Delving into the Latest Updates on Haikou Pharmaceutical Co. Ltd. with Synapse

Overview

Tags

Urogenital Diseases

Infectious Diseases

Other Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	3
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Small molecule drug	3

Top 5 Target	Count

PBPs(Bacterial penicillin-binding protein)	2
TGF-β1 x p38γ	1

海口市制药厂有限公司生产的头孢克洛干混悬剂（0.125 g）与苏州西克罗制药有限公司持证的头孢克洛干混悬剂（商品名：希刻劳®，0.125 g）在健康受试者中的单次给药、随机、开放、两周期、双交叉、空腹及餐后状态下的生物等效性研究

[Translation] A single-dose, randomized, open-label, two-period, double-crossover bioequivalence study of cefaclor dry suspension (0.125 g) produced by Haikou Pharmaceutical Factory Co., Ltd. and cefaclor dry suspension (trade name: Xikeluo®, 0.125 g) certified by Suzhou Xikeluo Pharmaceutical Co., Ltd. in healthy subjects under fasting and fed conditions

主要研究目的：以苏州西克罗制药有限公司持证的头孢克洛干混悬剂为参比制剂，以海口市制药厂有限公司生产的头孢克洛干混悬剂为受试制剂，通过单中心、随机、开放、单次给药、两周期、双交叉临床研究进行人体生物等效性研究，为正式试验的研究方案设计提供数据支持。

[Translation]

The main research purpose: Using the certified cefaclor dry suspension of Suzhou Xikro Pharmaceutical Co., Ltd. as the reference preparation and the cefaclor dry suspension produced by Haikou Pharmaceutical Factory Co., Ltd. as the test preparation, a human bioequivalence study was conducted through a single-center, randomized, open, single-dose, two-cycle, double-crossover clinical study to provide data support for the design of the research plan for the formal trial.

Start Date30 Jul 2022

Sponsor / Collaborator

Haikou Pharmaceutical Co. Ltd.

CTR20213016 / RecruitingNot Applicable

氟非尼酮胶囊在肝功能损害受试者的药代动力学和安全性研究（单中心、开放）

[Translation] Pharmacokinetics and safety study of flufenidone capsules in subjects with hepatic impairment (single center, open)

主要目的：比较氟非尼酮胶囊在轻度肝损害受试者和肝功能正常受试者的药代动力学特征。次要目的：评价氟非尼酮胶囊在肝功能损害受试者中的安全性。

[Translation]

Primary objective: To compare the pharmacokinetic characteristics of flufenidone capsules in subjects with mild hepatic impairment and subjects with normal hepatic function. Secondary objective: To evaluate the safety of flufenidone capsules in subjects with hepatic impairment.

Start Date18 Mar 2022

Sponsor / Collaborator

Haikou Pharmaceutical Co. Ltd.

[+1]

CTR20211557 / Active, not recruitingPhase 2

以富马酸丙酚替诺福韦片作为基础治疗，评估不同剂量的氟非尼酮胶囊治疗慢性乙型病毒性肝炎肝纤维化的有效性和安全性的多中心、随机、双盲、安慰剂、平行对照 II 期临床试验

[Translation] A multicenter, randomized, double-blind, placebo-controlled, parallel-controlled phase II clinical trial to evaluate the efficacy and safety of different doses of flufenidone capsules in the treatment of liver fibrosis in chronic hepatitis B using tenofovir alafenamide fumarate tablets as the basic treatment

主要目的：与安慰剂对照，初步评价不同剂量氟非尼酮胶囊治疗慢性乙型病毒性肝炎肝纤维化的有效性。次要目的：初步评价不同剂量氟非尼酮胶囊治疗慢性乙型病毒性肝炎肝纤维化的安全性。

[Translation]

Primary objective: To preliminarily evaluate the effectiveness of different doses of flufenidone capsules in the treatment of liver fibrosis caused by chronic hepatitis B virus infection compared with placebo. Secondary objective: To preliminarily evaluate the safety of different doses of flufenidone capsules in the treatment of liver fibrosis caused by chronic hepatitis B virus infection.

Start Date22 Nov 2021

Sponsor / Collaborator

Haikou Pharmaceutical Co. Ltd.

[+1]

100 Clinical Results associated with Haikou Pharmaceutical Co. Ltd.

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0 Patents (Medical) associated with Haikou Pharmaceutical Co. Ltd.

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1

Literatures (Medical) associated with Haikou Pharmaceutical Co. Ltd.

Zhongguo Yiyuan Yaoxue Zazhi

Application of fluidized bed spray granulation in preparation of Fengliao Changweikang sugar-free capsules

Author: Zhang, Zhilan

The application of fluidized bed spray granulation in preparation of Fengliao Changweikang sugar-free capsules was evaluated by using the orthogonal test.The flue gas temperature and flow, the relative d. of extract and the speed of spraying were determined to screen the optimal technol.The optimal conditions for the preparation of Fengliao Changweikang sugar-free capsules were obtained as follows: the relative d. of extract was 1.25, the flue gas temperature was 80°, the speed of spraying was 40 mL/min, and the gas flow was 1400 m³/h.This method was simple and automated for the present preparation of traditional Chinese medical pharmaceuticals.

100 Deals associated with Haikou Pharmaceutical Co. Ltd.

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100 Translational Medicine associated with Haikou Pharmaceutical Co. Ltd.

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Pipeline

Pipeline Snapshot as of 08 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

1

Phase 2 Clinical

Approved

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Cefoxitin Sodium ( PBPs )	Bacterial Infections More	Approved
Fluorofenidone ( TGF-β1 x p38γ )	Hepatitis B, Chronic More	Phase 2
Cefbuperazone Sodium ( PBPs )	Cholangitis More	Phase 1