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Last update 23 Jan 2025

SN Medical College, Agra

Last update 23 Jan 2025

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Pipeline

Deal

Translational Medicine

Overview

Clinical Trials associated with SN Medical College, Agra

NCT05040126

/ Active, not recruitingPhase 3IIT

Evaluate the Effectiveness, Safety and Tolerability of Various Doses of Linezolid in Combination With Bedaquiline and Pretomanid in Adults With Pre-Extensively Drug-Resistant (Pre-XDR), Or Treatment Intolerant/Non-responsive Multidrug-Resistant (MDRTI/NR) Pulmonary Tuberculosis in India

Existing problem with DR TB management:
Injectable regimens for longer duration with toxicity Poor adherence, treatment failures, continued transmission
Need of the study:
Oral regimens of shorter duration Improved treatment adherence Implementation of community-based models of care Reduction in direct costs and indirect costs of patients Improved treatment outcomes
Need for shorter, tolerable and effective regimen
Hence modified BPaL regimen is designed to study the newer shorter oral in varying doses of Linezolid for pre XDR Tb patients and MDR TI/NR patients

Start Date07 Oct 2021

Sponsor / Collaborator

SN Medical College, Agra

[+1]

CTRI/2020/12/029868

/ Not yet recruitingNot ApplicableIIT

An observational Study to Asses mRNA expression levels of Blimp1 alpha and beta in SARSCoV-2 infected subjects

Start Date23 Dec 2020

Sponsor / Collaborator

SN Medical College, Agra

CTRI/2020/08/027038

/ Not yet recruitingPhase 3IIT

A Prospective ,randomized ,double blind,placebo controlled study to access effects of nano ozonized hydrogen peroxide nebulization on results of RTPCR for noval corona virus thus infectivity and clinical course among mild to moderate sick Covid 19 patients HOPE in Covid 19(Hydrogen Peroxide Inhalation).

Start Date20 Aug 2020

Sponsor / Collaborator

SN Medical College, Agra

100 Clinical Results associated with SN Medical College, Agra

0 Patents (Medical) associated with SN Medical College, Agra

Literatures (Medical) associated with SN Medical College, Agra

01 Nov 2024·INDIAN JOURNAL OF APPLIED RESEARCH

IMMUNOHISTOCHEMICAL EVALUATION OF P16 AND KI-67 IN PREMALIGNANT AND MALIGNANT LESIONS OF UTERINE CERVIX

Author: Yadav, Poonam ; Rani, Deepa ; Uz Zama, Qamar ; Saxena, Prachi ; Agarwal, Pooja

Introduction - Cervical cancer remains a significant public health concern worldwide, with premalignant lesions progressing to invasive carcinoma over time. The biomarkers P16 and Ki-67 have emerged as valuable tools for identifying and characterizing these lesions due to their roles in cell cycle regulation and proliferation. This study aimed to Objectives - investigate the expression patterns of p16 and Ki67 in premalignant and malignant cervical lesions. Specific objectives included categorizing the lesions as HPV Associated and HPV Independent on the basis of p16 immunoexpression and to compare their histomorphological correlation. Study also has an objective to find out the dual positivity of p16 and Ki67 in premalignant and malignant lesions of cervix to improve the diagnostic accuracy of cervical lesions. A retrospective observational study was conducted involving Methods- histopathological samples from patients diagnosed with various stages of cervical lesions. Immunohistochemical staining for p16 and Ki67 was performed, and semiquantitative method was used for scoring. These were then analyzed using statistical methods. Resul Results- ts showed that p16 expression was positive in 71.42 % of premalignant and 98.61 % of malignant cases. Ki67 positivity was noted in 85.71 % of premalignant and 88.88 % of malignant cases. Dual positivity was found in 71.42% of premalignant and 88.88% of malignant cases. HPV Association was found in 98.61 % of malignant lesions and HPV Independent lesions were found to be 1.39 %. There was no significant correlation found in histomorphology of HPV associated or HPV Independent lesions. It was concluded that p16 and Ki67 positivity increased w Conclusion- hen the grade of lesion increased from premalignancy to malignancy and that dual positivity of these biomarkers could help in increasing the diagnostic accuracy of cervical lesions.

