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Nervous System Diseases	1

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MSTN(Growth/differentiation factor 8)	1

AbstractKeratinocytes are the primary component of the epidermis, so maintaining the precise balance between proliferation and differentiation is essential for conserving epidermal structure and function. Rosae multiflorae fructus extract (RMFE) has wide application in the cosmetic industry, but the molecular mechanisms underlying beneficial effects on keratinocytes are still not fully understood. In this study, we found that RMFE promoted epidermal differentiation and enhanced the barrier function of normal human epidermal keratinocytes (NHEKs) and three-dimensional epidermis model in culture. In addition, RMFE promoted human umbilical vein endothelial cell (HUVEC) proliferation and angiogenesis, whereas the conditioned medium from RMFE-treated HUVECs further promoted NHEK proliferation and increased wound healing ability. Analysis of constituent bioactivities identified a quercetin derivative as a potential mediator of NHEK and HUVEC responses to RMFE. Taken together, these results suggest that RMFE enhances epidermal functions through both direct effects on keratinocytes and indirect effects mediated by endothelial cells.

01 Apr 2025·The Journal of Sports Medicine and Physical Fitness

Effect of clapping movement with groove rhythm on executive function: focusing on audiomotor entrainment

Article

Author: Soya, Hideaki ; Fukuie, Takemune ; Suwabe, Kazuya ; Yamaguchi, Akihiko ; Inoue, Koshiro ; Kawase, Satoshi

BACKGROUNDGroove rhythm, known for inducing the desire to move to music, could enhance the cognitive benefits of exercise, especially in individuals familiar with groove. Audiomotor entrainment and concurrent positive affect are considered key modulating factors in the effects of exercise set to groove rhythm. Clapping movement could facilitate audiomotor entrainment, which may benefit positive affect and cognition. This study aimed to examine the effect of clapping with groove rhythm (CL) on audiomotor entrainment, positive affect, and executive function (EF).METHODSThirty-three healthy university students participated in two experiments. In Experiment 1, psychological responses to 2-minute exercise were assessed across two conditions: CL condition and non-clapping and arm rotation movement with groove rhythm (NC condition). In Experiment 2, participants performed 3-minute CL and NC on separate days, and the color-ward Stroop test and psychological measures were evaluated.RESULTSCL increased subjective audiomotor entrainment and positive affect more than NC. However, no effect on EF was observed. Correlation analysis revealed higher subjective audiomotor entrainment and positive affect in the CL condition were associated with EF improvement.CONCLUSIONSClapping is a preferable exercise type for subjective audiomotor entrainment and positive affect, but the effect on EF varied among individuals. Subjective audiomotor entrainment and positive affect could modulate the effect of CL on EF.

01 Apr 2025·American Journal of Pharmaceutical Education

Exploring Instructor-Led Team Formation and Task Assignment to Enhance Group Dynamics in Pharmacy Problem-Based Learning

Article

Author: Utsumi, Miho ; Shimomura, Yuki

OBJECTIVEThis study investigates how different team grouping methods and task assignments affect group dynamics, specifically focusing on the presence of free riders and active learners (students who fully engage and contribute to the group).METHODSThis study was conducted in 2020 as part of a problem-based learning program in physical chemistry and pharmaceutics. A total of 255 second-year students were randomly assigned to 1 of 3 groups: (1) motivation-based, (2) grade-based, and (3) random. They were then divided into teams based on career prospects, academic performance, radom assignment. Data were collected using postprogram questionnaires which included demographic information, learning behaviors, and peer evaluations. Statistical analyses, including χ² tests and analysis of variance, were used to compare group dynamics and learner characteristics. Qualitative comments on team performance were analyzed through coding and categorization.RESULTSThe grade-based group had the highest number of free riders, whereas the motivation-based group had the most active learners. Free riders demonstrated lower grades and self-evaluations, whereas active learners exhibited higher grades and leadership roles. Motivation-based grouping, which aligns team tasks with students' career prospects, was associated with higher engagement and fewer free riders. Grouping students based on career prospects promoted active learning, whereas grouping by academic performance increased free riding.CONCLUSIONGrouping students from various academic performance levels may not yield positive outcomes, whereas grouping based on career prospects has the potential to enhance student motivation and engagement.

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Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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