knowledge, rSAHH is the only recombinantly produced plant-derived SAHH thus far.

01 Sep 2024·Egyptian Journal of Dermatology and Venereology

Role of serum cd4+, cd25+, and foxp3+ cells’ segmental and nonsegmental vitiligo

Author: Mohammed, Shereen R. ; Raheem, Talal A.A. ; Farouk, Ahmed M. ; Gamal, Ahmed S. ; Mohammed, Mohammed H.

BackgroundVitiligo is an autoimmune skin disease presented with depigmented macules and patches. Vitiligo has an impact on the quality of life. The etiopathogenesis of vitiligo is multifactorial, including genetic, immune dysregulation, and oxidative stress mechanisms. Lately, several researches have underlined the pivotal function of regulatory T cells (Tregs) in the vitiligo pathogenesis with lack of data regarding their role in segmental vitiligo (SV).ObjectiveTo investigate the role of Tregs in SV and nonsegmental vitiligo (NSV) pathogenesis and its correlation with disease activity and severity.Patients and methodsThis case–control study included 20 cases with NSV and 10 cases with SV in addition to 10 healthy volunteers. Vitiligo Area Scoring Index and Vitiligo Disease Activity scores were estimated for vitiligo cases and all the included participants were assessed for the percentage of serum CD4+, CD25+, and FOXP3+ T cells using flow cytometry staining buffer.ResultsThere was significant reduction of the peripheral Tregs in NSV cases in comparison with healthy participants and negative correlation with their percentage to disease activity. On the other hand, there was insignificant difference between the percentage of peripheral Tregs in SV cases and healthy participants. Also, there was insignificant correlation between peripheral Tregs and both severity and activity of the disease among SV cases.ConclusionNSV cases showed significant reduction of the peripheral Tregs and negative correlation with disease activity, indicating the importance of Tregs in the etiopathogenesis of NSV and hence future targeting therapy. On the other hand, in SV cases, there was insignificant reduction of peripheral Tregs and insignificant correlation between their percentage and both severity and activity indicating mosaic etiopathogenesis.

100 Deals associated with Institute of Basic Medical Sciences Academy of Military Medical Sciences of PLA

100 Translational Medicine associated with Institute of Basic Medical Sciences Academy of Military Medical Sciences of PLA

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 08 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

Other

Current Projects

Drug(Targets)	Indications	Global Highest Phase

Jiejin Jiedu Capsule	Opium Dependence More	Phase 1
NSC-631570 ( Tubulin )	Influenza, Human More	Pending
MIL-77 ( Envelope (E) protein )	Hemorrhagic Fever, Ebola More	Pending

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis