Pantherna Therapeutics GmbH

Pantherna Therapeutics GmbH, a mRNA-lipid nanoparticle (LNP) platform company dedicated to the research and development of innovative mRNA-based therapeutics today announced a research collaboration with Bayer, investigating novel LNP-carriers for future mRNA therapies outside the liver. By combining their expertise in RNA therapeutics, both parties intend to identify novel LNP formulations that surpass the performance of conventional neutral LNPs as used in the mRNA vaccines. These advanced LNPs will be designed to potentially offer superior properties, ensuring the desired pharmacological outcomes and facilitating a smooth scalable translation towards development. Ansgar Santel, CEO of Pantherna Therapeutics, commented “Pantherna values Bayer’s trust in our technology and expertise. In collaboration, we will explore the potential of novel LNP formulations tailored to Bayer’s therapeutic interest, accelerating the pace of innovation and enhancing patient care. We look forward to partnering with the Bayer Non-Viral Delivery team.” Contact

Hennigsdorf, May 3, 2024 As of today, Ansgar Santel acts as the new Chief Executive Officer and becomes an additional member of the Board of Managing Directors at Pantherna Therapeutics GmbH with Jörg Kaufmann and Gerrit Maass. Ansgar joined Pantherna in November 2021 as Head of Translational Research and Alliance Management. He has a wealth of experience in developing new innovative RNA therapies whilst exhibiting exceptional leadership qualities. We at Pantherna are proud to welcome Ansgar into his new role as CEO and are confident in his commitment to accelerating Pantherna’s innovation and success in the development of impactful RNA therapies. Contact for additional information:   Dr. Ansgar Santel, CEO T: +49(0)3302-202 240-0  E-Mail: a.santel@pantherna-therapeutics.com  

PRESS RELEASE Joint Press Release by WACKER and Pantherna Therapeutics Number 9 Munich/Hennigsdorf, April 5, 2024 – WACKER’s mRNA competence center in Halle is to produce an active ingredient based on mRNA and lipid nanoparticles (LNPs) for combating acute respiratory distress syndrome (ARDS). Manufacture of the PAN004 active ingredient supplied by Pantherna Therapeutics, a biotech company, is based on a large-scale production process developed by WACKER for mRNA formulated in LNPs. This makes Pantherna WACKER’s first partner to receive preclinical material from its state-of-the-art production plant, which is set to go on stream in mid-2024. WACKER covers the entire production process – from starting material and plasmid DNA through to the mRNA LNP formulation and dispensed mRNA active. A competence center for active ingredients based on messenger ribonucleic acid (mRNA) will soon open at WACKER’s site in Halle. This site features four new production lines that Wacker Biotech GmbH, a fully owned subsidiary of Wacker Chemie AG, will use to contract manufacture mRNA vaccines, among other things. Part of the new capacity will be available to the German federal government as and when required as part of its pandemic preparedness contracts. Pantherna is the first partner to be supplied by the new facility in Halle. Dr. Guido Seidel, managing director of Wacker Biotech GmbH, said: “Early collaboration with Pantherna made it possible to develop a cost-effective and scalable process. This doesn’t often happen during preclinical stages in a CDMO setting. Close collaboration with our experts in Corporate R&D was the key to success here. The transfer of technology to our new production facility is now moving at full speed and we are certain that Pantherna will benefit from our manufacturing expertise.” Dr. Jörg Kaufmann, CSO of Pantherna Therapeutics, said: “We have established a very good collaborative R&D footing with WACKER and value its broad expertise in the production of mRNA active ingredients – expertise that we were able to use to turn our innovative technology into a product. WACKER plays a special role in the market, as it combines many years of experience in the toll manufacturing of complex biopharmaceuticals with the capabilities of its own Corporate R&D unit. We are delighted to now see our innovative mRNA active ingredient move from the laboratory to regulated production. This marks an important milestone for our company and opens a new chapter in our joint collaboration.” With sites in Halle, Jena, Amsterdam and San Diego, Wacker Biotech is a CDMO for the GMP-compliant production of active ingredients for the pharmaceutical industry. What’s more, the involvement of WACKER’s Munich-based Corporate R&D unit enables Wacker Biotech to work on the early development stages of active ingredients. Active ingredients from preclinical collaborations can subsequently be transferred to Wacker Biotech’s facilities for GMP production. For the first time in the mRNA field, this is now happening with Pantherna’s novel mRNA therapy development candidate PAN004 for combating acute respiratory distress syndrome (ARDS). Pantherna and Wacker Biotech have been collaborating since 2022. As part of a joint research project, both companies initially developed the manufacturing process for mRNA-based active ingredients using WACKER’s own process. The plasmid-based template DNA, yield and critical parameters were all optimized by focusing on process scalability. The LNP manufacturing process based on Pantherna’s proprietary LNP formulation technology PTXΔLNP® was transferred from Pantherna to Wacker Biotech as part of this project. The resultant mRNA formulations were, in turn, evaluated by Pantherna in a cell culture model. At the end of 2023, Pantherna decided to join Wacker Biotech in the large-scale production of an active ingredient based on mRNA and lipid nanoparticles for preclinical dose range finding studies as an initial major step toward translating Pantherna’s technology into clinical development. About Pantherna Therapeutics Pantherna Therapeutics GmbH develops novel first-in-class therapies based on mRNA for indications with high medical need. Pantherna’s therapeutic programs are based on two innovative and proprietary platform technologies, the mRNA expression constructs (PTXmRNA®) and necessary lipid nanoparticles (PTXΔLNP®) for cell type-specific expression of therapeutic proteins. PAN004 is Pantherna’s first development candidate to emerge from this platform and represents a defined mRNA-LNP formulation for the selective mRNA expression of a Tie2 agonist in the vascular endothelium of pulmonary capillaries. Pantherna is pursuing the development of a pipeline of novel mRNA-LNP candidates that will enable the therapeutic use of mRNA in various tissues and cell types. www.pantherna-therapeutics.com About Wacker Biotech Wacker Biotech GmbH, Wacker Biotech B.V. and Wacker Biotech US Inc. are full-service contract manufacturers of therapeutic proteins, live microbial products (LMPs), plasmid DNA (pDNA), messenger ribonucleic acid (mRNA) and vaccines based on microbial systems. Wacker Biotech’s portfolio extends from strain/process development and analytical testing through to production for clinical and commercial applications. Wacker Biotech operates three GMP- compliant, FDA- and EMA-certified production plants at its Jena and Halle sites in Germany and in Amsterdam in the Netherlands. In addition, Wacker Biotech has had a plant in San Diego (Wacker Biotech US Inc.) since February 2021. Wacker Biotech GmbH, Wacker Biotech B.V. and Wacker Biotech US Inc. are wholly owned subsidiaries of Munich-based Wacker Chemie AG. www.wacker.com/biologics Media relations