Delving into the Latest Updates on Jilin Aodong Taonan Pharmaceutical Co., Ltd. with Synapse

Overview

Tags

Skin and Musculoskeletal Diseases

Cardiovascular Diseases

Nervous System Diseases

Small molecule drug

Herbal medicine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	3
Herbal medicine	1

Top 5 Target	Count

VMAT2(Synaptic vesicular amine transporter)	1

主要目的：本研究以吉林敖东洮南药业股份有限公司研制的甲磺酸仑伐替尼胶囊为受试制剂，按生物等效性试验的有关规定，以Eisai（Hong Kong）Co.,Ltd.持证的乐卫玛®为参比制剂，进行空腹/餐后状态下人体生物等效性试验，评价受试制剂和参比制剂在健康受试者体内的生物等效性。次要目的：观察受试制剂和参比制剂在健康受试者中的安全性。

[Translation]

Main purpose: This study used lenvatinib mesylate capsules developed by Jilin Aodong Taonan Pharmaceutical Co., Ltd. as the test preparation. According to the relevant regulations of bioequivalence tests, Eisai (Hong Kong) Co., Ltd.'s certified LENVIMA® was used as the reference preparation to conduct human bioequivalence tests in fasting/postprandial states to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: To observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date28 Jun 2024

Sponsor / Collaborator

Jilin Aodong Taonan Pharmaceutical Co., Ltd.

CTR20223359

/ CompletedNot Applicable

甲磺酸仑伐替尼胶囊在健康人体空腹/餐后状态下的生物等效性试验

[Translation] Bioequivalence study of lenvatinib mesylate capsules in healthy volunteers under fasting/fed conditions

主要目的：本研究以吉林敖东洮南药业股份有限公司研制的甲磺酸仑伐替尼胶囊为受试制剂，按生物等效性试验的有关规定，以Eisai（Hong Kong）Co.,Ltd.持证的乐卫玛®为参比制剂，进行空腹/餐后状态下人体生物等效性试验，评价受试制剂和参比制剂在健康受试者体内的生物等效性。次要目的：观察受试制剂和参比制剂在健康受试者中的安全性。

[Translation]

Main purpose: This study used lenvatinib mesylate capsules developed by Jilin Aodong Taonan Pharmaceutical Co., Ltd. as the test preparation. According to the relevant regulations of bioequivalence tests, Eisai (Hong Kong) Co., Ltd.'s certified LENVIMA® was used as the reference preparation to conduct human bioequivalence tests in fasting/postprandial states to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: To observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date27 Dec 2022

Sponsor / Collaborator

Jilin Aodong Taonan Pharmaceutical Co., Ltd.

CTR20220195

/ CompletedNot Applicable

磷酸奥司他韦胶囊在健康人体内的生物等效性试验

[Translation] Bioequivalence study of oseltamivir phosphate capsules in healthy volunteers

主要目的：本研究以吉林敖东洮南药业股份有限公司生产的磷酸奥司他韦胶囊（规格：75mg/粒）为受试制剂，Roche Pharma（Schweiz）AG持证的磷酸奥司他韦胶囊（商品名：Tamiflu®，规格：75mg/粒）为参比制剂，进行空腹/餐后状态下人体生物等效性试验，评价受试制剂和参比制剂在健康受试者体内的生物等效性。次要目的：观察受试制剂和参比制剂在健康受试者的安全性。

[Translation]

Main purpose: This study used Oseltamivir Phosphate Capsules (specification: 75 mg/capsule) produced by Jilin Aodong Taonan Pharmaceutical Co., Ltd. as the test preparation and Oseltamivir Phosphate Capsules (trade name: Tamiflu®, specification: 75 mg/capsule) certified by Roche Pharma (Schweiz) AG as the reference preparation to conduct a human bioequivalence test under fasting/postprandial conditions to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: To observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date17 Feb 2022

Sponsor / Collaborator

Jilin Aodong Taonan Pharmaceutical Co., Ltd.

100 Clinical Results associated with Jilin Aodong Taonan Pharmaceutical Co., Ltd.

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0 Patents (Medical) associated with Jilin Aodong Taonan Pharmaceutical Co., Ltd.

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5

Literatures (Medical) associated with Jilin Aodong Taonan Pharmaceutical Co., Ltd.

01 Aug 2025·Journal of Pharmaceutical and Biomedical Analysis

GC and HPLC-RID method development and validation for the determination of twelve related substances, including several novel compounds in tetrabenazine

Article

Author: Meng, Dong-Shuo ; Sun, Shen-Guo ; Zhu, Tian-Quan ; Ma, Chun-Xin ; Li, Guo-Jing ; Liu, Yu

A series of GC-FID and HPLC-RID methods were developed and rigorously validated for the detection of various aldehyde and ketone impurities, including 5-methyl-2-hexanone and 5-methyl-3-hexen-2-one, as well as quaternary ammonium salt impurity that lack UV absorption, during the synthesis of tetrabenazine. Six novel compounds, three have not been previously reported, were synthesized and their structures confirmed. This was achieved through a comprehensive investigation into impurity transmission chains and their clearance throughout the synthesis process. The limits for all detected impurities, which included a total of twelve related substances, were established at approximately 0.1 %. The LOD for the developed analytical methods ranged from 0.3 μg mL^-1 to 12.5 μg mL^-1.

Zhongguo Laonianxue Zazhi

Efficacy of Qingnaozhitong capsule in treatment of elder patients with migraine

Author: Liu, Hong-yan ; Zeng, Yan ; Zhu, Tian-quan ; Wu, Dan ; Cheng, Zhi-guo ; Sun, Shen-guo

Objective: To explore the efficacy of Qingnaozhitong capsule in treatment of elder patients with migraine.Methods: There were an exptl. group given Qingnaozhitong capsules and a control group given Zhennaoning capsules.The efficacy, Chinese medicine syndrome, vital signs and laboratory examination were observedResults: Comparing with the control group, the efficacy and Chinese medicine syndrome in the exptl. group were superior to those in the control group (P<0.01), and the times and durations of headache were significantly improved (P<0.001 or P<0.05).Conclusions: Qingnaozhitong capsule has effect in treatment of elder patients with migraine.

Zhongguo Yaoshi (Wuhan, China)

Determination of furostanol saponin a in crude saponins from Tribulus terrestris by HPLC

Author: Wu, Dan ; Cheng, Zhiguo ; Zhu, Tianquan ; Sun, Shenguo ; Liu, Wei ; Zeng, Yan

Method for determination of furostanol saponin a in crude saponins from Tribulus terrestris by HPLC was established.The chromatog. conditions were as follow: Diamonsil C¹⁸ column (250 mm × 4.6 mm, 5μm), acetonitrile -water (29:71) as mobile phase, flow rate at 0.7 mL·min^-1, flow rate at 2.0 L·min^-1.There was a good linearity within the range of 1.376∼8.256 μg.The average recovery rate was 100.24% with RSD of 1.6%.The sample contents were 80.8∼107.6 mg·g^-1.This method is reliable, simple and accurate.

100 Deals associated with Jilin Aodong Taonan Pharmaceutical Co., Ltd.

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100 Translational Medicine associated with Jilin Aodong Taonan Pharmaceutical Co., Ltd.

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Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Pipa Qingfei Granules	Acne Vulgaris More	Approved
Deserpidine ( VMAT2 )	Hypertension More	Approved
Acehytisine hydrochloride	Tachycardia More	Approved
Imidazole Salicylate	Arthralgia More	Approved