Last update 01 Nov 2024

Chongqing Armed Police Hospital

Hospital|

Beijing Shi, China

Hospital|

Beijing Shi, China

Last update 01 Nov 2024

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Translational Medicine

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Clinical Trials associated with Chongqing Armed Police Hospital

ChiCTR2400088532 / SuspendedPhase 4IIT

A prospective study on the effect of Sacubitril Valsartan in treatment of type 2 diabetes mellitus complicated with hypertension on insulin resistance

Start Date20 Aug 2024

Sponsor / Collaborator

Chongqing Armed Police Hospital

ChiCTR2400086917 / SuspendedEarly Phase 1IIT

A System for Localizing Epileptogenic Focus in Patients with Cortical Developmental Malformations Based on Artificial Intelligence and Machine Learning

Start Date15 Jul 2024

Sponsor / Collaborator

Chongqing Armed Police Hospital

ChiCTR1800016902 / SuspendedPhase 4IIT

A randomized controlled study of metformin combined with insulin add different mechanismsoral hypoglycenmic drugs in type 2 diabetes

Start Date01 Sep 2018

Sponsor / Collaborator

Chongqing Armed Police Hospital

100 Clinical Results associated with Chongqing Armed Police Hospital

0 Patents (Medical) associated with Chongqing Armed Police Hospital

Literatures (Medical) associated with Chongqing Armed Police Hospital

01 Sep 2024·Histology and histopathology

Altered expression of the Plexin-B2 system in tuberous sclerosis complex and focal cortical dysplasia IIb lesions.

Article

Author: Shen, Kai-Feng ; Zhang, Chun-Qing ; Zhang, Li ; Xu, Sen-Lin ; Wang, Zhong-Ke ; Liu, Shi-Yong ; Yang, Xiao-Lin ; Yang, Hui ; Zhu, Gang ; Dai, Lu ; Huang, Jun ; Liao, Xiang ; Li, Xing-Yi

Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) type IIb are the predominant causes of drug-refractory epilepsy in children. Dysmorphic neurons (DNs), giant cells (GCs), and balloon cells (BCs) are the most typical pathogenic profiles in cortical lesions of TSC and FCD IIb patients. However, mechanisms underlying the pathological processes of TSC and FCD IIb remain obscure. The Plexin-B2-Sema4C signalling pathway plays critical roles in neuronal morphogenesis and corticogenesis during the development of the central nervous system. However, the role of the Plexin-B2 system in the pathogenic process of TSC and FCD IIb has not been identified. In the present study, we investigated the expression and cell distribution characteristics of Plexin-B2 and Sema4C in TSC and FCD IIb lesions with molecular technologies. Our results showed that the mRNA and protein levels of Plexin-B2 expression were significantly increased both in TSC and FCD IIb lesions versus that in the control cortex. Notably, Plexin-B2 was also predominantly observed in GCs in TSC epileptic lesions and BCs in FCD IIb lesions. In contrast, the expression of Sema4C, the ligand of Plexin-B2, was significantly decreased in DNs, GCs, and BCs in TSC and FCD IIb epileptic lesions. Additionally, Plexin-B2 and Sema4C were expressed in astrocytes and microglia cells in TSC and FCD IIb lesions. Furthermore, the expression of Plexin-B2 was positively correlated with seizure frequency in TSC and FCD IIb patients. In conclusion, our results showed the Plexin-B2-Sema4C system was abnormally expressed in cortical lesions of TSC and FCD IIb patients, signifying that the Plexin-B2-Sema4C system may play a role in the pathogenic development of TSC and FCD IIb.

01 Nov 2023·Chinese Journal of Traumatology

A foot structure study of new arch flexibility grading system based on three-dimensional arch volume

Article

Author: Tao, Lun ; Xiang, Hong-Yi ; Deng, Miao ; Liu, Xiang-Dong ; Xiong, Yan ; Liu, Jun ; Wang, Wei

