Objective: This study investigates mucin expression patterns in gastric adenocarcinoma (GAC),
examining neutral, sialomucins, and sulfomucins using histochemistry. We aim to correlate histological
grading and molecular classication with mucin histochemistry offering potential diagnostic and prognostic markers. These
ndings contribute to understanding the complex interplay between mucin alterations, molecular pathways, and clinical
outcomes in GAC. This observational study, conducted from March 2021 to August 2022, included 50 Materials and Methods:
cases of gastric adenocarcinoma. It utilized both prospective and retrospective approaches to gather specimens and employed
histochemical staining techniques to assess mucin changes. Data analysis was performed using SPSS 20.0, focusing on mucin
expression patterns across different histopathological variants. Our ndings revealed age and sex d Results: istribution trends,
distinct tumor histological patterns, and signicant peri-neural and lymphovascular invasion. In diffuse gastric
adenocarcinoma, mucin staining patterns indicate increased mucin production and a shift toward neutral mucin. Conversely,
intestinal-type gastric adenocarcinoma exhibits strong positivity for intestinal-type mucin components and sialomucins, with
signicant sulphomucin presence. In our study, we explored various clinicopathological aspects of g Conclusion: astric
adenocarcinoma (GAC) and delved into mucin staining patterns. These results contribute to a deeper understanding of GAC
characteristics with potential clinical implications.