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Author: Lakshmi, Josyula K ; Prabhakaran, Dorairaj ; Kapoor, Deksha ; Farzana, Noshin ; Mousa, Aya ; Cooray, Shamil D ; Patel, Anushka ; de Silva, H Asita ; Billot, Laurent ; Baker, Susanne ; Naheed, Aliya ; Ajanthan, Saumiyah ; Teede, Helena ; Gupta, Ishita ; Tandon, Nikhil ; Belsti, Yitayeh ; Chakma, Nantu ; John, Renu ; Desai, Ankush ; Bhatla, Neerja ; Gupta, Yashdeep ; Zoungas, Sophia ; Enticott, Joanne ; Praveen, Devarsetty ; Goldstein, Rebecca ; Moran, Lisa J

AIMSThis study aimed to develop a prediction model for identifying a woman with gestational diabetes mellitus (GDM) at high risk of type 2 diabetes (T2DM) post-birth.METHODSUtilising data from 1299 women in the Lifestyle Intervention IN Gestational Diabetes (LIVING) study, two models were developed: one for pregnancy and another for postpartum. Key predictors included glucose test results, medical history, and biometric indicators.RESULTSOf the initial cohort, 124 women developed T2DM within three years. The study identified seven predictors for the antenatal T2DM risk prediction model and four for the postnatal one. The models demonstrated good to excellent predictive ability, with Area under the ROC Curve (AUC) values of 0.76 (95% CI: 0.72 to 0.80) and 0.85 (95% CI: 0.81 to 0.88) for the antenatal and postnatal models, respectively. Both models underwent rigorous validation, showing minimal optimism in predictive capability. Antenatal model, considering the Youden index optimal cut-off point of 0.096, sensitivity, specificity, and accuracy were measured as 70.97%, 70.81%, and 70.82%, respectively. For the postnatal model, considering the cut-off point 0.086, sensitivity, specificity, and accuracy were measured as 81.40%, 75.60%, and 76.10%, respectively.CONCLUSIONSThese models are effective for predicting T2DM risk in women with GDM, although external validation is recommended before widespread application.

01 Aug 2024·INDIAN JOURNAL OF APPLIED RESEARCH

PRIMARY SYNOVIAL CHONDROMATOSIS : A CASE REPORT

Author: A. K., Aiswarya ; Sousa Rocha, Premila De ; S. Bhat, Rajika ; Naik Dessai, Saheel

Synovial chondromatosis is a rare benign condition of the synovial membrane of joints, bursae or tenosynovial sheaths characterized by the formation of multiple cartilagenous nodules or osseus loose bodies . It is usually a monoarticular disease, and 33 different localizations have been described until now.(1). It typically presents with large joint effusion, and joints may appear deformed due to swelling or synovial hypertrophy. Synovial chondromatosis can result in severe disability and dysfunction. However, most cases are benign , and this condition rarely undergoes malignant transformation. The initial diagnosis of synovial chondromatosis is made through a thorough history, physical examination and radiological evaluation of an affected joint.(2). Primary synovial chondromatosis (also known as Reichel syndrome or Reichel-Jones-Henderson syndrome), is a benign monoarticular disorder of unknown origin that is characterized by synovial metaplasia and proliferation resulting in multiple intra- articular cartilaginous loose bodies of relatively similar size, not all of which are ossied. Hence, the term synovial chondromatosis is preferred over primary synovial osteochondromatosis(3). Primary synovial chondromatosis typically affects the large joints in the third to fth decade of life, although involvement of smaller joints and presentation in younger age group is also documented.(4). We present a review of the literature and report a case of primary synovial chondromatosis of the knee joint in a 32 year old male.

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