Tonghua Wantong Pharmaceutical Co. Ltd.

Primary objective: To observe the pharmacokinetic characteristics of the test preparation ibuprofen sustained-release capsules (specification: 0.3g; manufacturer: Tonghua Wantong Pharmaceutical Co., Ltd.) and the reference preparation ibuprofen sustained-release capsules (trade name: Fenbid®; specification: 0.3g; manufacturer: Sino-US Tianjin SmithKline Pharmaceutical Co., Ltd.; drug marketing authorization holder: Sino-US Tianjin SmithKline Pharmaceutical Co., Ltd.) in Chinese healthy participants after a single oral administration in the fasting/postprandial state, and to evaluate the bioequivalence of the two preparations in the fasting/postprandial state. Secondary objective: To observe the safety of the test preparation ibuprofen sustained-release capsules and the reference preparation ibuprofen sustained-release capsules (Fenbid®) in Chinese healthy participants.

To evaluate the effectiveness of Wantong Muscle and Bone Babu Paste in improving the clinical symptoms and signs of shoulder periarthritis (wind-cold obstruction syndrome) with pain as the main clinical manifestation. To observe the safety of Wantong Muscle and Bone Babu Paste in clinical application.

Primary objective: To observe the pharmacokinetic characteristics of the test preparation metformin glibenclamide tablets (specification: 500mg/2.5mg) and the reference preparation metformin glibenclamide tablets (trade name: Glucovance®; specification: 500mg/2.5mg; licensee: Merck SANTE S.A.S) after a single oral administration in the fasting/postprandial state in healthy Chinese subjects, and to evaluate the bioequivalence of the two preparations in the fasting/postprandial state. Secondary objective: To observe the safety of the test preparation metformin glibenclamide tablets and the reference preparation metformin glibenclamide tablets (Glucovance®) in healthy Chinese subjects.