Delving into the Latest Updates on Patheon Development Services, Inc. with Synapse

Overview

Tags

Congenital Disorders

Immune System Diseases

Hemic and Lymphatic Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Hemic and Lymphatic Diseases	1
Infectious Diseases	1
Immune System Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

ITK(Tyrosine-protein kinase ITK/TSK)	1

The primary objectives of this study are to determine the safety and tolerability profile of CPI-818 at escalating dose levels; to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) of CPI-818 to select the expansion cohort dose (ECD); and to evaluate the safety and tolerability of CPI-818 in selected R/R T-cell lymphoma subjects.

Start Date17 Dec 2021

Sponsor / Collaborator

Corvus Pharmaceuticals, Inc.

[+2]

CTR20212109 / TerminatedPhase 1

ZN-d5单药用于中国非霍奇金淋巴瘤受试者的I期剂量递增研究

[Translation] A Phase I Dose-Escalation Study of ZN-d5 Monotherapy in Chinese Non-Hodgkin's Lymphoma Subjects

？评估ZN-d5在NHL受试者中的安全性和耐受性？确定NHL受试者的MTD和/或RP2D ？确定ZN-d5在NHL受试者中的PK特征？评估ZN-d5在HNL受试者中的临床活性

[Translation]

? Evaluate the safety and tolerability of ZN-d5 in NHL subjects ? Determine the MTD and/or RP2D in NHL subjects ? Determine the PK characteristics of ZN-d5 in NHL subjects ? Evaluate the clinical activity of ZN-d5 in HNL subjects

Start Date29 Sep 2021

Sponsor / Collaborator

Zentera Therapeutics (Shanghai) Co., Ltd.

[+2]

CTR20210533 / CompletedPhase 1

评价在健康受试者中伊曲康唑和利福平对ASC40药代动力学影响的I期开放、药物-药物相互作用研究

[Translation] A Phase I Open-label, Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole and Rifampicin on the Pharmacokinetics of ASC40 in Healthy Subjects

评估伊曲康唑（一种细胞色素P450 3A(CYP3A)的强抑制剂）在健康志愿者中对ASC40的药代动力学的影响；评估利福平（CYP3A的强诱导剂）在健康志愿者中对ASC40的药代动力学的影响；评估在健康志愿者中使用伊曲康唑和利福平时ASC40的安全性和耐受性。

[Translation]

To evaluate the effect of itraconazole, a strong inhibitor of cytochrome P450 3A (CYP3A), on the pharmacokinetics of ASC40 in healthy volunteers; to evaluate the effect of rifampicin, a strong inducer of CYP3A, on the pharmacokinetics of ASC40 in healthy volunteers; and to evaluate the safety and tolerability of ASC40 when itraconazole and rifampicin are used in healthy volunteers.

Start Date30 Mar 2021

Sponsor / Collaborator

Patheon Development Services, Inc.

[+2]

100 Clinical Results associated with Patheon Development Services, Inc.

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0 Patents (Medical) associated with Patheon Development Services, Inc.

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100 Deals associated with Patheon Development Services, Inc.

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100 Translational Medicine associated with Patheon Development Services, Inc.

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

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3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Soquelitinib ( ITK )	T-Cell Lymphoma More	Phase 1
Tigozertinib ( EGFR C797S x EGFR L858R x EGFR T790M x EGFR-Ex19del )	EGFR positive non-small cell lung cancer More	Suspended
Asaretoclax ( Bcl-2 )	Non-Hodgkin Lymphoma More	Discontinued
Denifanstat ( FASN )	Nonalcoholic Steatohepatitis More	Pending