Shandong Tianda Biochemical Pharmaceutical Co. Ltd.

A single-center, randomized, open-label, two-period, self-crossover, single-dose design was used to evaluate the bioequivalence of clarithromycin granules (specification: 0.125 g) produced by Xinhua Pharmaceutical (Gaomi) Co., Ltd. and clarithromycin dry suspension (trade name: Klacid, specification: 125 mg/5 mL) certified by ABBVIE S.R.L. in healthy people when taken orally on an empty stomach or after a meal, and to evaluate the safety of clarithromycin granules (specification: 0.125 g) produced by Xinhua Pharmaceutical (Gaomi) Co., Ltd.

A single-center, randomized, open, two-period, self-crossover, single-dose design was used to compare the differences in absorption extent and rate of ibuprofen suspension (100 mL/2 g) produced by Shandong Yikang Pharmaceutical Co., Ltd. and ibuprofen suspension (trade name: Motrin®, specification: 100 mL/2 g) produced by Shanghai Johnson & Johnson Pharmaceuticals Co., Ltd. under fasting and postprandial administration conditions in healthy Chinese people, and to evaluate the safety of ibuprofen suspension produced by Xinhua Pharmaceutical (Gaomi) Co., Ltd.

(1) Through the bioequivalence study of diltiazem hydrochloride tablets administered on an empty stomach and after meals, the bioequivalence of diltiazem hydrochloride tablets produced by Xinhua Pharmaceutical (Gaomi) Co., Ltd. and diltiazem hydrochloride tablets produced by Tabe Mitsubishi Manufacturing Co., Ltd. was evaluated. Provide evidence for the consistent clinical efficacy of diltiazem hydrochloride tablets produced by Xinhua Pharmaceutical (Gaomi) Co., Ltd. and the original diltiazem hydrochloride tablets. (2) Evaluate the safety of diltiazem hydrochloride tablets.