Basilea Pharmaceutica AG

Durable royalties portfolio generated $58.4 million in revenue for the fourth quarter and $250.3 million for the full year IST achieved U.S. net product sales of $33.9 million for the fourth quarter and $119.2 million for the full year, representing 47% year-over-year growth IST product portfolio strengthened with U.S. FDA approval of NUZOLVENCE ® , a first-in-class treatment for uncomplicated urogenital gonorrhea $125 million share repurchase program initiated in the fourth quarter BURLINGAME, Calif.--(BUSINESS WIRE)--Innoviva, Inc. (NASDAQ: INVA) (“Innoviva” or the “Company”), a diversified biopharmaceutical company with a core royalties portfolio, a leading critical care and infectious disease platform known as Innoviva Specialty Therapeutics (“IST”), and a portfolio of strategic investments in healthcare assets, today reported financial results for the fourth quarter and full year ended December 31, 2025, and highlighted select corporate progress and achievements. “2025 marked an excellent year for Innoviva, demonstrating strength across all areas of our business, with 15% revenue growth to over $400 million and net income exceeding $270 million. Our royalty business continued to provide stable and resilient cash flow, while IST generated 47% year-over-year U.S. sales growth to $119 million,” said Pavel Raifeld, Chief Executive Officer of Innoviva. “We expanded our commercial portfolio with the successful mid-2025 launch of ZEVTERA in the U.S., received nominations for two of our products for the prestigious 2025 Prix Galien USA Award, and ended the year on an exciting note with the FDA approval of our fifth product, NUZOLVENCE, a single-dose oral treatment for uncomplicated urogenital gonorrhea that addresses a critical public health challenge in light of the global rise of gonococcal drug resistance. We are excited about our growth prospects and anticipate $150 million or more in IST U.S. net product sales in 2026.” “Our portfolio of strategic assets remains a key platform for long-term growth and differentiation, demonstrated by significant advances and value creation at Armata Pharmaceuticals. Overall, we remain a well-capitalized company with multiple value-accretive capital deployment opportunities in our current business, novel assets, and capital strategies, including a recently announced $125 million share repurchase program. We look forward to multiple inflection points across Innoviva’s portfolio in the year ahead,” concluded Mr. Raifeld. Financial Highlights Total revenue: Total revenue for the fourth quarter 2025 was $114.6 million, representing 25% growth compared to total revenue of $91.8 million for the fourth quarter 2024. Total revenue for the full year 2025 was $411.3 million, reflecting 15% growth compared to total revenue of $358.7 million for the full year 2024. Royalty revenue: Fourth quarter 2025 gross royalty revenue from Glaxo Group Limited (“GSK”) was $58.4 million and full year was $250.3 million, compared to $66.0 million for the fourth quarter 2024 and $255.6 million for the full year 2024. Net product sales: Fourth quarter 2025 net product sales were $59.1 million, more than doubling from $28.9 million in the same quarter of 2024. Full year 2025 net product sales were $172.1 million, an increase of 77% compared to $97.5 million for the full year 2024. For the fourth quarter 2025, U.S. net product sales were $33.9 million and ex-U.S. net product sales were $25.1 million. Fourth quarter 2025 U.S. net product sales primarily consisted of $19.3 million from GIAPREZA ® , $10.7 million from XACDURO ® , and $3.8 million from XERAVA ® . For the full year 2025, U.S. net product sales were $119.2 million and ex-U.S. net product sales were $52.9 million. Full year 2025 U.S. net product sales primarily consisted of $71.8 million from GIAPREZA ® , $33.4 million from XACDURO ® , and $13.3 million from XERAVA ® . Income from operations: Fourth quarter 2025 income from operations was $39.0 million, compared to $43.1 million for the fourth quarter 2024. Full year 2025 income from operations was $163.7 million, compared to $166.9 million for the full year 2024, reflecting continued investments in research and development. Equity and long-term investments: Fourth quarter and full year 2025 net favorable changes in fair values of equity and long-term investments totaled $153.8 million and $161.6 million, respectively, and were primarily attributable to share price appreciation of Armata Pharmaceuticals. Innoviva’s portfolio of strategic assets held through the Company’s various subsidiaries was valued at $614.0 million as of December 31, 2025, and consisted of $397.9 million in Armata Pharmaceuticals investments, $136.4 million in other strategic equity and convertible debt investments, and $79.7 million in investments held by ISP Fund. Net