Delving into the Latest Updates on Yangtze University with Synapse

Overview

Tags

Neoplasms

Immune System Diseases

Digestive System Disorders

Small molecule drug

CAR-T

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Hemic and Lymphatic Diseases	1
Immune System Diseases	1

Top 5 Drug Type	Count

CAR-T	1
Small molecule drug	1

Top 5 Target	Count

IL-6 x STAT3	1
BCMA x CD38	1

This study addresses the problem of low-accuracy production forecasting for horizontal shale gas wells by applying a random forest algorithm and considering both the phys. reservoir parameters and the engineering fracturing parameters.Based on the interpretation of logging data, drilling data, fracturing data, and sectional production data from the Fuling shale gas field, the random forest algorithm was used to build a regression model, through partial correlation anal. and recursive feature elimination to select the optimal key influencing factors.The study revealed that the layer, cluster spacing, number of clusters, 40/70 mesh low-d. ceramsite (medium sand), and total proppant are the key factors influencing sectional production, and they all have different effects on it.The random forest algorithm showed better prediction capacity than the other algorithms.Its coefficient of determination and root-mean-square error on the test set were 0.723 and 0.319, resp., which indicates that it is an effective approach and has good generalization ability.The prediction results of the productivity regression model based on the random forest algorithm, combined with the trend surface response anal., were used to obtain the optimal values of the six key fracturing parameters of the unfractured well.

01 Dec 2025·Functional & Integrative Genomics

Barley stripe mosaic virus-induced gene silencing for functional validation of abiotic stress in barley

Review

Author: Wudu, Maru ; Admas, Tayachew ; Berhanie, Hailu

The barley stripe mosaic virus (BSMV) uses its genomic RNA components (alpha, beta, and gamma) as an efficient method for studying gene functions. It is a newly developed method that utilizes gene transcript suppression to determine the role of plant genes. BSMV derived from virus induced gene silencing (VIGS) is capable of infecting various key farming crops like barley, wheat, rice, corn, and oats. Nevertheless, the growing acceptance and enhancement of BSMV-VIGS will benefit all kinds of plants. Abiotic stresses such as drought and salt are highly affecting plant growth, development, and production. BSMV-induced temporal gene knockdown is performed during particular stressful situations to determine their specific function. The quick physiological and biochemical changes aid in confirming the role of the target genes. VIGS has a significant role to improve crop genetics and breeding, despite having certain restrictions. Thus, exploring the possible solution and addressing these difficulties will enhance the technology in the continuous advancement of plant manufacturing. BSMV-mediated VIGS has become popular in functional genomics; gene function can be determined without permanent transformation. In general, BSMV-mediated VIGS will be very helpful in the ongoing effort to develop resilient crops.

01 Jul 2025·Separation and Purification Technology

Hydrophobically modified hyperbranched polymer and its demulsification performance in W/O emulsion

Author: Ding, Yu ; Liu, Guoyun ; Jin, Baiyun ; Li, Zhoucheng ; Liu, Hanjun ; Liu, Huanyu ; Mi, Yuanzhu ; Ma, Wentao ; Jiang, Xuebin ; Yan, Xuemin

The separation of water-in-oil (W/O) emulsion causes a major problem in the process of crude oil extractionTo address this challenge, amphipathic hyperbranched polymer demulsifiers were developed, incorporating dendritic polyamide-amine as the hydrophilic core and alkyl glycidyl ether as hydrophobic branch.This structure allows for switching the amphiphilicity of demulsifiers by regulating the length of hydrophobic branch, thereby achieving the demulsification of W/O emulsion.Specifically, the demulsification experiments showed that at a concentration of 500 mg/L, TEM₈ demulsifier achieved a demulsification efficiency (DE) of 100 % within 150 min at 45 °C.Moreover, it also had superior DE across a wide pH value from 4 to 12.Interfacial characteristic experiments -including three-phase contact angle (TCA), surface tension (SFT), dynamic interfacial tension (IFT) and viscoelasticity modulus (VM)- were performed to elucidate the demulsification mechanism.In summary, TEM₈ effectively reduces interfacial tension and substitutes the natural surfactants at oil-water interface.This causes the rupture of interfacial film and coalescence of droplets, which facilitates demulsification.These findings highlight the potential of the hyperbranched polymer demulsifier for the effective separation of W/O emulsions at low temperature, suggesting its promising applications in advanced water-oil separation

100 Deals associated with Yangtze University

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100 Translational Medicine associated with Yangtze University

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Pipeline

Pipeline Snapshot as of 24 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Resolvin D1 ( IL-6 x STAT3 )	Colorectal Cancer More	Preclinical
CD38/BCMA Targeting CAR-T (Yangtze University) ( BCMA x CD38 )	Multiple Myeloma More	Preclinical