Introduction: This study focuses on the treatment of painful crises in Sickle Cell Disease (SCD) patients using Paracoxib, a non-opioid, compared to Morphine. It addresses the need for alternative medications that reduce opioid dependency while providing effective analgesia.
Objectives:
Primary: Evaluate the analgesic effect of Paracoxib versus Morphine in SCD vaso-occlusive crises.
Secondary: Reduce opioid use/dependence, decrease the length of hospital stays, and monitor side effects related to Paracoxib.
Methodology: A double-blinded randomized controlled trial, conducted in a tertiary care emergency department. The study includes adult SCD patients with moderate to severe crises, excluding non-VOC pain, certain medications, and specific medical conditions. The sample size is 226 patients, split equally into two groups.
Intervention: Patients receive either Morphine or Paracoxib, with periodic assessment of vital signs and pain. Additional Morphine is administered if required. Data collection and analysis are meticulously planned.
Expected Outcomes: Improvement in SCD pain management, reduction in opioid usage, and potential benefits in terms of hospital stays and patient satisfaction.

Start Date01 May 2026

Sponsor / Collaborator

Armed Forces Hospital

NCT06522581

/ RecruitingPhase 1IIT

Role of Citicoline in Treatment of Neonates With Hypoxic Ischemic Encephalopathy

Hypoxic ischemic encephalopathy is an acute or subacute brain injury, due to asphyxia in neonates, leading to mortality and long-term morbidity. Its prevalence varies across regions, with developed countries reporting rates of 1.5 per 1000 live births, while developing nations experience a wider range from 2.3 to 26.5 per 1000 live births.
Infants afflicted with moderate HIE face a 10% risk of mortality, with surviving individuals encountering a 30% chance of developing disabilities. The prognosis is graver for severe HIE, with a mortality risk of 60%, and nearly all survivors experiencing some form of disability.

Start Date01 Jan 2024

Sponsor / Collaborator

Armed Forces Hospital

NCT05823649

/ Not yet recruitingNot ApplicableIIT

Effect of Early Versus Delayed Postoperative Feeding in Lower Limb Fracture Surgery: a Randomized Controlled Trial

The treatment of lower limb fracture accounting one third of total fracture is a complex problem for the surgical and rehabilitation team. Patients are kept in long term fasting after surgery to prevent from postoperative complications, but it leads to the surgical catabolism resulting delaying the desired improvement in patients. To our knowledge, it has not been widely implemented in clinical settings. Therefore, the aim of the study is to evaluate the effect of early versus delayed postoperative oral feeding in lower limb fracture surgery under regional block anesthesia.
This study utilize single-center, hospital based, open-label, parallel group randomized controlled trial to assess the effect of early postoperative oral feeding in two hours after the surgery over the conventionally delayed feeding. A representative sample size of 275 patients (control group=138 and study group =137) aged 18 years and above having lower limb fracture operated under regional block will be selected for research. The pre-operative nutritional status will be identified with Simplified Nutritional Appetite Questionnaire (SNAQ) and the post-operative outcomes will be measured by Numerical Rating Scale (NRS) system. Preoperative as well as postoperative hand grip strength and Neutrophil Lymphocyte Ratio (NLR) will be assessed. Statistical analysis will be performed using chi square test, Student two sample t-test to compare between the outcome of study and control groups. The outcome of the study may provide an empirical evidence to the anesthesiologists and surgeons towards the emerging concept of postoperative early oral feeding practice in lower limb fracture surgery in clinical settings.

Start Date20 Apr 2023

Sponsor / Collaborator

Armed Forces Hospital

100 Clinical Results associated with Armed Forces Hospital

0 Patents (Medical) associated with Armed Forces Hospital

1,007

Literatures (Medical) associated with Armed Forces Hospital

01 May 2025·Journal of Infection and Public Health

Comprehensive field investigation of a large botulism outbreak, Saudi Arabia, 2024

Article

Author: Saqah, Rayyan Mohammad ; Alrougi, Hamoud Marzouq ; Almutairi, Abdulaziz Saad ; Deeb, Mohammad Al ; Kamel, Shady Abdelrahman ; Alfaifi, Musa ; Abd-Ellatif, Eman Elsayed ; Alyahya, Bader ; AlAsseri, Yahya Abdullah ; Zuayr, Saad Nasser Al ; Albogami, Hussein Ayaed ; Alahmad, Abdulmohsen Mohammed ; Almutairi, Abd Elelah Hamoud