income: Fourth quarter 2025 net income of $164.2 million ($2.19 basic earnings per share) and full year 2025 net income of $271.2 million ($4.02 basic earnings per share) were driven primarily by higher revenue and the positive impact of changes in the fair values of equity and long-term investments. Cash and cash equivalents: Totaled $550.9 million. Royalty and net product sales receivables totaled $93.3 million as of December 31, 2025. Key Business and R&D Highlights NUZOLVENCE ® (zoliflodacin): a first-in-class, single-dose oral medication for the treatment of uncomplicated urogenital gonorrhea due to Neisseria gonorrhoeae in adults and pediatric patients 12 years and older weighing at least 35kg, developed in partnership with The Global Antibiotic Research & Development Partnership ("GARDP"). In December 2025, IST received U.S. Food and Drug Administration (FDA) approval of NUZOLVENCE ® for the treatment of uncomplicated urogenital gonorrhea. FDA approval was based on results from the largest Phase 3 clinical trial ever conducted for a new treatment against Neisseria gonorrhoeae infection in regions with a high prevalence of gonorrhea across five countries. Additionally, in December 2025, the positive NUZOLVENCE ® Phase 3 data for the treatment of uncomplicated urogenital gonorrhea were published in The Lancet . The Company plans to commercialize NUZOLVENCE ® in the second half of 2026, either in collaboration with a commercialization partner or independently. In October 2025, IST delivered data from six presentations at IDWeek 2025, including clinical data, pharmacokinetic/pharmacodynamic analyses, and microbiologic surveillance from its growing portfolio of antibiotics and critical care medicines. Both ZEVTERA ® (ceftobiprole medocaril sodium) and XACDURO ® (sulbactam for injection; durlobactam for injection) were nominated for the 2025 Prix Galien USA Award for Best Pharmaceutical Product by the Galien Foundation, one of the most prestigious honors in the biopharmaceutical and medical technology fields, celebrating groundbreaking achievements that drive meaningful progress. Capital Allocation Since the inception of the share repurchase program, the Company has repurchased 797,298 shares for $16.0 million. In October 2025, Innoviva invested $17.5 million in the Series B Preferred Stock of Beacon Biosignals, Inc., an AI-driven neurotechnology company developing treatments for neurological, psychiatric, and sleep disorders. About Innoviva Innoviva is a diversified biopharmaceutical company with a core royalties portfolio, a leading critical care and infectious disease platform known as Innoviva Specialty Therapeutics (“IST”), and a portfolio of strategic investments in healthcare assets. Innoviva’s royalty portfolio includes respiratory assets partnered with Glaxo Group Limited (“GSK”). Innoviva is entitled to receive royalties from GSK on sales of RELVAR ® /BREO ® ELLIPTA ® and ANORO ® ELLIPTA ® . Innoviva’s critical care and infectious disease assets under the IST platform include GIAPREZA ® (angiotensin II) for increasing blood pressure in adults with septic or other distributive shock, XACDURO ® (sulbactam for injection; durlobactam for injection), co-packaged for intravenous use for the treatment of adults with hospital-acquired and ventilator-associated bacterial pneumonia caused by susceptible strains of Acinetobacter baumannii-calcoaceticus , XERAVA ® (eravacycline) for the treatment of complicated intra-abdominal infections in adults, ZEVTERA (ceftobiprole), an advanced-generation cephalosporin antibiotic licensed from Basilea Pharmaceutica International Ltd, Allschwil, and NUZOLVENCE® (zoliflodacin), approved by the FDA for the oral treatment of uncomplicated urogenital gonorrhea in adults and pediatric patients 12 years of age and older weighing at least 35 kg. For more information about Innoviva, go to . For information about Innoviva Specialty Therapeutics, go to . ANORO ® , RELVAR ® and BREO ® are trademarks of the GSK group of companies. ZEVTERA is a trademark of Basilea Pharmaceutica Ltd, Allschwil. Forward Looking Statements This press release contains certain “forward-looking” statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans, objectives, and future events. Innoviva intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. The words “anticipate”, “expect”, “goal”, “intend”, “objective”, “opportunity”, “plan”, “potential”, “target” and similar expressions are intended to identify such forward-looking statements. Such forward-looking statements involve substantial risks, uncertainties, and assumptions. These statements are based on the current estimates and assumptions of the management of Innoviva as of the date of this press release and are subject to known and unknown risks, uncertainties, changes in circumstances, assumptions and other