Humanetics Corp.

Presentation to update the advanced development of BIO 300, an orally available medical countermeasure for Warfighters, to prevent toxicities due to radiation exposure. MINNEAPOLIS--(BUSINESS WIRE)--Updates on the development of Humanetics Corporation’s (Humanetics) new drug candidate, BIO 300, were presented at the 2024 Military Health System Research Symposium (MHSRS), held August 26-29 th in Kissimmee, Florida. MHSRS is the foremost scientific meeting of the U.S. Department of Defense (DOD), focusing on the unique medical needs of warfighters. BIO 300 was originally developed as a radioprotectant by researchers at the Armed Forces Radiobiology Research Institute (AFRRI) in Bethesda, Maryland. It was exclusively licensed to Humanetics for advanced development and commercialization. Collaborative studies continue with DOD scientists to develop BIO 300 as an oral drug that warfighters can take to provide protection against the effects of radiation from a radiological or nuclear event. Key Highlights of the Presentation: Novel Formulation: An overview of the BIO 300, an orally available drug designed for ease of use and rapid administration in various military and commercial settings. Efficacy and Safety: Insights into the nonclinical studies demonstrating the compound’s ability to protect against Acute Radiation Syndrome (ARS) and its safety in animal models. Clinical Development Pathway: An outline of clinical data supporting BIO 300’s safety and efficacy, including the proposed plan for human dose conversion under the FDA animal rule. Ongoing Development Activities: A detailed overview of ongoing and future development activities to support planned regulatory submissions. This work highlighted on BIO 300 research has positioned it as one of the most advanced prophylactic medical countermeasures currently under development for ARS. Developing countermeasures that protect individuals, especially military personnel, against ARS is paramount, considering the current geopolitical environment fueling the real and increasing threat of nuclear or radiological events. “We are thrilled to share our progress on the advanced development of BIO 300,” said Michael Kaytor, Ph.D., Vice President of Research and Development at Humanetics. “This drug could transform our ability to protect the men and women who serve our country, and anyone who may be at risk of intentional or accidental radiation exposure.” In addition to its military applications, BIO 300 is being evaluated in phase 2 clinical trials to prevent normal tissue injury resulting from cancer radiotherapy and to reduce inflammatory lung damage (e.g., COVID-19, Idiopathic Pulmonary Fibrosis, acute respiratory distress syndrome). The research presented was supported in part by grants from the US Department of Defense’s Congressionally Directed Medical Research Program and an Other Transaction Authority agreement with the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND). The views expressed herein are those of Humanetics and may not reflect the official policy or position of the Department of Defense or the US Government. Reference herein to any specific commercial products, process, or service by trade name, trademark, manufacturer, or otherwise, does not constitute or imply its endorsement, recommendation, or favoring by the U.S. government and shall not be used for advertising or product endorsement purposes. About Humanetics Corporation Humanetics Corporation is a clinical-stage pharmaceutical company engaged in the accelerated discovery, development and commercialization of proprietary drugs in markets with urgent and unmet needs with a focus on radiation modulators for oncology and medical countermeasures. For more information, visit . Contacts Michael Kaytor VP – Research and Development mkaytor@humaneticscorp.com

