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Effectiveness of the immune response in the form of the production of specific antibodies against immunogenic peptide constructs composed of conservative fragments of the hepatitis C virus envelope protein E2 depended on the adjuvants and carriers used in their preparations. The most effective formation of specific antibodies was observed in response to the injection of peptide constructs containing B- and T-epitopes of the E2 protein conjugated with a carrier with adjuvant properties, Immunomax. Antibodies obtained in response to immunization with conjugates of peptide constructs with Immunomax bound both hepatitis C virus envelope protein E2 and the heterodimer of envelope proteins E1E2.

23 Apr 2024·Russian Journal of Pain

Analgesic effect of externally applied and/or intraperitoneal hemantane and diclofenac in rats with postoperative pain

Author: Vasilchuk, A.G. ; Voronina, T.A. ; Ivanova, E.A. ; Matyushkin, A.I.

Objective. To evaluate the effect of hemantane administered by external application, intraperitoneal injection and combined external and intraperitoneal administration in rats with postoperative pain compared to diclofenac. Material and methods. Mechanical (von Frey test) or thermal (plantar test) hyperalgesia in rats was recorded for 4 days after surgery (longitudinal incisions of skin and flexor digitorum brevis muscle of the hind paw). Hemantane and diclofenac were applied to the paw and/or administered intraperitoneally twice a day on the day of surgery and 3 days after it. Results. Hemantane administered by external application (5% gel), intraperitoneal injection (10 mg/kg) and combined maneuver significantly reduced mechanical postoperative hyperalgesia. The effect of hemantane was superior the effect of diclofenac (5 mg/kg, 1% gel) when administered intraperitoneally or by combined approach. Effect of hemantane and diclofenac gels was similar. Both drugs had no significant effect on thermal postoperative hyperalgesia when administered via external or intraperitoneal route alone. Hemantane and diclofenac influenced thermal hyperalgesia only after topical application and simultaneous intraperitoneal injection. Conclusion. Low-affinity non-competitive NMDA receptor antagonist hemantane reduces mechanical hyperalgesia in rats with postoperative pain when applied topically (5% gel), intraperitoneally (10 mg/kg) or via both routes. Its effect is no inferior to diclofenac (5 mg/kg, 1% gel). Hemantane and diclofenac influenced thermal hyperalgesia only after topical application and simultaneous intraperitoneal injection.

01 Apr 2024·Pharmaceutical Chemistry Journal

Formulating GML-1 Tablets Using the Harrington Desirability Function

Author: Gavrilov, D. I. ; Blynskaya, E. V. ; Alekseev, K. V. ; Tishkov, S. V.

Features of using the generalized Harrington desirability function for the selection of a binder and lubricant for GML-1 (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide) tablets are considered.The factors affecting the characteristics of the finished dosage form are evaluated.Model formulations with different qual. and quant. compositions of disintegrant and lubricant excipients were developed.Their pharmaceutical and technol. properties were studied.The factors having the greatest impact on indicators such as the mass loss on drying, strength, disintegration, and solubility of the tablets were identified.The type and amount of disintegrant and lubricant in the tablet that could produce a dosage form with the optimal pharmaceutical and technol. characteristics were determined

100 Deals associated with Research Zakusov Institute of Pharmacology

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Pipeline

Pipeline Snapshot as of 09 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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