factors that may cause the actual results of Innoviva to be materially different from those reflected in the forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, risks related to: expected cost savings; lower than expected future royalty revenue from respiratory products partnered with GSK; the commercialization of RELVAR ® /BREO ® ELLIPTA ® , ANORO ® ELLIPTA ® , GIAPREZA ® , XERAVA ® , XACDURO ® , ZEVTERA ® and NUZOLVENCE ® in the jurisdictions in which these products have been approved; the strategies, plans and objectives of Innoviva (including Innoviva’s growth strategy and corporate development initiatives); the timing, manner, and amount of potential capital returns to shareholders; the status and timing of clinical studies, data analysis and communication of results; the potential benefits and mechanisms of action of product candidates; expectations for product candidates through development and commercialization; the timing of regulatory approval of product candidates; and projections of revenue, expenses and other financial items; the timing, manner and amount of capital deployment, including potential capital returns to stockholders; and risks related to the Company’s growth strategy. Other risks affecting Innoviva are described under the headings “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” contained in Innoviva’s Annual Report on Form 10-K for the year ended December 31, 2025 and Quarterly Reports on Form 10-Q, which are on the Securities and Exchange Commission (“SEC”) and available on the SEC’s website at . Past performance is not necessarily indicative of future results. No forward-looking statements can be guaranteed, and actual results may differ materially from such statements. Given these uncertainties, you should not place undue reliance on these forward-looking statements. The information in this press release is provided only as of the date hereof, and Innoviva assumes no obligation to update its forward-looking statements on account of new information, future events or otherwise, except as required by law. INNOVIVA, INC. Condensed Consolidated Statements of Income (in thousands, except per share data) (Unaudited) Three Months Ended Year Ended December 31, December 31, 2025 2024 2025 2024 Revenue: Royalty revenue, net (1) $ 54,896 $ 62,520 $ 236,479 $ 241,733 Net product sales 59,064 28,935 172,130 97,492 License and other revenue 653 351 2,719 19,486 Total revenue 114,613 91,806 411,328 358,711 Cost of products sold (inclusive of amortization of inventory fair value adjustments) 32,309 7,165 77,384 36,598 Amortization of acquired intangible assets 6,637 6,511 26,277 25,902 Gross profit 75,667 78,130 307,667 296,211 Operating expenses: Selling, general and administrative 32,124 31,326 113,318 115,690 Research and development 4,555 3,665 30,604 13,654 Total operating expenses 36,679 34,991 143,922 129,344 Income from operations 38,988 43,139 163,745 166,867 Changes in fair values of equity method investments, net 111,149 (21,256 ) 141,433 (64,253 ) Changes in fair values of equity and long-term investments, net 42,669 1,666 20,160 (59,161 ) Interest and dividend income 6,151 5,768 21,086 19,141 Interest expense (3,309 ) (4,749 ) (16,698 ) (22,209 ) Other expense, net (612 ) 126 (2,864 ) (2,997 ) Income before income taxes 195,036 24,694 326,862 37,388 Income tax expense (30,883 ) (4,362 ) (55,697 ) (13,996 ) Net income $ 164,153 $ 20,332 $ 271,165 $ 23,392 Net income per share: Basic $ 2.19 $ 0.32 $ 4.02 $ 0.37 Diluted $ 1.94 $ 0.26 $ 3.30 $ 0.36 Shares used to compute net income per share: Basic 74,796 62,626 67,395 62,726 Diluted 85,264 84,200 84,760 74,187 (1) Total net revenue is comprised of the following (in thousands): Three Months Ended Year Ended December 31, December 31, 2025 2024 2025 2024 (unaudited) (unaudited) Royalties $ 58,351 $ 65,975 $ 250,302 $ 255,556 Amortization of capitalized fees (3,455 ) (3,455 ) (13,823 ) (13,823 ) Royalty revenue, net $ 54,896 $ 62,520 $ 236,479 $ 241,733 INNOVIVA, INC. Condensed Consolidated Balance Sheets (in thousands) (unaudited) December 31 2025 2024 Assets Cash and cash equivalents $ 550,941 $ 304,964 Royalty and product sale receivables 93,317 86,366 Inventory 39,172 33,725 Prepaid expense and other current assets 28,358 21,719 Current portion of ISP Fund investments 15,727 107,532 Property and equipment, net 1,555 514 Equity method and equity and long-term investments 598,223 393,957 Capitalized fees 56,138 69,961 Right-of-use assets 10,929 2,453 Goodwill 17,905 17,905 Intangible assets 182,156 208,433 Deferred tax assets, net — 12,054 Other assets 40,744 41,477 Total assets $ 1,635,165 $ 1,301,060 Liabilities and stockholders’ equity Other current liabilities $ 43,808 $ 39,507 Accrued interest payable 1,618 3,422 Deferred revenue 4,270 1,126 Convertible senior notes, due 2025, net — 192,028 