Article
Author: Sierra-Zorita, Radames ; Schreiber, Karen ; La Torre, Ignacio García-De ; Madu, Nwankwo Henry ; Javaid, Mahnoor ; Loarce-Martos, Jesús ; Iannone, Florenzo ; Ghodke, Akanksha ; Llerena, Gil Alberto Reyes ; Sainaghi, Pier Paolo ; Olaosebikan, Hakeem ; Ziade, Nelly ; Lini, Daniele ; Fabiola, Atzeni ; Cansu, Döndü Üsküdar ; Chávez, Nilmo ; Orsolini, Giovanni ; Campagne, Julien ; Cabriza, Karoll ; Sharma, Aman ; Quartuccio, Luca ; R, Naveen ; Govoni, Marcello ; Venerito, Vincenzo ; Edgar Gracia-Ramos, Abraham ; Colunga-Pedraza, Iris J ; Langguth, Daman ; Akarawatcharangura Goo, Phonpen ; Nunez, Lilith Stange ; Wibowo, Suryo Anggoro Kusumo ; Patel, Aarat ; Tehozol, Erick Adrian Zamora ; Phatak, Sanat ; Maurier, François ; Danielli, Maria Giovanna ; Andreoli, Laura ; Hudson, Marie ; Idania, Escalante M ; Singh, Yogesh Preet ; Dey, Dzifa ; Ajmani, Sajal ; Day, Jessica ; Jain, Avinash ; Joshi, Mrudula ; Aranega, Raquel ; Lilleker, James B ; Sambataro, Gianluca ; Pimentel, Victorio ; Gupta, Vikas ; Franceschini, Franco ; Parisi, Simone ; Losanto, Jonathan ; Sebastiani, Marco ; Mohammed, Reem Hamdy A ; Parodis, Ioannis ; Kuwana, Masataka ; Zimba, Olena ; So, Ho ; Yaadav, Praggya ; Gono, Takahisa ; Kardeş, Sinan ; Silva, José António Pereira ; Nakashima, Ran ; Arrieta, Dina ; Gupta, Latika ; Shinjo, Samuel Katsuyuki ; Nagy-Vincze, Melinda ; Cavagna, Lorenzo ; Griger, Zoltán ; Vaidya, Binit ; Pauling, John D ; Gaur, Prithvi Sanjeevkumar ; Giollo, Alessandro ; Cachafeiro-Vilar, Antonio ; Prieto-González, Sergio ; Makol, Ashima ; Fathi, Hanan Mohamed ; Ranjan, Rajiv ; Alunno, Alessia ; Serrano, Jorge Rojas ; Chowdhury, Abhra Chandra ; Agarwal, Vikas ; Ho, Enrique Julio Giraldo ; Quezada, Ivonne ; Srivastav, Nilesh ; Fusaro, Enrico ; Shenoy, Padnamabha ; Ima-Edomwonyi, Uyi ; Agarwal, Vishwesh ; Traboco, Lisa S ; Cristian, Vergara M ; Chinchay, Lyn ; Gheita, Tamer A ; Tan, Chou Luan ; Bernaola, José Proaño ; Pandya, Sapan C ; Mathew, Ashish Jacob ; Ordóñez, Andrea Bran ; Gasparyan, Armen Yuri ; Tomaras, Stylianos ; Fazal, Zoha Zahid ; Shukla, Anuj ; Nune, Arvind ; Palalane, Elisa ; Sen, Parikshit ; Yerima, Abubakar ; Hidalgo, Eduardo Romero ; Hmamouchi, Ihsane ; Kaneko, Yuko ; Giannini, Margherita ; Jagtap, Kshitij ; Wincup, Chris ; Chatterjee, Tulika ; Salim, Babur ; Shaharir, Syahrul Sazliyana ; Barman, Bhupen ; Pande, Arunkumar R ; Fuentes-Silva, Yurilís ; Cajas, Javier ; Salinas, Rodrigo García ; Airenakho, Emorinken ; Bohdana, Doskaliuk ; Yoshida, Akira ; Koussougbo, Ouma Devi ; Velikova, Tsvetelina ; Pastelin, Carlos Benito Santiago ; Alonzo, Hugo ; Ugarte-Gil, Manuel Francisco ; Milchert, Marcin ; Tan, Ai Lyn ; Mamadapur, Mahabaleshwar ; Harifi, Ghita ; Holzer, Marie-Therese ; Fornaro, Marco ; Bocci, Elena Bartoloni ; Caballero-Uribe, Carlo V ; Yıldırım, Reşit ; Asranna, Ajay ; Meyer, Alain ; El bouchti, Imane ; Saavedra, Miguel A ; Bautista, Generoso Guerra ; Chandwar, Kunal ; Chinoy, Hector ; Calapaqui, Wendy ; Del Papa, Nicoletta ; Colaman, Nelly ; Shumnalieva, Russka ; Del Vescovo, Sergio ; Proft, Fabian Nikolai ; Grignaschi, Silvia ; Zuleta, Wilmer Gerardo Rojas ; Katchamart, Wanruchada ; Gromova, Margarita Aleksandrovna ; Distler, Oliver ; Fonseca, João Eurico ; Saha, Sreoshy ; Kimura, Naoki ; Limaye, Vidya ; Darooka, Naitica ; Merayo-Chalico, Javier ; Obiols, Alejandro Quiñónez ; Landon-Cardinal, Océane ; Saenz, Ricardo ; Sebastiani, Gian Domenico ; Dedeke, Ibukunoluwa ; Okwara, Celestine Chibuzo ; Chen, Yi-Ming ; Pilania, Rakesh Kumar ; Baba, Zineb ; Manesh, Manoj M ; El Kibbi, Lina ; Aharonov, Or ; Hasan, A T M Tanveer ; Arredondo, Gabriela ; Knitza, Johannes ; De Angelis, Rossella ; Sato, Shinji ; Bommakanti, Keerthi Talari ; Patro, Pradeepta Sekhar ; Becky, A ; Gutiérrez, Carlos Enrique Toro ; Needham, Merrilee ; Kavadichanda, Chengappa G ; Báez, Jossiell Then ; Goswami, Rudra Prosad ; Halabi, Hussein ; Hoff, Leonardo Santos ; Arbeláez, Álvaro
AbstractObjectivesTo comprehensively compare the disease burden among patients with RA, PsA and AS using Patient-Reported Outcome Measurement Information System (PROMIS) scores and to identify distinct patient clusters based on comorbidity profiles and PROMIS outcomes.MethodsData from the global COVID-19 Vaccination in Autoimmune Diseases (COVAD) 2 e-survey were analysed. Patients with RA, PsA or AS undergoing treatment with DMARDs were included. PROMIS scores (global physical health, global mental health, fatigue 4a and physical function short form 10a), comorbidities and other variables were compared among the three groups, stratified by disease activity status. Unsupervised hierarchical clustering with eXtreme Gradient Boosting feature importance analysis was performed to identify patient subgroups based on comorbidity profiles and PROMIS outcomes.ResultsThe study included 2561 patients (1907 RA, 311 PsA, 343 AS). After adjusting for demographic factors, no significant differences in PROMIS scores were observed among the three groups, regardless of disease activity status. Clustering analysis identified four distinct patient groups: low burden, comorbid PsA/AS, low burden with depression and high-burden RA. Feature importance analysis revealed PROMIS global physical health as the strongest determinant of cluster assignment, followed by depression and diagnosis. The comorbid PsA/AS and high-burden RA clusters showed a higher prevalence of comorbidities (56.47% and 69.7%, respectively) and depression (41.18% and 41.67%, respectively), along with poorer PROMIS outcomes.ConclusionDisease burden in inflammatory arthritis is determined by a complex interplay of factors, with physical health status and depression playing crucial roles. The identification of distinct patient clusters suggests the need for a paradigm shift towards more integrated care approaches that equally emphasize physical and mental health, regardless of the underlying diagnosis.