Jiangsu Wanchuan Medical & Health Industry Group Co., Ltd.

Main research purposes: This study investigated the single oral administration of fludrocortisone acetate tablets (test preparation, specification: 0.1 mg) provided by Jiangsu Fuzinyu Pharmaceutical Technology Co., Ltd. or Fluoroacetate produced by Aspenjiban Co., Ltd. under fasting and postprandial conditions. Pharmacokinetic characteristics of hydrocortisone tablets (reference preparation, trade name: Florinef®, strength: 0.1 mg), evaluation of bioequivalence between the two preparations. Secondary research purposes: Observe that a single oral dose of 0.1 mg of the test preparation fludrocortisone acetate tablet (specification: 0.1 mg) or the reference preparation fludrocortisone acetate tablet (trade name: Florinef®, specification: 0.1 mg) in healthy subjects security in the user.

MAIN STUDY OBJECTIVE: To evaluate the rate and extent of absorption of fludrocortisone acetate tablets and FLORINEF® in healthy male and female subjects under postprandial conditions, and to evaluate whether there is bioequivalence between the two formulations. Secondary study objectives: To evaluate the safety of the test preparation fludrocortisone acetate tablets and the reference preparation FLORINEF® in healthy Chinese subjects.

MAIN STUDY OBJECTIVE: To evaluate the rate and extent of absorption of fludrocortisone acetate tablets and FLORINEF® in healthy male and female subjects on an empty stomach, and to evaluate whether there is bioequivalence between the two preparations. Secondary study objectives: To evaluate the safety of the test preparation fludrocortisone acetate tablets and the reference preparation FLORINEF® in healthy Chinese subjects.