Convertible senior notes, due 2028, net 257,731 256,316 Deferred tax liabilities, net 31,793 — Income tax payable, long term 57,013 53,227 Other long term liabilities 66,091 64,275 Stockholders’ equity 1,172,841 691,159 Total liabilities and stockholders’ equity $ 1,635,165 $ 1,301,060 INNOVIVA, INC. Cash Flows Summary (in thousands) (unaudited) Year Ended December 31, 2025 2024 Net cash provided by operating activities $ 196,930 $ 188,690 Net cash provided by (used in) investing activities 40,496 (63,786 ) Net cash provided by (used in) financing activities 8,551 (13,453 ) Net change $ 245,977 $ 111,451 Cash and cash equivalents at beginning of period 304,964 193,513 Cash and cash equivalents at end of period $ 550,941 $ 304,964 Contacts Investor Relations (Internal): Eleanor Barisser Director, Investor Relations and Corporate Communications Eleanor.barisser@inva.com Investors and Media: Argot Partners (212) 600-1902 innoviva@argotpartners.com

February 25, 2026 Basilea Pharmaceutica Ltd, Allschwil (SIX: BSLN), a commercial-stage biopharmaceutical company committed to meeting the needs of patients with severe bacterial and fungal infections, announced today that the Biomedical Advanced Research and Development Authority (BARDA), part of the Administration for Strategic Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services, awarded USD 6 million to Basilea to continue the development of Basilea’s novel oral antibiotic ceftibuten-ledaborbactam etzadroxil, a beta-lactam/beta-lactamase inhibitor (BL/BLI) combination, for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis. David Veitch, Chief Executive Officer of Basilea, said: “We are very pleased to receive the continued funding from BARDA to support the further development of our novel antibiotic ceftibuten-ledaborbactam, including the preparation of clinical phase 3 studies. We believe that, by addressing the critical unmet medical need for the oral treatment of cUTIs caused by multidrug-resistant bacteria, this candidate holds a strong promise for patients suffering from these severe infections.” Under the terms of the specific Contract[1] with BARDA, upon completion of predefined milestones, Basilea could be reimbursed for a significant proportion of the further development costs required to bring the candidate to market, including the planned phase 3 clinical studies. After the current tranche of USD 6 million, the Contract could provide up to USD 147 million of additional non-dilutive funding. About beta-lactam/beta-lactamase inhibitor (BL/BLI) combinations Many Gram-negative bacteria express enzymes such as extended spectrum beta-lactamases (ESBL) that confer resistance against commonly used antibiotics. Beta-lactamase inhibitors block these enzymes and restore the activity of beta-lactam antibiotics against initially resistant Gram-negative bacteria, therefore BL/BLI combinations are an important addition to the armamentarium for the treatment of infections caused by multidrug-resistant bacterial pathogens. Ledaborbactam etzadroxil is the orally bioavailable prodrug of ledaborbactam, a novel broad-spectrum boronic acid beta-lactamase inhibitor, which is being developed in combination with ceftibuten, an oral cephalosporin antibiotic, which is approved in the US for the treatment of upper and lower respiratory tract infections and for urinary tract infections outside the US. In vitro and in vivo studies demonstrated that ledaborbactam etzadroxil restores the activity of ceftibuten against strains of Enterobacterales expressing Ambler class A extended spectrum beta-lactamases (ESBLs), class C cephalosporinases, and class A and D carbapenemases (KPC and OXA-48, respectively) as well as multidrug-resistant (MDR) Enterobacterales.[2] Ceftibuten-ledaborbactam etzadroxil has been granted Qualified Infectious Disease Product (QIDP) and Fast Track designations by the US Food and Drug Administration (FDA) for cUTI and uncomplicated urinary tract infections. Ceftibuten-ledaborbactam etzadroxil is an investigational drug and is not yet approved in any country for commercial use. Complicated UTIs, which include pyelonephritis (kidney infections), are defined as urinary tract infections ascending from the bladder accompanied by local and systemic signs and symptoms and are one of the most common bacterial infections in hospital and community settings. Increasing resistance of bacteria causing complicated urinary tract infections has led to limited availability of effective oral antibiotic treatment options.