Delving into the Latest Updates on Nanjing Huawe Medicine Technology Development Co., Ltd. with Synapse

Overview

Tags

Neoplasms

Small molecule drug

Therapeutic vaccine

mRNA vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	4

Top 5 Drug Type	Count

Small molecule drug	6
Therapeutic vaccine	1
mRNA vaccine	1

Top 5 Target	Count

PD-1 x PDL1	1
EGFR L858R(EGFR exon 21 L858R mutation)	1
AT1R(Angiotensin II Receptor Type 1)	1
HBX(Protein X)	1
AXL(AXL receptor tyrosine kinase)	1

[Translation] A single-center, randomized, open-label, two-dose, fasting and fed, single-dose, two-period, double-crossover bioequivalence study of posaconazole enteric-coated tablets from Kangyuan Huawei Pharmaceutical Co., Ltd. and posaconazole enteric-coated tablets from Merck Sharp & Dohme Ltd (trade name: Nocofil®) in healthy Chinese subjects

以康缘华威医药有限公司的泊沙康唑肠溶片（100 mg）为受试制剂，Merck Sharp & Dohme Ltd上市的诺科飞®（NOXAFIL®，规格100 mg）为参比制剂，考察两制剂在空腹及餐后状态下单次给药的药代动力学参数及相对生物利用度，评价两制剂是否具有生物等效性，同时评价两制剂在健康受试者中的安全性。

[Translation]

Posaconazole enteric-coated tablets (100 mg) produced by Kangyuan Huawei Pharmaceuticals Co., Ltd. were used as the test preparation, and NOXAFIL® (100 mg) marketed by Merck Sharp & Dohme Ltd was used as the reference preparation. The pharmacokinetic parameters and relative bioavailability of the two preparations after single administration in the fasting and postprandial states were investigated to evaluate whether the two preparations were bioequivalent, and the safety of the two preparations in healthy subjects was evaluated.

Start Date09 Sep 2021

Sponsor / Collaborator

Nanjing Huawe Medicine Technology Development Co., Ltd.

CTR20202353

/ TerminatedNot Applicable

注射用左泮托拉唑钠对比注射用泮托拉唑钠治疗急性上消化道溃疡出血的安全性及有效性多中心、随机、双盲、非劣效、阳性药物平行对照的临床研究

[Translation] A multicenter, randomized, double-blind, non-inferiority, positive drug parallel controlled clinical study on the safety and efficacy of levopantoprazole sodium injection versus pantoprazole sodium injection in the treatment of acute upper gastrointestinal ulcer bleeding

主要目的：与注射用泮托拉唑钠对照，评价注射用左泮托拉唑钠治疗急性上消化道溃疡出血的有效性。次要目的：与注射用泮托拉唑钠对照，评价注射用左泮托拉唑钠治疗急性上消化道溃疡出血的安全性。

[Translation]

Primary objective: To evaluate the effectiveness of levopantoprazole sodium injection in the treatment of acute upper gastrointestinal ulcer bleeding by comparing with pantoprazole sodium injection. Secondary objective: To evaluate the safety of levopantoprazole sodium injection in the treatment of acute upper gastrointestinal ulcer bleeding by comparing with pantoprazole sodium injection.

Start Date15 Dec 2020

Sponsor / Collaborator

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

[+1]

CTR20201101

/ CompletedPhase 3

丁酸氯维地平脂肪乳注射液治疗高血压急症的随机、单盲、阳性平行对照、多中心、 III 期临床试验

[Translation] A randomized, single-blind, positive parallel-controlled, multicenter, phase III clinical trial of clevidipine butyrate fat emulsion injection in the treatment of hypertensive emergencies

以盐酸尼卡地平注射液为对照，评价丁酸氯维地平脂肪乳注射液治疗高血压急症患者的安全性和有效性。

[Translation]

To evaluate the safety and efficacy of clevidipine butyrate fat emulsion injection in the treatment of patients with hypertensive emergencies, using nicardipine hydrochloride injection as a control.

Start Date04 Aug 2020

Sponsor / Collaborator

Nanjing Huawe Medicine Technology Development Co., Ltd.

100 Clinical Results associated with Nanjing Huawe Medicine Technology Development Co., Ltd.

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0 Patents (Medical) associated with Nanjing Huawe Medicine Technology Development Co., Ltd.

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2

Literatures (Medical) associated with Nanjing Huawe Medicine Technology Development Co., Ltd.

Zhongguo Yaoke Daxue Xuebao

Synthesis process of tofisopam

Author: Wu, Kai ; Jiang, Yuwei ; Zhang, Xiaoqing ; Liu, Bao ; Sun, Ruiqin

The target product, tofisopam, is synthesized from com. available isoeugenenyl Me ether via two-step process with overall yield of 48%.The two-step process contains the steps of (1) polymerization and oxidation of isoeugenenyl Me ether to give 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-5-pentanone and (2) cyclization of 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-5-pentanone with hydrazine hydrate to give 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine that was tofisopam.The intermediate and the target product are characterized by ¹H NMR, ¹³C NMR and ESI-MS.The synthesis process has advantages of easily obtained raw materials, mild reaction conditions, easy control and high yield, and is suitable for large-scale production

Fenxi Shiyanshi

Determination of related substances in vorapaxar sulfate by RP-HPLC

Author: Bi, Sen ; Ni, Dongsheng ; Sun, Jinglong ; You, Feng ; Zhao, Yixiang

A method for the determination of related impurities in vorapaxar sulfate by HPLC was established.ACE Excel C₁₈ column was used.In gradient elution the mobile phase A was water (adjusted to pH 2.5 with phosphoric acid) and mobile phase B was acetonitrile.The detection wavelength was 260 nm and the injection volume was 20μL.The results showed that the main content and the impurities were well separated, and the known impurities had good linearity (r>0.9996) in the determination range.The method can be used for the quality control of volapaxar sulfate.

100 Deals associated with Nanjing Huawe Medicine Technology Development Co., Ltd.

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100 Translational Medicine associated with Nanjing Huawe Medicine Technology Development Co., Ltd.

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Pipeline

Pipeline Snapshot as of 03 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

3

4

Preclinical

Other

5

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

HW-4102 ( IDO1 )	-	Preclinical
RNA tumor vaccine (Huawe Medicine)	Solid tumor More	Preclinical
HW-CX04 ( PD-1 x PDL1 )	-	Preclinical
HW-CX01 ( HBX )	-	Preclinical
HW-6005 ( AT1R )	-	Discovery