Delving into the Latest Updates on Hubei University of Science & Technology with Synapse

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Neoplasms

Nervous System Diseases

Immune System Diseases

Radiolabeled antibody

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

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Disease Domain	Count

Neoplasms	2
Immune System Diseases	1
Infectious Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1
Radiolabeled antibody	1

Top 5 Target	Count

VEGFR2(Vascular endothelial growth factor receptor 2)	1
STING(Stimulator of interferon genes)	1

Polymer blend membranes are an efficient and cost-effective route to improve the gas separation performance.The poor solubility and compatibility of the polymer are the main challenge to overcome in blend membranes procedures.Here, the incorporation of electron beam (EB) irradiation-induced polymer to membranes were reported to successfully avoid the poor solubility and compatibility between polymer.Specifically, small mol. glycidyl methacrylate (GMA) is dispersed into 6FDA-DAM membrane, 6FDA-DAM/PGMA blend membranes are obtained via EB-irradiation-polymerized GMA to form PGMA and deposit in DAM membrane in-situ.The loads of PGMA in 6FDA-DAM membrane (7.3 %-30.5 %) were controlled by EB-irradiation dosagess (from 60 kGy to 120 kGy).The resulted 6FDA-DAM/PGMA-x blend membranes showed a strong mol. sieve, such as the CO₂/CH₄ and H₂/CH₄ selectivity of 6FDA-DAM/PGMA-21.7 % membranes are improved by 352 % and 662 % compared with 6FDA-DAM, which exceed 2008 and 2015 upper bound.The enhanced performance results from incorporation of PGMA to form sub-nanometer-sized channel in 6FDA-DAM membrane.This work provides a facile and universal strategy to induce small mol. polymerization and in-situ incorporate to the membrane via EB-irradiation technol. for gas separation

01 Jun 2025·Journal of Environmental Sciences

Characterization and sources of childhood PAEs exposure from residential airborne dust in China cities

Article

Author: Liu, Mengmeng ; Tysklind, Mats ; Wang, Xianliang ; Li, Li ; Yang, Xu ; Fan, Lin ; Zhang, Wenying ; Wang, Chao ; Cao, Yun ; Zhang, Xiaotong ; Du, Hang ; Gong, Shuhan

To explore the multicenter characteristics of endocrine-like phthalate esters (PAEs) in household dust and propose effective control strategies for global indoor public health. An on-site observational investigation was conducted in nine Chinese cities from 2018 to 2019. A total of 246 household dust samples were collected and analyzed for ten PAE congeners using Gas Chromatography-Mass Spectrometry (GC-MS). Questionnaires were used to gather information on building conditions, indoor behaviors, and ventilation habits. In residential dust from the nine cities, the total concentrations of the ten PAE congeners (∑PAEs) ranged from 0.921 to 29097.297 µg/g. Dicyclohexyl phthalate (DCHP) and di (2-ethylhexyl) phthalate (DEHP) were the dominant congeners in ∑PAEs. Childhood exposure to PAEs through dust ingestion was four orders of magnitude higher than through inhalation, with a carcinogenic risk of 5.47 × 10^-6 for DEHP exposure in household dust. Higher ∑PAEs concentrations were associated with higher temperature, double glazing, wall paint usage, television and computer use, and indoor plant growth. This multicenter on-site investigation confirmed PAE pollution characteristics and uncovered the inacceptable risk of daily DEHP exposure in household dust under real living conditions. Effective mitigation measures based on household-related information, residential characteristics, decoration materials, and lifestyle should be taken to build a healthy household environment.

01 Jun 2025·Bioelectrochemistry

Highly sensitive electrochemical Osteoprotegerin (OPG) immunosensor for assessing fracture healing and evaluating drug efficacy

Article

Author: Liu, Kui ; Pang, Yan ; Li, Sichao ; Jaffrezic-Renault, Nicole ; Wang, Lu ; Guo, Zhenzhong ; Zhang, Zhipeng

Tibial fractures are common long bone injuries requiring effective monitoring for optimal healing. Osteoprotegerin (OPG), as a key marker of bone formation, is closely related to the degree of fracture healing. However, existing detection methods have certain limitations in sensitivity and specificity. This study successfully crafted an exceptionally sensitive electrochemical immunosensor based on COOH-CNFs/Ti₃C₂T_x MXene/PANI-AgNPs nanocomposite material for the quantitative analysis of OPG in serum, providing a methodological basis for auxiliary diagnosis of fracture healing degree and evaluation of drug efficacy. A one-pot hydrothermal method was employed to synthesize and modify the nanocomposite material on gold electrode surfaces, which exhibit high electrochemical activity, low charge transfer resistance, and a large electroactive surface area, thereby enhancing the immunosensor's conductivity and stability, with a wide linear range (10^-17 to 10^-12 g/mL) and a low detection limit (1.94 × 10^-18 g/mL). Methodological validation further confirmed the immunosensor's excellent performance in specificity, reproducibility, and stability. Moreover, the successful application of this immunosensor in detecting OPG in serum samples from actual tibial fracture patients before and after medication demonstrates significant potential for clinical application in assisting the assessment of fracture healing and evaluating the efficacy of orthopedic drugs.

100 Deals associated with Hubei University of Science & Technology

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100 Translational Medicine associated with Hubei University of Science & Technology

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Pipeline

Pipeline Snapshot as of 24 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Preclinical

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