Delving into the Latest Updates on Anhui Medical University No. 1 Affiliated Hospital with Synapse

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IL-13Rα2(Interleukin-13 receptor subunit alpha-2)	1

Author: Jiang, Hui ; Zou, Yundong ; Zhang, Xuejun ; Lai, Luhua ; Du, Yan ; Zhang, Tao ; Klareskog, Lars ; Xu, Xun ; Yang, Yue ; Liang, Hao ; Sun, Liangdan ; Liu, Xu ; Zhang, Yuanwei ; Liu, Mengru ; Su, Yin ; Cao, Hongzhi ; Yang, Huanjie ; Jia, Huijue ; Hou, Yong ; Liu, Liang ; Mo, Xiaodong ; Guo, Jianping ; Liu, Xin ; Li, Zhanguo ; Sun, Xiaolin ; Padyukov, Leonid ; Yang, Huanming ; Wu, Xinyu ; Wang, Jian ; Zhang, Mingrong ; Li, Xiaowei ; Yamamoto, Kazuhiko ; Hu, Fanlei ; Wang, Yuxuan ; Zhang, Xuewu

ObjectiveThe strong genetic contribution of the major histocompatibility complex (MHC) region to rheumatoid arthritis (RA) has been generally attributed to human leukocyte antigen (HLA)-DRB1. However, due to the high polymorphisms and linkage disequilibrium within MHC, it is difficult to define novel and/or independent genetic risks using conventional HLA genotyping or chip-based microarray technology. This study aimed to identify novel RA risk variants by performing deep sequencing for MHC.MethodsWe first conducted target sequencing for the entire MHC region in 357 anticitrullinated protein antibodies (ACPA)-positive patients with RA and 1001 healthy controls, and then performed HLA typing in an independent case–control cohort consisting of 1415 samples for validation. All study subjects were Han Chinese. Genetic associations for RA susceptibility and severity were analysed. Comparative modelling was constructed to predict potential functions for the newly discovered RA association variants.ResultsHLA-DQα1:160D conferred the strongest and independent susceptibility to ACPA-positive RA (p=6.16×10−36, OR=2.29). DRβ1:37N had an independent protective effect (p=5.81×10−16, OR=0.49). As predicted by comparative modelling, the negatively charged DQα1:160D stabilises the dimer of dimers, thus may lead to an increased T cell activation. The negatively charged DRβ1:37N encoding alleles preferentially bind with epitope P9 arginine, thus may result in a decreased RA susceptibility.ConclusionsWe provide the first evidence that HLA-DQα1:160D, instead ofHLA-DRB1*0405, is the strongest and independent genetic risk for ACPA-positive RA in Han Chinese. Our study also illustrates the value of deep sequencing for fine-mapping disease risk variants in the MHC region.

Zhongguo Dongmai Yinghua Zazhi

Status of free radicals and their scavenging enzymes in patients with acute myocardial infarction

Author: Shi, Xuegong ; Li, Qin ; Liu, Hejun ; Wang, Taiping

The markers of polymorphonuclear (PMN) oxygen free radical (OFR) production, lipid peroxidation (malonyldialdehyde, MDA) and defenses against oxidative stress were studied in the patients with acute myocardial infarction (AMI).A convenient and sensitive method for PMN OFR production was assayed by polymorphonuclear chemiluminescence (PMN-CL).The parameters of PMN-CL, the plasma MDA concentration, the plasma activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX) were detected in 60 AMI patients and 62 age-matched healthy subjects.Patients with AMI showed significantly increased PMN-CL parameters, including chemiluminescence peak value, integration, and phagocytic index as compared to those in the healthy controls.The plasma MDA concentration increased in AMI patients compared with that in healthy controls.The PMN-CL peak value correlated best with plasma MDA concentration and neg. correlated with the plasma activity of SOD.The PMN act as a potential contributor to extension of myocardial necrosis induced by OFR, thereby indicating the involvement of free radicals in AMI.

100 Deals associated with Anhui Medical University No. 1 Affiliated Hospital

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100 Translational Medicine associated with Anhui Medical University No. 1 Affiliated Hospital

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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