Delving into the Latest Updates on Kobe Gakuin University with Synapse

Overview

Tags

Nervous System Diseases

ASO

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	1

Top 5 Drug Type	Count

ASO	1

Top 5 Target	Count

MSTN(Growth/differentiation factor 8)	1

Dialkylamino groups are elec. neutral π-electron-donating groups (πEDGs) typically used in push-pull benzene π-conjugated systems to shift their absorption toward longer wavelengths.To push the upper limit of the π-electron donation imposed by the dialkylamino groups while maintaining the neutral net elec. charge, we developed novel ylidic nitrogen-based πEDGs, (quinuclidinio)amidyl (QA) and (1-azanorbornio)amidyl (ANA) groups, which were introduced to push-pull benzenes through nucleophilic aromatic substitution.The bicyclic ammonium structures incorporated in these groups enhanced their thermal stability and π-electron-donating ability.The QA and ANA groups donate more π-electrons than the pyrrolidinyl group, as demonstrated by comparing their σ⁺DCM values and conducting a competitive electrophilic bromination experimentChanging the pyrrolidinyl group to the QA or ANA group achieved a bathochromic shift of 45-100 nm in the maximum absorption wavelength, depending on the push-pull π-conjugated system investigated (p-nitrobenzene, 1,8-naphthalimide, and an azo dye).

01 Sep 2024·General Hospital Psychiatry

Comprehensive signal detection of delirium-associated medication using the Food and Drug Administration Adverse Event Reporting System

Article

Author: Mizumura, Ryosuke ; Shin, Kenji ; Ishikawa, Akira ; Yamada, Shigeki ; Sogawa, Rintaro ; Hatano, Masakazu ; Araki, Haruna ; Esumi, Satoru

OBJECTIVESeveral medications are associated with delirium; however, studies with adequate statistical power are limited, and it is difficult to determine the effects of the various concomitant medications used in clinical practice. Therefore, in this study, we aimed to comprehensively evaluate the safety signals of delirium-associated drugs using a spontaneous adverse event reporting system.METHODThe JAPIC AERS (Food and Drug Administration Adverse Event Reporting System pre-processed by the Japan Pharmaceutical Information Center) was used for the analysis in this pharmacovigilance study. The reporting odds ratio (ROR) for delirium was adjusted for using multivariate logistic regression analysis with sex, age, indication, and melatonin receptor agonist use, and 22 drug categories were targeted as covariates.RESULTSAfter excluding patients with missing information, 7,527,568 patients were included in the study. Delirium signals were detected even after adjusting for covariates in 17 drug categories, including benzodiazepines (adjusted ROR, 1.76; 95% confidence interval [CI], 1.64-1.89), opioids (adjusted ROR, 4.42; 95% CI, 4.21-4.64), and tricyclic antidepressants (adjusted ROR, 2.44; 95% CI, 2.20-2.71).CONCLUSIONSThese findings suggest that many drug classes, such as benzodiazepines, are independent risk factors for delirium and strengthen the evidence of an association between delirium and medications.

01 Sep 2024·Brain Research

Spinal lipocalin 2 as a factor in the development of central post-stroke pain

Article

Author: Tokuyama, Shogo ; Nakamoto, Kazuo

Central poststroke pain (CPSP) is a type of central neuropathic pain whose mechanisms remain unknown. Recently, we showed that activated astrocytes and microglial cells are present in the spinal cord of CPSP model mice. Activated glial cells exacerbate cerebral ischemic pathology by increasing the expression of inflammatory factors. However, the involvement of spinal glial cells in CPSP remains unknown. We hypothesized that spinal glial cell-derived molecules cause hyperexcitability or promoted the development of CPSP. In this study, we identified glial cell-derived factors involved in the development of CPSP using a bilateral common carotid occlusion (BCAO)-induced CPSP mouse model. Male ddY mice were subjected to BCAO for 30 min. The von Frey test assessed mechanical hypersensitivity in the right hind paw of mice. BCAO mice showed hypersensitivity to mechanical stimuli and astrocyte activation in the spinal cord 3 days after treatment. DNA microarray analysis revealed a significant increase in lipocalin 2 (LCN2), is known as neutrophil gelatinase-associated lipocalin, in the superficial dorsal horns of BCAO-induced CPSP model mice. LCN2 colocalized with GFAP, an astrocyte marker. Spinal GFAP-positive cells in BCAO mice co-expressed signal transducer and activator of transcription 3 (STAT3). The increase in the fluorescence intensity of LCN2 and GFAP in BCAO mice was suppressed by intrathecal injection of AG490, an inhibitor of JAK2 and downstream STAT3 activation, or anti-LCN2 antibody. Our findings indicated that LCN2 in spinal astrocytes may be a key molecule and may be partly involved in the development of CPSP.

100 Deals associated with Kobe Gakuin University

Login to view more data

100 Translational Medicine associated with Kobe Gakuin University

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Login to view more data