[3] Currently, there are no approved oral beta-lactam or beta-lactam/beta-lactamase inhibitor combinations that are effective against Enterobacterales expressing Ambler class A ESBLs, class C cephalosporinases, and class A & D serine carbapenemases (KPC and OXA-48). Basilea is a commercial-stage biopharmaceutical company founded in 2000 and headquartered in Switzerland. We are committed to discovering, developing and commercializing innovative drugs to meet the needs of patients with severe bacterial and fungal infections. We have successfully launched two hospital brands, Cresemba for the treatment of invasive fungal infections and Zevtera for the treatment of bacterial infections. In addition, we have preclinical and clinical anti-infective assets in our portfolio. Basilea is listed on the SIX Swiss Exchange (SIX: BSLN). References This project has been funded in part with federal funds from the U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority, under Contract No. 75A50123C00050. J. A. Karlowsky, M. G. Wise, M. A. Hackel et al. Ceftibuten-Ledaborbactam Activity against Multidrug-Resistant and Extended-Spectrum-β-Lactamase-Positive Clinical Isolates of Enterobacterales from a 2018–2020 Global Surveillance Collection. Antimicrobial Agents and Chemotherapy 2022, Nov 15;66(11):e0093422 T. P. Lodise, T. Chopra, B. H. Nathanson et al. Epidemiology of Complicated Urinary Tract Infections due to Enterobacterales Among Adult Patients Presenting in Emergency Departments Across the United States. Open Forum Infectious Diseases 2022, Jun 24;9(7):ofac315. The content above comes from the network. if any infringement, please contact us to modify.

15% royalty income increase 11% total revenue increase Tripled net cash position Phase 3 program with fosmanogepix progressing as planned Financial guidance FY 2026: Double-digit increase in total revenue and operating profit Conference call and webcast today at 4 p.m. (CET) Ad hoc announcement pursuant to Art. 53 LR Allschwil, Switzerland, February 17, 2026 Basilea Pharmaceutica Ltd, Allschwil (SIX: BSLN), a commercial-stage biopharma company committed to meeting the needs of patients with severe bacterial and fungal infections, announced today its results for the financial year ended December 31, 2025. David Veitch, Chief Executive Officer, stated: “A few years ago, we set out to transform Basilea by focusing on treatments for severe bacterial and fungal infections. Since then, Basilea has become a profitable company, with consistent double-digit growth of in-market sales and an industry-leading R&D pipeline in our focus area. This progress reflects our clear strategy, strong execution, and commitment to addressing unmet medical needs for the benefit of patients.” He continued: “Today, Basilea is well positioned for its next phase of growth. Cresemba is the global leader for the treatment of invasive fungal infections, Zevtera is now commercially available in the US, and the phase 3 studies of fosmanogepix, our most advanced clinical stage compound, are progressing as planned toward a data readout in early 2028. We are preparing the start of the phase 3 program for our newly in‑licensed oral antibiotic, ceftibuten-ledaborbactam, whilst also advancing our earlier pipeline programs. Our goal is to have four commercial assets by 2030 and a broad R&D pipeline, in order to drive long-term growth.” Adesh Kaul, Chief Financial Officer, said: “In 2025, we delivered once again a strong financial performance, in a volatile business environment. Our robust commercial business and the significant increase in total revenue provided us with the financial strength to invest in both progressing fosmanogepix through phase 3 development and to also seize external growth opportunities, as shown by the in-licensing of ceftibuten-ledaborbactam. At the same time, we also strengthened our balance sheet in 2025 by reducing the nominal value of our outstanding convertible bonds by approximately 22% to CHF 76 million while also increasing our cash position to CHF 162 million.” He added: “We are preparing now for our next growth phase. In the next five-year period, we expect to generate around CHF 600 million in cumulative positive cash flows from our current commercial products, Cresemba and Zevtera. Together with our current strong cash balance, we have the financial strength to bring fosmanogepix and ceftibuten-ledaborbactam to the market, progress our earlier R&D portfolio and also seize external growth opportunities to ensure mid-term and long-term growth beyond our existing portfolio.” Financial summary In 2025, Basilea recognized total revenue of CHF 232.4 million (FY 2024: CHF 208.5 million), an increase of 11.4% year-on-year. Royalty income rose to CHF 111.6 million (FY 2024: CHF 96.7 million), up 15.4% year-on-year, mainly driven by strong underlying market demand for Cresemba in key regions. Product revenue amounted to CHF 50.8 million (FY 2024: CHF 57.8 million), with the decrease resulting from the planned expiration of the product-supply agreement with Pfizer following the successful transfer of manufacturing for all adult formulations. Milestone and upfront payments