Article
Author: Zhang, Liting ; Long, Youming ; Zheng, Xiujun ; Chen, Hao ; Yu, Xinhua ; Qiu, Wei ; Yin, Junping ; Jiang, Ying ; Petersen, Frank ; Fu, Ying ; Zhou, Jing ; Ye, Jinlong ; Peng, Fuhua ; Xiao, Li ; Chen, Juanjuan ; Zhou, Qiaomiao ; Huang, Renliang ; Zhou, Juan ; Wang, Zhanhang ; Shu, Yaqing ; Li, Qihui ; Zhou, Yanxia ; Lan, Zhike ; Liu, Xu ; Li, Huilu ; Lu, Zhengqi ; Lu, Yi
We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA‐A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32–3.06, p = 0.00072, padj. = 0.046) and HLA‐DBP1*0501 (OR = 0.51, 95% CI = 0.36–0.71, p = 0.000048, padj. = 0.0062). Moreover, HLA‐A*3303 carriers with the disease had a longer hospital stay (p = 0.0005) than non‐carriers. This study for the first time provides evidence for a role of genetic factor in the development of autoimmune GFAP astrocytopathy. ANN NEUROL 2024;95:901–906