01 Nov 2024·INDIAN JOURNAL OF APPLIED RESEARCH

IMMUNOHISTOCHEMICAL EVALUATION OF P16 AND Ki67 IN PREMALIGNANT AND MALIGNANT LESIONS OF ORAL CAVITY

Author: Saxena, Prachi ; Pratap Singh, Akhil ; Goel, Aparajita ; Uz Zama, Qamar ; Agarwal, Pooja

Introduction: Oral cancer is one of the top three types of cancer in the India. Cell cycle protein P16 along with proliferation marker Ki67 provide significant assistance in grading OSCC. Ki67 marker also used to determine the tumor behavior, prognosis which plays a major role in deciding the treatment modalities. AIM: Immunohistochemical evaluation of p16 and ki67 in premalignant and malignant lesions of oral cavity. The cross-sectional study was conducted Material and Method: in the Department of Pathology in collaboration with the Department of ENT at Sarojini Naidu Medical College, Agra, Uttar Pradesh, India over a period of 18 months from September 2022 to May 2024. A total 155 histopathologically diagnosed cases were included out of which 23 cases were premalignant and 132 cases were malignant. Post operative specimens were fixed in 10% neutral buffered formalin. The initial diagnosis was made by Haematoxylin and Eosin (H&E) stained tissue sections. Sections from the same block were subjected to IHC Staining antibody to p16 and ki67 antigen. The data was entered into Microsoft Excel 2016 and analysed using Statistical Package for Social Sciences (SPSS) statistical software version 23. The inferential statistics included the use of the Chi-square test. Results: It was observed that p16 immunoexpression increased with increase in histological grades. We observed that percentage of cases were inversely proportional to the immunohistochemical grading .We observed that Ki-67 immunoexpression was more in malignant cases than premalignant. Conclusion: Higher histological grades indicate higher P16 and Ki67 expression while they were not associated with age, gender and site of lesion. Dual positivity is higher among PDSCC cases (66.67%) followed by MDSCC cases (50.0%), also shows the staining intensity of Grade 2 further showing the higher invasiveness when follow up clinically. P16 is widely used as a surrogate biomarker for HPV infection and its expression is the most important immunohistochemical marker to differentiate HPV negative and HPV positive OSCC for better management of patients. Ki-67 antigen is a proliferative marker used to determine the tumor behavior, prognosis which plays a major role in deciding the treatment modalities. Thus investigation of IHC marker panels with clinicopathological parameters can be helpful for better assessment of patients with Oral premalignant and malignant lesions.

01 Nov 2024·INDIAN JOURNAL OF APPLIED RESEARCH

DIAGNOSIS OF THYROID NODULES BY BETHESDA SYSTEM FOR REPORTING THYROID CYTOPATHOLOGY AIDED WITH IMMUNOCYTOCHEMISTRY

Author: Singh, Himani ; Nagayach, Pooja ; Rani, Deepa ; Singh, Akhil Pratap ; Singh, Prashant ; Chandrakanta, Chandrakanta

Introduction: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) provides a standardized framework for classifying thyroid nodule fine-needle aspiration (FNA) cytology results in management and risk stratification of thyroid nodules. Despite its utility, Indeterminate Categories pose diagnostic challenges. Immunocytochemistry (ICC) offers potential solutions by using specific markers to distinguish between benign and malignant nodules. 1. Objectives: Analyze the cytological features and group the thyroid cytopathological reports based on the diagnostic criteria of Bethesda system for reporting thyroid cytopathology. 2. Use of immunocytochemistry (CK-19 and Galectin 3) for differential diagnosis of Indeterminate follicular patterned thyroid smears and whenever required for the diagnosis. 3. Analyze whether cytopathological diagnosis correlated with the histopathological diagnosis in cases where biopsy specimens were available. A cross-sectional study was done on 143 patients with thyroi Methods: d nodule. FNA was done on all the patients and cytological diagnosis were made by using TBSRTC and ICC was performed on Indeterminate Categories (III, IV, V) and histopathological correlation was done in cases wherever the surgical specimens were received. All Results: the patients were diagnosed according TBSRTC. Out of 143 patients Category I included 5 cases, Category II included 104 cases, Category III included 11 cases, Category IV included 12 cases, Category V included 6 cases, Category VI included 5 cases. On Category III, IV, V, ICC was done to differentiate Benign lesions from Malignant lesions and histopathological correlation was done. ROM was calculated for every Category. TBSRTC was Conclusion: reliable and reproducible and its diagnostic accuracy was increased by using ICC in conjugation with it.

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100 Translational Medicine associated with SN Medical College, Agra

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SN Medical College, Agra

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