BACKGROUNDBotulism is an uncommon and possibly lethal disease caused by botulinum neurotoxins, produced by Clostridium botulinum, Clostridium butyricum, and Clostridium baratii. Food-borne botulism typically results from consuming homemade canned, preserved, or fermented food. This paper presents the first documented occurrence of a commercially prepared food-borne botulism outbreak in Saudi Arabia.METHODSWe used information from medical charts to describe the outbreak by time, place and affected persons. Individuals who consumed food from a specific restaurant chain in Riyadh within one week of its closure and experienced symptoms compatible with botulism were included. One hundred and two cases were interviewed. All clinical data, laboratory investigations, and information regarding antitoxin administration were obtained. We reviewed the results of samples collected from food handlers and the environment. The public health actions and the outbreak source investigations were detailed.RESULTSA total of 50 cases have met the criteria for clinically confirmed botulism. Laboratory testing verified 10 (20 %) of the confirmed cases. Half of the cases were males with a mean age of 25.08 ( ± 6.42) and the other half were females with a mean age of 25.28 ( ± 9.38). Saudi nationals represented 90 % of cases. All cases reported eating from different branches of the same restaurant in Riyadh. The mean incubation period ranged from 4 to 101 h. Prevalent symptoms were dysphagia (80 %), dysarthria (78 %), peripheral muscle weakness (78 %), and diplopia (62 %). 96 % of cases received Antitoxin. Consumed food items included meat burgers (58 %), chicken burgers (22 %), fries (52 %), fries with meat (10 %), and sauces (100 %). BoNT types A and B were detected in one sample from a mayonnaise jar.CONCLUSIONThe study outlined an outbreak of food-borne botulism associated with commercially processed items. The early administration of antitoxins, high index of suspicion, and effective source control considerably reduced morbidity and mortality. It is uncommon for mayonnaise to cause botulism, so further testing is necessary to confirm this relationship. We recommend higher measures of monitoring and improving the food sector's preservation, storage, and quality control.

01 Apr 2025·Transplantation Proceedings

Do We Need a Predischarge Psychosocial Evaluation? A Case Report on Peri-Allograft Abscess in a Noncompliant Elderly Kidney Transplant Patient

Article

Author: Safar, Omar ; El Hennawy, Hany ; Ghalyoob, Tayseer ; Zaitoun, Mohammad F ; Qarni, Manea Al ; Khattab, Ahmed ; Bazeed, Mohamed F ; Atta, Eisa Al ; Awadh, Amal ; Faifi, Abdullah S Al

Although postrenal transplant surgical site infections are relatively uncommon, we present the case of a 72-year-old diabetic and hypertensive male patient who developed a delayed peri-graft abscess and severe surgical site infection due to a closed drain exit site infection 1 month following a living-related kidney transplant. While the transplant itself was successful and the patient had passed the pretransplant psychosocial evaluation, their post-transplant noncompliance and unresolved social barriers-such as missed outpatient follow-up appointments-significantly contributed to these complications. This case highlights the limitations of relying solely on pretransplant evaluations and, therefore, emphasizes the critical need for a comprehensive predischarge psychosocial assessment. Such an assessment is particularly vital, especially in elderly patients, as it helps identify and address risks for noncompliance and barriers to follow-up care. To address these challenges, we propose implementing a predischarge psychosocial scoring system that evaluates psychological well-being, social support, cognitive function, understanding of the care plan, and potential obstacles. By identifying high-risk patients, this tool can, in turn, guide tailored interventions to improve adherence. Consequently, a structured predischarge assessment system becomes essential for optimizing post-transplant care, enhancing outcomes, and reducing complications.

01 Apr 2025·European Journal of Heart Failure

Clinical management and therapeutic optimization of patients with heart failure with reduced ejection fraction and low blood pressure. A clinical consensus statement of the Heart Failure Association (HFA) of the ESC

Article

Author: Rosano, Giuseppe M.C. ; Bozkurt, Biykem ; Moura, Brenda ; Girerd, Nicolas ; Petrie, Mark C. ; Amir, Offer ; Chioncel, Ovidiu ; Merino, Jose L. ; Monzo, Luca ; Adamo, Marianna ; Mullens, Wilfried ; Ponikowski, Piotr ; Bayes‐Genis, Antoni ; Mebazaa, Alexandre ; Seferovic, Petar ; Metra, Marco ; Butler, Javed ; Böhm, Michael ; Savarese, Gianluigi ; Yilmaz, Mehmet Birhan ; Skouri, Hadi

