Guilin Huaxin Pharmacy Co. Ltd.

To compare the differences in absorption extent and rate between the fexofenadine hydrochloride dry suspension (30 mg) provided by Guilin Huaxin Pharmaceutical Co., Ltd. and the fexofenadine hydrochloride dry syrup (trade name: Allegra®, specification: 30 mg/0.6 g) produced by Sanofi Co., Ltd. under fasting and postprandial administration in healthy Chinese people, and to evaluate the safety of the fexofenadine hydrochloride dry suspension produced by Guilin Huaxin Pharmaceutical Co., Ltd.

To investigate the pharmacokinetic characteristics of a single oral dose of Perindopril Amlodipine Tablets (III) produced by Guilin Huaxin Pharmaceutical Co., Ltd. [Test preparation T, specification: each tablet contains 10 mg of perindopril arginine and 5 mg of amlodipine besylate (calculated as amlodipine)] or Perindopril Amlodipine Tablets (III) certified by Les Laboratoires Servier [Reference preparation R, trade name: Kaisuda®, specification: each tablet contains 10 mg of perindopril arginine and 5 mg of amlodipine besylate (calculated as amlodipine)] in healthy subjects under postprandial conditions, evaluate the bioequivalence and safety of the two preparations, and provide a basis for the registration application of the test preparation.

This study used metoprolol succinate sustained-release capsules (specification: 100 mg (based on metoprolol tartrate)) developed by Guilin Huaxin Pharmaceutical Co., Ltd. as the test preparation. According to the relevant provisions of bioequivalence studies, metoprolol succinate sustained-release capsules (specification: 100 mg (based on metoprolol tartrate), trade name: Kapspargo Sprinkle®) produced by Ohm Laboratories Inc., with the license holder being Sun Pharmaceutical Industries, Inc., were used as the reference preparation to evaluate the bioequivalence of the test preparation and the reference preparation after administration under fasting/postprandial conditions. Secondary objective: To observe the safety of the test preparation metoprolol succinate sustained-release capsules and the reference preparation metoprolol succinate sustained-release capsules (Kapspargo Sprinkle®) in healthy subjects.