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Overview

Phase 2a study to assess the safety and efficacy of IV infused spray-dried solvent/detergent -treated plasma (Resusix) when compared with an equal volume of plasma frozen within 24 hours after phlebotomy (FP24) in patients with liver disease who are actively bleeding or who require prophylaxis for surgical bleeding

Start Date14 Dec 2018

Sponsor / Collaborator

Entegrion, Inc.

NCT03679286 / Unknown statusNot Applicable

Comparative Analysis of the Entegrion Point of Care Coagulation Monitor (PCM) With ROTEM in the Measurement of Viscoelastic Coagulation Parameters

To determine if PMC viscoelastic coagulation parameters correlate with those generated by a marketed device in adult patients who require hemostasis monitoring or who are at risk of bleeding or thrombotic indications

Start Date20 Aug 2018

Sponsor / Collaborator

Entegrion, Inc.

NCT03133351 / Unknown statusNot Applicable

Reference Range Analysis of the Entegrion Point of Care Coagulation Monitor (PCM™) in Healthy Volunteers

This study is intended to define the PCM normal laboratory range.

Start Date04 Apr 2017

Sponsor / Collaborator

Entegrion, Inc.

100 Clinical Results associated with Entegrion, Inc.

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0 Patents (Medical) associated with Entegrion, Inc.

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Literatures (Medical) associated with Entegrion, Inc.

01 Apr 2016·TransfusionQ3 · MEDICINE

Dried plasma: state of the science and recent developments

Q3 · MEDICINE

Review

Author: Cap, Andrew P. ; Kozar, Rosemary A. ; Prat, Nicolas ; Schreiber, Martin A. ; Given, Michael B. ; Malloy, Wilbur W. ; Spinella, Philip C. ; Macdonald, Victor W. ; Pidcoke, Heather F. ; Pati, Shibani ; Dacorta, Joseph A. ; Sailliol, Anne ; Pusateri, Anthony E. ; Kupferer, Kevin R. ; Khan, Abdul

The early transfusion of plasma is important to ensure optimal survival of patients with traumatic hemorrhage. In military and remote or austere civilian settings, it may be impossible to move patients to hospital facilities within the first few hours of injury. A dried plasma product with reduced logistical requirements is needed to enable plasma transfusion where medically needed, instead of only where freezers and other equipment are available. First developed in the 1930s, pooled lyophilized plasma was widely used by British and American forces in WWII and the Korean War. Historical dried plasma products solved the logistical problem but were abandoned because of disease transmission. Modern methods to improve blood safety have made it possible to produce safe and effective dried plasma. Dried plasma products are available in France, Germany, South Africa, and a limited number of other countries. However, no product is available in the US. Promising products are in development that employ different methods of drying, pathogen reduction, pooling, packaging, and other approaches. Although challenges exist, the in vitro and in vivo data suggest that these products have great potential to be safe and effective. The history, state of the science, and recent developments in dried plasma are reviewed.

100 Deals associated with Entegrion, Inc.

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100 Translational Medicine associated with Entegrion, Inc.

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Pipeline

Pipeline Snapshot as of 30 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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