totaled CHF 32.0 million (FY 2024: CHF 40.4 million), consistent with the average annual amount seen over the last years. Other revenue increased to CHF 38.0 million (FY 2024: CHF 13.7 million). This included CHF 30.9 million revenue related to the contracts with BARDA [ 1 ] (FY 2024: CHF 10.2 million) and CHF 4.3 million revenue related to the contract with CARB-X [ 2 ] (FY 2024: CHF 1.8 million). BARDA revenue is based on activities related to the fosmanogepix phase 3 program, the antifungal BAL2062, ceftobiprole, and ceftibuten-ledaborbactam, while CARB-X revenue is based on preclinical activities related to the antibiotic BAL2420 (the LptA inhibitor program). In 2025, Basilea invested CHF 105.9 million (FY 2024: CHF 77.1 million) in research and development (R&D), mainly related to the two ongoing phase 3 clinical studies of fosmanogepix in invasive yeast and mold infections, and for the upfront and milestone payments for the in-licensing of ceftibuten-ledaborbactam. It also includes expenses related to preparations for the upcoming phase 3 program of ceftibuten-ledaborbactam in complicated urinary tract infections, the preclinical profiling of BAL2062 and BAL2420, and for research work on compounds in the Company’s early-stage portfolio. These investments are fully in line with guidance and represent targeted capital allocation that we expect to translate into future revenue generation and long‑term value creation. Selling, general and administrative expenses, including costs for the commercialization of Cresemba and Zevtera, amounted to CHF 35.6 million (FY 2024: CHF 31.5 million) and cost of products sold amounted to CHF 39.3 million (FY 2024: CHF 38.7 million). Basilea recorded an operating profit of CHF 51.5 million (FY 2024: CHF 61.2 million). The year-on-year decrease is attributed to the CHF 12.0 million upfront and milestone payment for the in-licensing of ceftibuten-ledaborbactam; excluding this one-time effect, the operating profit for 2025 would have been higher than in 2024. In 2025, Basilea reported an income tax expense of CHF 5.6 million (FY 2024: CHF 17.3 million income tax benefit due to the one-time effect from releasing the deferred tax asset valuation allowance) and a net profit of CHF 40.2 million (FY 2024: CHF 77.6 million). The lower net profit in 2025 is the result of the absence of the one-time tax benefit recorded in 2024 and the tax expense recorded in 2025. The basic and diluted earnings per share in 2025 were CHF 3.29 and CHF 3.14, respectively (FY 2024: basic and diluted earnings per share CHF 6.42 and CHF 5.83, respectively). In 2025, a positive net cash flow of CHF 62.1 million was provided by operating activities (FY 2024: CHF 74.4 million). The Company also repurchased senior unsecured convertible bonds, due July 2027, in the amount of CHF 21.1 million nominal value out of a total CHF 97.1 million outstanding as of December 31, 2024. Cash, cash equivalents and restricted cash increased by 30% to CHF 162.3 million as of December 31, 2025 (December 31, 2024: CHF 124.6 million). Since the beginning of 2022, Basilea has reduced its total financial debt by approximately CHF 145 million. Further, in 2025 the net cash position increased to CHF 86.9 million as of December 31, 2025 (December 31, 2024: net cash of CHF 28.6 million). Key financial figures (in CHF million, except per share data) FY 2025 FY 2024 Product revenue 50.8 57.8 Contract revenue 143.6 137.0 Other revenue 38.0 13.7 Total revenue 232.4 208.5 Cost of products sold (39.3) (38.7) Research & development expenses, net (105.9) (77.1) Selling, general & administrative expenses (35.6) (31.5) Total cost and operating expenses (180.8) (147.4) Operating result 51.5 61.2 Profit before taxes 45.9 60.3 Income taxes (5.6) 17.3 Net profit 40.2 77.6 Net cash provided by operating activities 62.1 74.4 Basic earnings per share, in CHF 3.29 6.42 Diluted earnings per share, in CHF 3.14 5.83 (in CHF million) Dec 31, 2025 Dec 31, 2024 Cash and cash equivalents and restricted cash 162.3 124.6 Note: Consolidated figures in conformity with US GAAP; rounding was applied consistently. The consolidated financial statements of Basilea Pharmaceutica Ltd, Allschwil for the financial year 2025 can be found on the Company’s website at . 