PURPOSEDifferent arch structures may cause different foot function injuries. In the past, the arch structure and flexibility of the foot were often defined by the height of the arch, and there was no three-dimensional (3D) structure classification method. In order to form a more complete 3D description, we propose a new classification system of arch volume flexibility (AVF), and then use this new classification system to investigate the relationship between the AVF and arch index (AI), and the arch height flexibility (AHF) and AI, respectively.METHODSIt is proposed to recruit 180 young male adults for the test. We obtained arch volume and AI through 3D scanning and obtained the navicular height through manual measurement. Based on these data, we calculated the AHF and the AVF. Using the quintile method, these arches are divided into very stiff, stiff, neutral, flexible, and very flexible. According to AI value, all arches were divided into cavus, rectus, and planus. The distribution of AVF was compared using χ² goodness of fit test. The spearman correlation test was used to compare the AHF and AVF. A p < 0.05 indicates that the difference is statistically significant.RESULTSAll participants' plantar data was obtained through 3D scanning, but only 159 of them were complete, so only 318 feet had valid data. The left AHF is (21.23 ± 12.91) mm/kN, and the right AHF is (21.71 ± 12.69) mm/kN. The AVF of the left foot arch is (207.35 ± 118.28) mm³/kg, while the right one is (203.00 ± 117.92) mm³/kg, and the total AVF of the arch was (205.17 ± 117.94) mm³/kg. There was no statistical difference in the AVF between the left and right feet for the same participant (n = 159, p = 0.654). In cavus, the percentage of arch with AVF is 21.4% (very stiff), 21.4% (stiff), 14.3% (neutral), 7.1% (flexible), and 35.7% (very flexible). In rectus, the percentage of arch with AVF is 23.9% (very stiff), 19.6% (stiff), 14.7% (neutral), 24.5% (flexible), and 17.2% (very flexible). In planus, the percentage of arch with AVF is 14.9% (very stiff), 20.6% (stiff), 27.0% (neutral), 16.3% (flexible), and 21.3% (very flexible). Moreover, the correlation between AHF and AVF is not significant (p = 0.060).CONCLUSIONIn cavus, rectus, and planus, different AVF accounts different percentage, but the difference is not statistically significant. AVF is evenly distributed in the arches of the feet at different heights. We further found the relationship between AHF and AVF is not significant. As a 3D index, AVF may be able to describe the flexibility of the arch more comprehensively than AHF.

25 May 2023·Acta Neurologica Scandinavica

Association of Lateralized Interictal Epileptiform Discharges with Postsurgical Seizure Outcomes in Patients with Tuberous Sclerosis Complex: A 10-Year Retrospective Study at a Single Center

Author: He, Zeng ; Wang, Wei ; Lv, Shengqing ; Yang, Hui ; Zhang, Jingyi ; Li, Shujing ; Liu, Zhonghong ; Liu, Lihong ; Xiang, Shu ; Huang, Kaixuan ; Zhang, Chunqing ; Shi, Xianjun ; Wang, Shufang ; Wang, Miao ; Yang, Xiaolin ; Li, Yang ; Wang, Zhongke ; Liu, Shiyong

Objective. Tuberous sclerosis complex (TSC) is a rare neurodevelopmental disorder often associated with intractable epilepsy, and surgical resection is the effective therapeutic approach to alleviate seizures in TSC patients. Scalp electroencephalogram (EEG) is a noninvasive method used to diagnose epilepsy; however, the relationship between scalp video-EEG findings and postsurgical seizure outcomes has not been fully evaluated in TSC patients. Materials and Methods. The relationship between clinical characteristics and seizure outcomes of TSC patients with 1-year, 5-year, and 10-year follow-ups was retrospectively analyzed. We explored the association of interictal epileptiform discharges (IEDs) with postsurgical seizure outcomes. Further, the differences in clinical characteristics among four IED patterns (focal, lateralized, multifocal, and generalized IEDs) were assessed. Results. A total of 82 patients were enrolled in this study. There were 82 patients with 1-year follow-up, 75 patients with 5-year follow-up, and 57 patients with 10-year follow-up, and the IEDs were associated with the postsurgical outcomes. Patients with focal, lateralized, and generalized IEDs had seizure freedom (SF) in 1-year follow-up, respectively. Intriguingly, patients with lateralized IEDs had long-term SF in 5-year and 10-year follow-ups. Conclusions. A significant association existed between IEDs and long-term postsurgical outcomes in TSC patients. TSC patients with lateralized IEDs often showed long-term SF and mild clinical epileptic characteristics. According to our study, IEDs may guide clinical care for TSC patients with intractable epilepsy.

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100 Translational Medicine associated with Chongqing Armed Police Hospital

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