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Neoplasms

Nervous System Diseases

Immune System Diseases

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Small molecule drug

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Disease Domain	Count

Neoplasms	2
Immune System Diseases	1
Infectious Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1
Radiolabeled antibody	1

Top 5 Target	Count

VEGFR2(Vascular endothelial growth factor receptor 2)	1
STING(Stimulator of interferon genes)	1

Herein, a novel pH-responsive adsorbent with selective adsorption effect on cationic and anionic dyes was further designed and prepared via radiation grafting in situ growth technique.The cheap, modifiable and benign natural renewable biomass loofah (LFs) was selected as the substrate, and then acrylic acid (AAc) was grafted onto the loofah substrate through electron beam (EB) radiation (grafting rate of 30.5 %).The introduction of -COOH effectively captured and fixed cobalt ions (Co²⁺), and zeolitic imidazolate framework-67 (ZIF-67) was grown in situ on the loofah surface with Co²⁺ as a metal center and 2-methylimidazole as the ligand, so a functional loofah-based adsorbent ZIF-67@LFs-AAc was obtained.The introduction of ZIF-67 significantly enhanced the adsorption efficiency and capability of biomass materials, and successfully combined the advantages of biomass and inorganic nanomaterials.The biosorbent is pH-responsive and can specifically adsorb anionic dyes in acidic setting.The equilibrium uptake capacity of Congo red (CR) is 433.9 mg/g at pH = 3.Cationic dyes can be selectively adsorbed under neutral and basic conditions, and the equilibrium uptake capacity of methylene blue (MB) is as high as 554.0 mg/g at pH = 7.When the addition of the ZIF-67@LFs-AAc was 1.0 g/L, the removed rates of MB and CR were 95.9 % and 91.8 %, resp.With ZIF-67@LFs-AAc, the adsorption of dyes is promoted by electrostatic interaction, pore adsorption, π-π interaction and hydrogen bond.In summary, the integration of MOFs with loofah can lead to the development of a highly efficient biosorbent for treating dye-containing wastewater, thereby offering promising prospects for its application in water treatment.

01 Jan 2025·Journal of Molecular Structure

Bioimaging research of a turn-on homodimer fluorescent probes for pH and viscosity: A new turn-on strategy

Author: Gao, Tao ; Zhang, Lu ; Xiang, Lingli ; Zhen, Yali ; Sang, Yanan ; Chen, Tao ; Dan, Liangfeng ; Xiang, Yu ; Yan, Ke ; Du, Linli ; Ning, Xiaojun ; Wang, Wei ; Yuan, Bin ; Min, Shuang

A turn-on homodimer fluorescent probe (BL) that responded to pH and viscosity was facilely synthesized based on homo-FRET.The probe exhibited strong fluorescence intensity and color changes in alk. pH.In addition, the probe′s fluorescence had altered with changes in viscosity.What′s more, Mitochondrial localization and pH bioimaging in E. coli cell experiments confirmed that BL was a novel multifunctional probe that could be applied to mitochondrial-targeted fluorescence imaging under normal conditions and real-time fluorescence imaging of E. coli under alk. conditions.

31 Dec 2024·All Life

Ferroptosis plays a role in osteoarthritis

Author: Tao, Xu ; Altahla, Ruba ; Alshorman, Jamal

In recent years, ferroptosis has been identified as a novel type of regulated cell death.As a cell death process, it differs from other processes like necrosis and apoptosis in the expression of morphol., biochem., and genetics.Ferroptosis provides a new view of programmed cell death.It is initiated by the oxidation of lipids, reactive oxygen species (ROS) formation and iron buildup within cells, leading to their demise.The identification of these biochem. events triggering ferroptosis has expanded understanding of controlled cellular suicide.A significant role of ferroptosis in osteoarthritis (OA) has been reported in recent studies.Both OA and ferroptosis exhibit anomalies in metabolism of iron, oxidation of lipids, and mitochondrial dysfunction.Nonetheless, our understanding of the specific genes involved in regulating ferroptosis in the context of OA is currently limited.Expanding our knowledge in this area could have profound implications for effectively managing and treating OA.This review offers an in-depth exploration of the mol. processes associated with ferroptosis.Furthermore, we discuss the roles of ferrioptosis in different aspects of osteoarthritis, encompassing the degradation of cartilage, synovitis, dysfunction of chondrocytes, and the manifestation of OA-related pain.We highlight the potential of targeting ferroptosis for OA treatment.

100 Deals associated with Hubei University of Science & Technology

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100 Translational Medicine associated with Hubei University of Science & Technology

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

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Preclinical

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