2026 financial guidance: 10% increase in total revenue driving 20% increase in operating profit Basilea provides the following guidance for the full year (FY) 2026: (in CHF million / percent) FY 2026e FY 2025 Total revenue ~10% increase 232.4 Research & development expenses, net ~20% increase 105.9 Operating profit ~20% increase 51.5 Total revenue is expected to increase by ~10%: Cresemba and Zevtera-related revenue is expected to increase to CHF ~200 million with a shift in revenue mix towards higher margin contract revenue, which results in an expected increased cash contribution to CHF ~170 million (~10% increase). The expected increase in royalty income to CHF ~120 million and in milestone payments to CHF ~35 million primarily reflects the continued strong double-digit sales growth of Cresemba in its key markets. It is expected to fully offset the negative impact from the strength of the Swiss Franc and the effect of the decrease in product revenue from Pfizer and Gosun, as both partners assume responsibility for the majority of their own supply. The expected ~20% increase of R&D expenses results from the progress in our R&D portfolio, especially the investments in the clinical development of our key near-term value drivers fosmanogepix and ceftibuten-ledaborbactam. While increasing investments in R&D, Basilea also expects to increase operating profitability, which is reflected in the expected disproportional ~20% increase in operating profit. Agenda 2030 By 2030, Basilea aims to launch two new products, fosmanogepix and ceftibuten-ledaborbactam, with the potential to double current in-market sales. The Company also plans to progress its existing earlier stage pipeline to support growth and value creation beyond fosmanogepix and ceftibuten-ledaborbactam. Basilea executes its growth strategy from a position of financial strength. Basilea reported CHF 162 million in cash as of December 31, 2025. Over the next five years, Basilea expects to add CHF 600 million in cumulative cash flows from Cresemba and Zevtera, supported by growing market demand and continued commercial execution. In addition, there is approximately USD 330 million of potential additional non-dilutive R&D funding awarded under Basilea’s existing agreements with BARDA, which may be committed in future tranches to support the development of fosmanogepix, BAL2062 and ceftibuten-ledaborbactam. The underlying commercial assumptions: Cresemba is expected to maintain robust in‑market sales momentum, with strong performance in the US until Q4 2027 and in Europe until the second half of 2028, when the first generics may potentially have an impact in these markets. Cresemba is expected to show significant in-market sales growth in Japan throughout the next five years, reflecting both expanding market penetration, the product’s differentiated clinical pro a longer market exclusivity. Zevtera is projected to gain momentum from Q2 2026 in the US, supported by ongoing commercial rollout and increasing clinician adoption. Basilea has sufficient financial strength and flexibility to bring its next growth drivers fosmanogepix and ceftibuten-ledaborbactam to the market, progress its earlier stage pipeline to support sustained mid-term growth and to seize external growth opportunities through the continued acquisition and in-licensing of the most promising assets. Potential upsides not considered in the above “Agenda 2030” include new non‑dilutive R&D funding agreements, later‑than‑anticipated entry of Cresemba generics in the US and Europe, and first revenues from fosmanogepix and ceftibuten-ledaborbactam. Nominations to the board of directors The board of directors has nominated for re-election Stephan Schindler as chairman and Leonard Kruimer, Dr. Nicole Onetto and Dr. Carole Sable for re-election as board members. After serving on the board of directors for 15 years and 13 years, respectively, Dr. Thomas Werner and Dr. Martin Nicklasson have decided not to stand for re-election. The company being in a strong position with an innovative pipeline, strong financials and a focused organization, they felt it was now the right time to step down and hand over to new board members. The board of directors is proposing the nomination of Anne Whitaker and Dr. Naseem Amin as new board members. Both are highly accomplished executives in the life science industry combining many years of experience across marketing, research & development, corporate & business development, governance and leadership roles. Anne Whitaker started her career as a pharmaceutical sales representative, taking over roles of increasing seniority and responsibility, including Vice President and Business Unit Head of the Cardiovascular, Metabolic, and Urology Business Division as well as Senior Vice President of Leadership and Organization Development for GlaxoSmithKline. Thereafter she served as president of North America Pharmaceuticals at Sanofi Aventis US LLC, as president and chief executive officer of Synta Pharmaceuticals Corporation, as executive vice president and group company chairman at Bausch Health Companies, Inc. (formerly Valeant Pharmaceuticals International, Inc.), as CEO and chairwoman of Aerami Therapeutics Holdings, Inc. (formerly Dance Biopharm Holdings, Inc.) and as President and CEO of Novoclem Therapeutics Inc. Anne Whitaker is currently serving on the boards of Icon Plc., Bespak Ltd., Trinity Life Sciences and