Chong Qing Jun Yao Sheng Wu Yi Yao You Xian Gong Si

Main study objectives: This study aims to study the pharmacokinetic characteristics of loxoprofen sodium patch (100 mg/patch (10 cm×14 cm)) produced by Nanjing Jiuxiao Pharmaceutical Co., Ltd. in healthy subjects after single fasting use; loxoprofen sodium patch (Lesong®, 100 mg/patch (10 cm×14 cm)) certified by LEAD CHEMICAL CO., LTD. was used as the reference preparation to compare the pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞ of the two preparations and evaluate the bioequivalence of the two preparations in humans. Secondary study objectives: 1) Evaluate the safety of the test preparation and the reference preparation in healthy subjects; 2) Evaluate the adhesion and skin irritation of the test preparation and the reference preparation during medication in healthy subjects.

The main purpose of the study is to investigate the pharmacokinetic characteristics of the test preparation cefditoren pivoxil granules and the reference preparation cefditoren pivoxil granules in Chinese healthy adult subjects after a single oral administration under fasting and fed conditions, and to evaluate the bioequivalence of the two preparations after oral administration under fasting and fed conditions. Secondary purpose of the study is to evaluate the safety of the test preparation and the reference preparation in Chinese healthy adult subjects.