Xinxiang Shuanglu Pharmaceutical Co., Ltd.

Main study objectives: To observe the pharmacokinetic characteristics of the test preparation bisoprolol amlodipine tablets (specifications: 5 mg bisoprolol fumarate and 5 mg amlodipine besylate (calculated as amlodipine), produced by Xinxiang Shuanglu Pharmaceutical Co., Ltd.) and the reference preparation bisoprolol amlodipine tablets (specifications: 5 mg bisoprolol fumarate and 5 mg amlodipine besylate (calculated as amlodipine); the licensee is Merck Kft.) after oral administration to healthy Chinese subjects under postprandial conditions, and to evaluate the bioequivalence of the two preparations in humans. Secondary study objectives: To observe the safety of the test preparation and the reference preparation bisoprolol amlodipine tablets in healthy adult subjects.

Main study objectives: To observe the pharmacokinetic characteristics of the test preparation bisoprolol amlodipine tablets (specifications: 5 mg bisoprolol fumarate and 5 mg amlodipine besylate (calculated as amlodipine), produced by Xinxiang Shuanglu Pharmaceutical Co., Ltd.) and the reference preparation bisoprolol amlodipine tablets (specifications: 5 mg bisoprolol fumarate and 5 mg amlodipine besylate (calculated as amlodipine); the licensee is Merck Kft.) after oral administration under fasting conditions in healthy Chinese subjects, and to evaluate the human bioequivalence of the two preparations. Secondary study objectives: To observe the safety of the test preparation and the reference preparation bisoprolol amlodipine tablets in healthy adult subjects.