QurAlis Corporation (chairwoman). She is also an advisor (operating partner) at New Vale Capital LLC. Ms. Whitaker was born and educated in the United States and holds US citizenship. Naseem Amin, M.D., practiced as a medical doctor and started his industry career at Baxter Healthcare, where he held executive roles in marketing, product development and clinical research. Thereafter he served as Vice President Business Development and Vice President Clinical Research at Genzyme Corporation, as Senior Vice President Business Development at Biogen Idec, Chief Scientific Officer at Smith & Nephew Plc, as Venture Partner at Advent Life Sciences LLP, as Executive Chairman at Arix Bioscience Plc and as Non-Executive Director at Avadel Plc. Naseem Amin is currently serving as a director and CEO of Orphalan SA. Dr. Amin was born in Pakistan; he was educated in the UK and the US and holds British and US citizenship. Conference call and webcast Basilea Pharmaceutica Ltd, Allschwil will host a conference call and webcast today, Tuesday, February 17, 2026, at 4 p.m. (CET), to discuss the company’s financial and operating results and to provide an outlook. Via audio webcast with presentation The live audio webcast of the results presentation can be followed here: . Please note that there is no function to ask questions via webcast. For questions, please additionally dial-in via phone (see below). Via phone To listen by phone and ask questions, please use the dial-in details below. To ensure prompt access, please call approximately five minutes prior to the scheduled start of the call. +41 (0) 58 310 5000 (Switzerland, Europe and RoW) +1 (1) 631 570 5613 (USA) +44 (0) 207 107 0613 (UK) Replay The webcast, along with the presentation will be available online (same link as live audio webcast above) shortly after the event and accessible for three months. Save the date – Basilea Capital Markets Day on October 28, 2026, in Zurich The event will provide the audience with a comprehensive update on the company’s strategic direction and value drivers and will include presentations from senior management and external experts. Further details on the agenda and registration will follow. About Basilea Basilea is a commercial-stage biopharmaceutical company founded in 2000 and headquartered in Switzerland. We are committed to discovering, developing and commercializing innovative drugs to meet the needs of patients with severe bacterial and fungal infections. We have successfully launched two hospital brands, Cresemba for the treatment of invasive fungal infections and Zevtera for the treatment of bacterial infections. In addition, we have preclinical and clinical anti-infective assets in our portfolio. Basilea is listed on the SIX Swiss Exchange (SIX: BSLN). Please visit basilea.com. Disclaimer This communication expressly or implicitly contains certain forward-looking statements, such as "believe", "assume", "expect", "forecast", "project", "may", "could", "might", "will" or similar expressions concerning Basilea Pharmaceutica Ltd, Allschwil and its business, including with respect to the progress, timing and completion of research, development and clinical studies for product candidates. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of Basilea Pharmaceutica Ltd, Allschwil to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Basilea Pharmaceutica Ltd, Allschwil is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise. For further information, please contact: Peer Nils Schröder, PhD Head of Corporate Communications & Investor Relations Basilea Pharmaceutica International Ltd, Allschwil Hegenheimermattweg 167b 4123 Allschwil Switzerland Phone +41 61 606 1102 E-mail media_relations@basilea.com investor_relations@basilea.com This ad hoc announcement can be downloaded from . References The U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority (BARDA), provided partial funding with federal funds for Basilea’s ceftobiprole phase 3 program under contract number HHSO100201600002C. This funding covered approximately USD 111 million, or about 75% of the costs for the Staphylococcus aureus bacteremia (SAB) and acute bacterial skin and skin structure infections (ABSSSI) phase 3 studies, regulatory activities, and non-clinical work. BARDA is also supporting Basilea’s fosmanogepix and BAL2062 programs under OTA number 75A50124C00033, and the ceftibuten-ledaborbactam program under contract number 75A50123C00050. CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) funding for this project is provided in part by federal funds from the US Department of Health and Human Services (HHS); Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority; Antibacterials branch; under agreement number 75A50122C00028; and by awards from Wellcome (WT224842) and Germany’s Federal Ministry of Education and Research (BMBF).