[Translation] A randomized, double-blind, placebo-controlled, dose-escalation Phase Ia clinical study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BGM0504 injection in healthy volunteers after single administration and weekly administration for two weeks, gradually increasing to the target dose
主要目的:评价 BGM0504 注射液在健康志愿者中单次给药及每周给药 1 次渐进到目标剂量的安全性和耐受性;评价 BGM0504 注射液在健康志愿者中单次给药及每周给药 1 次渐进到目标剂量的药代动力学特征。 次要目的:初步评价 BGM0504 注射液在健康志愿者中单次给药及每周给药 1 次渐进到目标剂量的药效学特征。
[Translation] Primary objective: To evaluate the safety and tolerability of BGM0504 injection in healthy volunteers after single administration and once-weekly administration to the target dose; to evaluate the pharmacokinetic characteristics of BGM0504 injection in healthy volunteers after single administration and once-weekly administration to the target dose. Secondary objective: To preliminarily evaluate the pharmacodynamic characteristics of BGM0504 injection in healthy volunteers after single administration and once-weekly administration to the target dose.