Despite major advancements in heart failure (HF) management and guideline recommendations over the past two decades, real‐world evidence highlights suboptimal implementation of guideline‐directed medical therapy (GDMT) for HF with reduced ejection fraction (HFrEF). Low blood pressure (BP) is common in HFrEF patients and represents a major perceived barrier to implementing life‐saving treatments in clinical practice, as physicians are often concerned about symptomatic hypotension and its consequences. Although low BP can be seen in those hospitalized with signs of shock, the most common scenario involves non‐severe, asymptomatic hypotension in patients receiving foundational therapy for HFrEF, where premature down‐titration or discontinuation of GDMT should be avoided. This clinical consensus statement provides a comprehensive overview of low BP in HFrEF, including its definition, risk factors, and effects of HF therapies on BP. We propose management pathways to optimize HFrEF treatment in the context of low BP, ultimately aiming to improve patient outcomes.

News (Medical) associated with Armed Forces Hospital

18 May 2023

·www.mobihealthnews.com

Lunit expands AI deployment in military facilities overseas

Lunit is expanding its deployment of an AI imaging solution to South Korean military facilities and troops overseas. This comes following the successful pilot deployment of Lunit INSIGHT CXR, its AI-powered chest x-ray analysis software, last year in the army, navy, and air force medical institutions, including the Armed Forces Medical Command and the Armed Forces Capital Hospital. The company has been supplying its chest x-ray analysis solution to military-run medical facilities as part of the AI Convergence project of the South Korean Ministry of Science and ICT and the National IT Industry Promotion Agency. WHY IT MATTERS In the fourth year of its participation in the project, Lunit is helping further improve access to diagnostic and treatment services in remote areas where military troops are stationed, such as navy ships. Particularly, it plans to develop a customised AI solution that will be linked with portable x-ray imaging equipment to greatly increase care accessibility. THE LARGER TREND Lunit has been participating in the South Korean government's AI Convergence project since 2020 through its consortium with biotech company Basgen Bio. Aside from military facilities, Lunit INSIGHT CXR has also been deployed globally over the past few months. Lunit recently secured partnerships with the Albert Einstein Israelita Hospital in Brazil and with Radlink in Singapore to enhance their chest x-ray analysis capabilities using AI. Early this year, Lunit disclosed its plan to open a wholly-owned subsidiary in Europe to assist with its sales and network expansion.

08 Jun 2021

·www.globenewswire.com

Armed Forces Entertainment Brings Big Name Talent to Three

Joint Base Andrews, MD, June 08, 2021 (GLOBE NEWSWIRE) -- Armed Forces Entertainment (AFE) has an amazing lineup of Country musical talent for their upcoming summer concert series, Heat Wave. Three virtual concerts will stream free across AFE’s website, YouTube, and Facebook Watch beginning June 15, allowing military personnel and their families around the world to enjoy top-tier performances on their own schedules in their respective time zones. Created exclusively by AFE for military audiences, the 2021 Heat Wave series features top Country artists up close and personal. On June 15, singer-songwriter Rodney Atkins is joined by fellow singer-songwriters Lee Brice, Josh Turner and Jennifer Smestad, plus American Idol winner Scotty McCreery and hit vocal band Parmalee. The June 25 show features the silky voice of Brian McKnight, who rose to fame with hit song and album Anytime, which went double platinum in 1997. Then he exceeded his own success with the triple-platinum album/single Back at One in 1999 on the Motown Records label. Soulful and deep, the song resonated with country artist Mark Wills who covered it that same year. The final show in the Heat Wave series will be released June 29, just in time for Independence Day. The Grand Ole Opry Salutes America’s Heroes show, features a sparkling lineup of popular artists including the powerhouse band Lady A, multi-platinum award-winner Luke Combs, legendary country star Lee Greenwood, singer-songwriter Carly Pearce, American Idol star Lauren Alaina and Nashville Star winner Chris Young. The musicians have prepared special sets to perform for this unique audience of dedicated Americans deployed or stationed overseas. “This exciting lineup of popular American musical artists starts the summer off with upbeat music and a heartfelt message of gratitude to our military members across the globe,” said Brian Burke, AFE Marketing & Business Analyst. The full artist lineup and schedule is available at the Heat Wave hub. About Armed Forces Entertainment: Armed Forces Entertainment (AFE) is the official agency of the Department of Defense providing quality entertainment to U.S. military personnel serving overseas, primarily at contingency operations and in remote and isolated locations. Now in its 70th year, AFE brings a touch of home through music, sports and comedy entertainment to more than 400,000 troops annually, providing our dedicated military members much-needed downtime. For more information, schedules, and downloadable images, visit: , Facebook, Instagram, Twitter or YouTube Attachments

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