Feasibility study for randomised controlled trial of Custodiol-HTK vs St Thomas’ solution for cardioplegia and cold static storage of UK donor hearts in cardiac transplantation (F-CUSToS)

Start Date14 Oct 2024

Sponsor / Collaborator

Papworth Hospital Nhs Foundation Trust Charity

NCT06433960 / RecruitingNot ApplicableIIT

A Cross-Sectional Study and a Novel Screening Survey for Radial Artery Assessment in Surgical Coronary Revascularisation

The goal of this observational study is to learn about how screening tests inform the radial artery (RA) suitability for harvesting and coronary bypass grafting in adults with ischaemic heart disease. The main question it aims to answer is:
• What factors influence the diagnostic accuracy of RA screening in patients undergoing surgical coronary revascularisation?
Participants will:
* Receive an assessment of their RA through routinely used techniques (Modified Allen Test +/- pulse-oximetry, Barbeau Test and Ultrasound examination)
* Answer a symptoms scale about their physical experience after surgery

Start Date10 Jul 2024

Sponsor / Collaborator

Papworth Hospital Nhs Foundation Trust Charity

NCT06386185 / Not yet recruitingNot ApplicableIIT

Developing the Probability Algorithm for Pulmonary Hypertension Echocardiography

The goal of this observational study is to assess the efficacy that the addition of novel markers cardiac function, particularly of right ventricular (RV) function in echocardiography, and ECG have in detecting pulmonary hypertension.
The main questions it aims to answer are:
Can novel markers in ECG and echocardiography suggest the presence of PH? Can existing screening guidelines be improved with the addition of these markers?

Start Date01 Jul 2024

Sponsor / Collaborator

Sheffield Teaching Hospitals NHS Foundation Trust

[+4]

100 Clinical Results associated with Papworth Hospital Nhs Foundation Trust Charity

0 Patents (Medical) associated with Papworth Hospital Nhs Foundation Trust Charity

2,455

Literatures (Medical) associated with Papworth Hospital Nhs Foundation Trust Charity

01 Jun 2024·Heart Rhythm

Predictive value of the PRAETORIAN score for defibrillation test success in patients with subcutaneous ICD: A subanalysis of the PRAETORIAN-DFT trial

Article

Author: Smeding, Lonneke ; Manyam, Harish ; Cassidy, Christopher J ; Bijsterveld, Nick R ; Martin, Claire A ; Defaye, Pascal ; Knops, Reinoud E ; Marquie, Christelle ; Bracke, Frank A L E ; van der Stuijt, Willeke ; Wilde, Arthur A M ; Elders, Jan ; de Jong, Jonas S S G ; Maass, Alexander H ; Shaik, Naushad A ; Marijon, Eloi ; El-Chami, Mikhael F ; Probst, Vincent ; Burke, Martin C ; Boersma, Lucas V A ; Zaidi, Amir ; Field, Duncan C ; Arya, Anita ; Demming, Thomas ; de Veld, Jolien A ; Quast, Anne-Floor B E ; Glikson, Michael ; Borger van der Burg, Alida E ; Lewis, Nigel ; Boveda, Serge ; Golovchiner, Gregory ; Kaiser, Lukas ; Tilz, Roland R ; Brouwer, Tom F ; Kuschyk, Jürgen ; van Woerkens, Léon J P M ; Lambiase, Pier D ; Betts, Timothy R ; Ghani, Abdul ; Nordbeck, Peter ; Pepplinkhuizen, Shari ; de Weger, Anouk ; Olde Nordkamp, Louise R A ; van Doorn, Dirk J ; Miller, Marc A

BACKGROUNDThe PRAETORIAN score estimates the risk of failure of subcutaneous implantable cardioverter-defibrillator (S-ICD) therapy by using generator and lead positioning on bidirectional chest radiographs. The PRospective randomized compArative trial of subcutanEous implanTable cardiOverter-defibrillatoR ImplANtation with and without DeFibrillation Testing (PRAETORIAN-DFT) investigates whether PRAETORIAN score calculation is noninferior to defibrillation testing (DFT) with regard to first shock efficacy in spontaneous events.OBJECTIVEThis prespecified subanalysis assessed the predictive value of the PRAETORIAN score for defibrillation success in induced ventricular arrhythmias.METHODSThis multicenter investigator-initiated trial randomized 965 patients between DFT and PRAETORIAN score calculation after de novo S-ICD implantation. Successful DFT was defined as conversion of induced ventricular arrhythmia in <5 seconds from shock delivery within 2 attempts. Bidirectional chest radiographs were obtained after implantation. The predictive value of the PRAETORIAN score for DFT success was calculated for patients in the DFT arm.RESULTSIn total, 482 patients were randomized to undergo DFT. Of these patients, 457 (95%) underwent DFT according to protocol, of whom 445 (97%) had successful DFT and 12 (3%) had failed DFT. A PRAETORIAN score of ≥90 had a positive predictive value of 25% for failed DFT, and a PRAETORIAN score of <90 had a negative predictive value of 99% for successful DFT. A PRAETORIAN score of ≥90 was the strongest independent predictor for failed DFT (odds ratio 33.77; confidence interval 6.13-279.95; P < .001).CONCLUSIONA PRAETORIAN score of <90 serves as a reliable indicator for DFT success in patients with S-ICD, and a PRAETORIAN score of ≥90 is a strong predictor for DFT failure.

