To compare the efficacy of transdermal diclofenac, ketoprofen and lidocaine patch in post operative pain outcome in modified radical mastectomy patients and consumption of opioid in first 24 hours via patient controlled analgesia pump - nil

Start Date12 Mar 2025

Sponsor / Collaborator

Swami Rama Himalayan University

CTRI/2024/11/076412

/ Not yet recruitingPhase 4IIT

Dexmedetomidine versus low molecular weight dextran as adjuvant to Ropivacaine in ultrasound guided erector spinae plane block for postoperative analgesia in Total Abdominal Hysterectomy - nil

Start Date20 Nov 2024

Sponsor / Collaborator

Swami Rama Himalayan University

CTRI/2024/08/072923

/ Not yet recruitingNot ApplicableIIT

Carbon Footprints of Sevoflurane v/s Desflurane in the pediatric population: Roadmap to green Anesthesia - NIL

Start Date01 Sep 2024

Sponsor / Collaborator

Swami Rama Himalayan University

100 Clinical Results associated with Swami Rama Himalayan University

0 Patents (Medical) associated with Swami Rama Himalayan University

784

Literatures (Medical) associated with Swami Rama Himalayan University

01 Jun 2025·Current Medicinal Chemistry

Evaluation of Efficacy of Curcumin and Caffeic Acid Phenethyl Ester in Breast Cancer by Preclinical Studies

Article

Author: Avadhesh ; Narula, Acharan Singh ; Srivastava, Ankit ; Shekher, Anusmita ; Gupta, Subash Chandra ; Verma, Sumit Singh ; Dhasmana, Anupam

Aims::The aim of this study was to evaluate the combined and comparative efficacy of Caffeic acid phenethyl ester (CAPE) and curcumin in breast cancer.background:CAPE and curcumin are a class of phenolics. While curcumin is obtained from turmeric, CAPE is found in Baccharis sarothroides and Populus deltoides. Both agents are reported to produce activities in some cancer types. The combined and the comparative effects of two agents in breast cancer is not yet reported.objective:We evaluated the potential of CAPE and curcumin in both in vitro and in vivo breast cancer models.method:Human breast cancer cell lines, MDA-MB-231 and MCF-7 were exposed to CAPE and curcumin followed by functional assays such as cell cytotoxicity, cell proliferation and colony formation, cell cycle, mitochondrial membrane potential, apoptosis, and monodansylcadaverine (MDC) staining for autophagy. Computational analyses and mice model were also used.result:Employing computational analyses, both agents were found to exhibit drug like properties. Both molecules interacted with the key molecules of the NF-B pathway. CAPE and curcumin inhibited cell proliferation, colony formation, and invasion, and triggered apoptosis and autophagy in breast cancer cells. CAPE was found to be more effective in comparison to curcumin. Two agents working together were more effective than each agent working alone. Both agents suppressed the expression of survivin, Bcl-xL and GLUT-1. Further, cleaved PARP was increased by both agents. An induction in ROS generation was observed by both phenolics. Further, both molecules triggered a dissipation in mitochondrial membrane potential. In mice model implanted with Ehrlich-Lettre ascites carcinoma (EAC) cells, both drugs inhibited the growth of the tumour. The phenolics also modulated the metabolic parameters in tumour bearing mice.conclusion:The observations suggest that the combination of curcumin plus CAPE may be better in comparison to individual molecule.other:The study opens a window for analysing the efficacy of combination of CAPE and curcumin by more animal studies. This will provide a basis for examining the combined efficacy of two agents by clinical trial.

01 Jun 2025·Applied Radiation and Isotopes

Study of radiation exposure to radon in groundwater using scintillation-based RnDuo technique: A statistical analysis for risk assessment

Article

Author: Ramola, R C ; Wadhwa, Manoj ; Aswal, R S ; Negi, Jagmohan Singh ; Singh, Jaswinder ; Prasad, Mukesh ; Shrivastava, Utpal ; Negi, R S ; Singh, Krishna Pal

Radon in household water, particularly from groundwater sources, is a well-known health concern. Radon in groundwater is typically produced by radium in the aquifer's rocks, which may be originated from geogenic uranium or be transported from distant areas. In this study, radon levels were measured for the first time in groundwater samples (N = 80) collected from the foothills of the Kumaun Himalaya using the scintillation-based RnDuo technique, with the aim to assess whether exposure to radon in the water poses a significant health risk to the general public. Some (N = 41) of these samples were also analyzed using inductively coupled plasma mass spectrometry (ICP-MS) and LED fluorimetry for uranium concentrations, to investigate if geogenic uranium is source of radon in groundwater. The estimated health risks of radon and uranium in the analyzed water samples suggest no potential danger to the public. Weak correlations were observed between radon and uranium concentrations, indicating that the source of radon in groundwater is not related to local geogenic uranium mineralization. The findings will be valuable for future research on radionuclide exploration and radiation protection applications.

01 May 2025·International Journal of Biological Macromolecules

Exploration of compositional, functional, nutraceutical, and metabolites of Ram kandmool (Agave sisalana Perrine) for potential application in food systems

Article

Author: Rawat, Mahek ; Kumar, Arun ; Choudhary, Aditya ; Naik, Bindu ; Rustagi, Sarvesh ; Bhatt, Saurav ; Gupta, Arun Kumar ; Kumar, Vijay ; Varshney, Aditi ; Jha, Avinash Kumar ; Kheto, Ankan ; Pratiksha ; Makroo, Hilal A ; Kandpal, Rohan

The present study examined the food value, techno-functional properties, and potential metabolites of Agave sisalana Perrine (Ram kandmool, RKM) flour. The proximate analysis revealed that RKM flour has a moisture content (10.74 %), fat content (1.12 %), protein content (5.42 %), and crude fiber content (11.35 %). The total carbohydrate content was 15.11 %, with an energy value of 385.76 kJ 100 g^-1, and total sugar content of 36.61 mg glucose g^-1. Additionally, the high total phenolic content (310.79 mg GAE g^-1) and total flavonoid content (51.32 mg QE g^-1) highlight its significant antioxidant properties, as evidenced by DPPH* and ABTS scavenging activities of 71.22 % and 93.68 %, respectively. Functional properties such as solubility index increase with temperature, indicating good solubility in hot food preparations, while the swelling ratio peaks at 70 °C, making it a valuable thickening agent. FTIR, SEM, LCMS, and amino acid analysis revealed a complex chemical composition, high surface area due to the rough, porous surface of RKM fibers, and significant health-benefiting compounds, respectively. Overall, RKM flour's diverse nutritional and functional properties, high mineral content, and significant antioxidant properties make it a valuable ingredient for food formulations aimed at improving health outcomes.

100 Deals associated with Swami Rama Himalayan University

100 Translational Medicine associated with Swami Rama Himalayan University

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