Danone Asia Pacific Holdings Pte Ltd.

Patient-reported outcome measures (PROMs) and patient registries both play important roles in assessing patient outcomes. However, no study has examined the use of PROMs among registries involving patients with type 2 diabetes mellitus (T2DM). Our objective is twofold: first, to review the range of PROMs used in registry-based studies of patients with T2DM; second, to describe associations between these PROMs, T2DM and its complications.

The International Consortium for Health Outcomes Measurement (ICHOM) Diabetes Standard Set recommended routine usage of PROMs to assess psychological well-being, diabetes distress, and depression among patients with T2DM. A wide variety of PROMs were used among the 15 studies included in this review. Quality of life, depressive symptoms and treatment adherence were the most common aspects of T2DM that utilised PROMs for assessment. Adoption of PROMs among registries of patients with T2DM remains uncommon, non-routine and with few that are validated before use.

A HPLC method was developed for determination of nucleotides in infant formula milk powder.The sample is precipitated by 13% perchloric acid and adjusted to pH 6.5-7.0.Nucleotides are detected by HPLC at 278 nm and 257 nm.The LOQ of the nucleotide was CMP of 1.6 mg/100 g, UMP of 1.7 mg/100 g, GMP of 1.8 mg/100 g, IMP of 1.0mg/100 g, AMP of 2.0 mg/100 g.The average recovery is in the range of 85-110%.

A direct test method for Cr(VI) determination in milk powder was developed.The method comprised the following steps: ashing sample at 550°C muffle, adding a complexing reagent thenoyltrifluoroacetone(TTA) and acetate acid-acetate ammonium buffer solution, then analyzing with GF-AAS after several hours.The Cr(III) in milk powder sample and TTA can form a complex Cr(TTA)3 which can volatile before atomization, so the remaining Cr(VI) can be determined directly.This method has good linearity within the concentration range 1 μg/L∼20 μg/L, and the correlation coefficient can reach 0.999.The recoveries exceed 75% when the spike concentration is no less than 50 μg/kg, and RSD is less then 12.6%.