Neuropathic pain (NP) is a chronic condition caused by damage or disease affecting the somatosensory nervous system and may be associated with abnormal sensations or pain from normally non-painful stimuli. It is usually associated with impaired quality of life (QoL) which can potentially progress to a stage in which the patient is phys. and psychol. distressed and also, the global burden of the disease conditions attributable to neuropathic pain are increasing over the past decade for reasons unknown. This study was conducted to determine the prescribing pattern for neuropathic pain and to assess the improvement and tolerability of the prescribed medications in neuropathic pain.100 consecutive subjects of either gender aged 18-65 years with newly diagnosed neuropathic pain, who attended Pain Super Specialty Outpatient Department at KIMS Hospital and Research Center, Bangalore were assessed for the pattern of drugs prescribed and improvement of pain and overall health was estimated by using Short-Form McGILL Pain Questionnaire. The mean age group of study subjects was 44.68 years, majority of which, were between 31-50 years with more preponderance among male subjects. The response to combination therapy with 1st line drugs were better when compared to monotherapy in effectively managing all the dimensions of pain. The response to NP was higher in subjects with younger age group, good socio-economic status, familial support, good awareness and functional status, regular follow-up visits. Poor response was related to advancing age, lack of family/social support, multiple illnesses and medications and adverse effects.