01 May 2024·Nature Reviews Cardiology

Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention

Author: Subban, Vijayakumar ; Bourantas, Christos V ; Fracassi, Francesco ; Sankardas, Mullasari Ajit ; Yonetsu, Taishi ; Soeda, Tsunenari ; Kurihara, Osamu ; Weissman, Neil J ; Vergallo, Rocco ; Bryniarski, Krzysztof L ; Nakajima, Akihiro ; Prasad, Abhiram ; Kimura, Shigeki ; Fujimoto, James ; Yasuda, Satoshi ; Kim, Jung-Sun ; Shinke, Toshiro ; Lee, Tetsumin ; Saito, Yoshihiko ; Fuster, Valentin ; Garcia-Garcia, Hector M ; Akasaka, Takashi ; Yamamoto, Erika ; Niccoli, Giampaolo ; Cho, Jin Man ; Reynolds, Harmony ; Bouma, Brett ; Jang, Ik-Kyung ; Kini, Annapoorna S ; Narula, Jagat ; Raffel, O Christopher ; Kastrati, Adnan ; Adriaenssens, Tom ; Arbustini, Eloisa ; Araki, Makoto ; Yu, Bo ; Prati, Francesco ; Hong, Myeong-Ki ; Stone, Gregg W ; Granada, Juan F ; Montone, Rocco A ; Ali, Ziad ; Di Mario, Carlo ; Finn, Aloke V ; Aguirre, Aaron D ; Escaned, Javier ; Minami, Yoshiyasu ; Weisz, Giora ; Saw, Jacqueline ; Mizuno, Kyoichi ; Porto, Italo ; Sugiyama, Tomoyo ; Nicholls, Stephen J ; Lee, Hang ; Thondapu, Vikas ; Kume, Teruyoshi ; West, Nick E J ; Johnson, Thomas W ; Mintz, Gary S ; Hibi, Kiyoshi ; Kakuta, Tsunekazu ; Räber, Lorenz ; Lerman, Amir ; Nef, Holger ; Toutouzas, Konstantinos ; Dauerman, Harold L ; Tearney, Guillermo J ; Croce, Kevin ; Park, Seung-Jung ; Iannaccone, Mario ; Nakamura, Sunao ; Russo, Michele ; Kubo, Takashi ; Crea, Filippo ; Holm, Niels Ramsing ; Park, Sangjoon ; Gori, Tommaso ; Feldman, Marc ; Libby, Peter ; Rioufol, Gilles ; Waksman, Ron ; Gonzalo, Nieves ; Tanaka, Atsushi ; Michalis, Lampros K ; Regar, Evelyn ; Jang, Yangsoo ; Pinto, Fausto J ; Uemura, Shiro ; Barlis, Peter ; Guagliumi, Giulio ; Di Vito, Luca ; Meneveau, Nicolas ; Arbab-Zadeh, Armin ; Joner, Michael ; Virmani, Renu ; Amabile, Nicolas ; Yan, Bryan P ; Daemen, Joost ; McNulty, Iris ; Chen, Yundai ; Higuma, Takumi ; Kim, Hyung Oh ; Seegers, Lena M ; Gili, Sebastiano ; Alfonso, Fernando ; Maehara, Akiko ; Wijns, William ; Opolski, Maksymilian P ; Gerbaud, Edouard ; Ye, Jong Chul ; Papafaklis, Michail I ; Souteyrand, Geraud ; Takano, Masamichi ; Dijkstra, Jouke

01 May 2024·Radiologic Clinics of North America

Pretranscatheter and Posttranscatheter Valve Planning with Computed Tomography

Review

Author: Rajani, Ronak ; Clifford, Thomas ; Androshchuk, Vitaliy ; Weir-McCall, Jonathan R

The range of potential transcatheter solutions to valve disease is increasing, bringing treatment options to those in whom surgery confers prohibitively high risk. As the range of devices and their indications grow, so too will the demand for procedural planning. Computed tomography will continue to enable this growth through the provision of accurate device sizing and procedural risk assessment.

100 Deals associated with Papworth Hospital Nhs Foundation Trust Charity

100 Translational Medicine associated with Papworth Hospital Nhs Foundation Trust Charity

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