Delving into the Latest Updates on The 1St Affiliated Hosp of Guangdong Pharm University with Synapse

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BACKGROUNDEvidence suggests that emotional status affect physical health. We aimed to investigate the association of different emotional support sources with morbidity or mortality of cardio-cerebrovascular diseases (CVDs).METHODSWe conducted a retrospective-cohort analysis using data in National Health and Nutrition Examination Survey from 1999 to 2004. 6183 participants were included and categorized into significant others support group (SOG, n = 2999) and experientially similar others support group (ESG, n = 3184) according to self-report questionnaire. Propensity score matching (PSM) was used to eliminate group difference. Pearson's Chi-square test, Kaplan-Meier survival analysis and generalized linear model were used to calculate and estimate associations between mortality, CVDs morbidity and emotional support sources.RESULTSParticipants receiving more support from experientially similar others had significant lower morbidity of myocardial infarction (MI, OR = 0.86) and all-cause mortality (OR = 0.81) after PSM compared to SOG. Subgroup analysis after PSM also showed that more emotional support from experientially similar others can significantly reduce all-cause mortality, especially in women and people over 60 years old.LIMITATIONSRetrospective-cohort analysis and limited sample size.CONCLUSIONCompared with participants receiving more emotional support from family members, receiving more emotional support from other relative, neighbors, co-workers, church and club members, professionals and friends significantly reduced all-cause mortality as well as MI morbidity.

02 Jan 2025·Theranostics

Ultrasound-activated erythrocyte membrane-camouflaged Pt (II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death

Article

Author: Wu, Yanjie ; Li, Mengqi ; Wu, Ting ; Liu, Cong ; Luo, Yi ; Wang, Hong ; Liang, Xiaochen ; Zhang, Weijin ; Li, Wengang ; Zhao, Ting ; Wang, Yunjie ; Zeng, Wei ; Li, Tingting ; Liu, Wei ; Luo, Xian ; Ke, Zhihai ; Ma, Mengli ; Li, Wanyun ; Wang, Shengyu ; Luo, Fanghong ; Zhao, Zhiyu

Rationale: Immunogenic cell death (ICD) offers a promising avenue for the treatment of triple-negative breast cancer (TNBC). However, optimizing immune responses remains a formidable challenge. This study presents the design of RBCm@Pt-CoNi layered double hydroxide (RmPLH), an innovative sonosensitizer for sonodynamic therapy (SDT), aimed at enhancing the efficacy of programmed cell death protein 1 (PD-1) inhibitors by inducing robust ICD responses. Methods: Pt-CoNi layered double hydroxide (LDH) nanocages were synthesized using a two-step method, followed by functionalization with red blood cell membranes to prepare RmPLH. The in vitro assessments included evaluations of cell toxicity, cellular uptake, and sonodynamic effects of RmPLH. Key mechanisms-such as oxidative stress, DNA damage, pyroptosis, cGAS/STING pathway activation, and inhibition of cellular migration and invasion-were explored under varying treatment conditions in 4T1 cells. Tumor-bearing mice were employed to evaluate tumor-targeting capabilities and the synergistic tumor-suppressive effects of RmPLH combined with PD-1 inhibitors. Comprehensive safety evaluations, including blood tests, biochemical analyses, and histopathological examinations, were also conducted. Results: The synthesized Pt-CoNi LDH exhibited a uniform rhombic dodecahedral nanocage morphology with an average particle size of approximately 231 nm. Encapsulation with red blood cell membranes conferred prolonged systemic circulation, enhanced tumor targeting, and reduced immune clearance for RmPLH. Upon ultrasound (US) stimulation, the LDH released substantial levels of reactive oxygen species (ROS) and platinum ions. The ROS effectively induced endoplasmic reticulum stress and ferroptosis, while platinum ions facilitated DNA crosslinking, triggering significant DNA damage. ROS-induced pyroptosis released inflammatory mediators and damage-associated molecular patterns (DAMPs), which activated the cGAS/STING pathway and reinforced ICD. Combining RmPLH with PD-1 inhibitors significantly enhanced therapeutic efficacy against TNBC. Furthermore, safety assessments confirmed the excellent biocompatibility and biosafety of RmPLH. Conclusion: The integration of RmPLH with PD-1 inhibitors substantially amplifies ICD, fostering robust antigen-specific T cell immunity and offering a promising therapeutic strategy for TNBC. This study represents a pioneering application of Pt (II)-based LDH nanocages in oncology, laying a foundation for future innovations in tumor immunotherapy.

01 Jan 2025·The American Journal of Pathology

KMeansGraphMIL

Article

Author: Liu, Weixiang ; Xiao, Huiling ; Jiang, Jiale ; Huang, Wensheng ; Li, Bing ; Chen, Linghao

Colorectal cancer (CRC) is one of the top three most lethal malignancies worldwide, posing a significant threat to human health. Recently proposed immunotherapy checkpoint blockade treatments have proven effective for CRC, but their use depends on measuring specific biomarkers in patients. Among these biomarkers, Tumor Mutational Burden (TMB) has emerged as a novel indicator, traditionally requiring Next-Generation Sequencing (NGS) for measurement, which is time-consuming, labor-intensive, and costly. To provide an economical and rapid way to predict patients' TMB, we propose the KMeansGraphMIL model based on weakly supervised multiple-instance learning (WSMIL). Compared to previous WSMIL models, KMeansGraphMIL leverages both the similarity of image patch feature vectors and the spatial relationships between patches. This approach improves the model's AUC to 0.8334 and significantly increases the recall to 0.7556. Thus, we present an economical and rapid framework for predicting CRC TMB, offering the potential for doctors to quickly develop treatment plans and saving patients substantial time and money.

100 Deals associated with The 1St Affiliated Hosp of Guangdong Pharm University

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100 Translational Medicine associated with The 1St Affiliated Hosp of Guangdong Pharm University

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Pipeline

Pipeline Snapshot as of 23 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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