MINNEAPOLIS--(BUSINESS WIRE)--Humanetics Corporation, an advanced clinical-stage specialty pharmaceutical company developing radioprotectant drugs for warfighters and cancer patients, will discuss BIO 300, its promising lead radioprotective drug candidate, at the BIO Investor Forum, Oct. 15-16, 2024. This event showcases drug development programs ready for partnering or venture funding, focusing on accelerating new therapeutic technologies into commercialization. It features panel discussions on policy, business, financing, and R&D, along with company presentations and BIO One-on-One Partnering™ meetings. The 2023 forum hosted over 1,600 partnering meetings. The conference takes place at the Fairmont Hotel in San Francisco. For more information: . About BIO 300 BIO 300 is a pioneering radioprotectant drug with dual military and medical applications. It’s designed as a prophylactic to protect normal tissues from radiation damage, distinguishing it from other drug candidates. The U.S. Department of Defense (DoD) has heavily funded and researched BIO 300 for its potential to mitigate radiation effects on warfighters and civilians in the event of a nuclear attack or radiological incident. The need for such a product has significantly increased due to current world events. Humanetics is working under a $25 million DoD contract to position BIO 300 for Emergency Use Authorization against Acute Radiation Syndrome (ARS). BIO 300 is also being studied to improve outcomes in cancer patients receiving radiotherapy with or without chemotherapy. These patients often suffer from unintended side effects that can reduce treatment efficacy or cause serious adverse events. Administered as an oral liquid nanosuspension, it may minimize normal tissue radiation damage without compromising tumor treatment efficacy. Positive Phase 1/2a results in non-small cell lung cancer patients undergoing chemoradiotherapy support its safety and potential clinical benefits. A Phase 2b trial of BIO 300 in patients with post-acute respiratory complications from severe COVID-19 has been completed. This randomized, double-blind, placebo-controlled study evaluated BIO 300’s safety and efficacy in improving lung function. Funded by the National Institute of Allergy and Infectious Disease (NIAID), results are expected by late 2024. About Humanetics Corporation Humanetics is an advanced clinical-stage specialty pharmaceutical company engaged in the development and commercialization of radioprotectant drugs to prevent harm caused by exposure to ionizing radiation; for protective use in cancer radiation therapy; and to guard against the long-term damaging effects of COVID-19. For more information, visit . Contacts Jason Brown Director, Investor Relations jbrown@humaneticscorp.com (612) 868-7009

MINNEAPOLIS, MN —October 1, 2024 - Humanetics Corporation, an advanced clinical-stage specialty pharmaceutical company developing radioprotectant drugs for warfighters and cancer patients, will discuss BIO 300, its promising lead radioprotective drug candidate, at the BIO Investor Forum, Oct. 15-16, 2024. This event showcases drug development programs ready for partnering or venture funding, focusing on accelerating new therapeutic technologies into commercialization. It features panel discussions on policy, business, financing, and R&D, along with company presentations and BIO One-on-One Partnering™ meetings. The 2023 forum hosted over 1,600 partnering meetings. The conference takes place at the Fairmont Hotel in San Francisco. For more information: https://bif.bio.org/. About BIO 300 BIO 300 is a pioneering radioprotectant drug with dual military and medical applications. It's designed as a prophylactic to protect normal tissues from radiation damage, distinguishing it from other drug candidates. The U.S. Department of Defense (DoD) has heavily funded and researched BIO 300 for its potential to mitigate radiation effects on warfighters and civilians in the event of a nuclear attack or radiological incident. The need for such a product has significantly increased due to current world events. Humanetics is working under a $25 million DoD contract to position BIO 300 for Emergency Use Authorization against Acute Radiation Syndrome (ARS). BIO 300 is also being studied to improve outcomes in cancer patients receiving radiotherapy with or without chemotherapy. These patients often suffer from unintended side effects that can reduce treatment efficacy or cause serious adverse events. Administered as an oral liquid nanosuspension, it may minimize normal tissue radiation damage without compromising tumor treatment efficacy. Positive Phase 1/2a results in non-small cell lung cancer patients undergoing chemoradiotherapy support its safety and potential clinical benefits. A Phase 2b trial of BIO 300 in patients with post-acute respiratory complications from severe COVID-19 has been completed. This randomized, double-blind, placebo-controlled study evaluated BIO 300's safety and efficacy in improving lung function. Funded by the National Institute of Allergy and Infectious Disease (NIAID), results are expected by late 2024. About Humanetics Corporation Humanetics is an advanced clinical-stage specialty pharmaceutical company engaged in the development and commercialization of radioprotectant drugs to prevent harm caused by exposure to ionizing radiation; for protective use in cancer radiation therapy; and to guard against the long-term damaging effects of COVID-19. For more information, visit www.humaneticscorp.com.