Delving into the Latest Updates on Nanjing Normal University with Synapse

Overview

Tags

Neoplasms

Skin and Musculoskeletal Diseases

Nervous System Diseases

Small molecule drug

Monoclonal antibody

Single-chain FV antibody fragment

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	6
Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Immune System Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	3
Monoclonal antibody	2
Recombinant protein	1
AAV based gene therapy	1
Single-chain FV antibody fragment	1

Top 5 Target	Count

LILRB2(Leukocyte immunoglobulin-like receptor subfamily B member 2)	2
SYT7(synaptotagmin 7)	1
LILRB1(Leukocyte immunoglobulin-like receptor B1)	1
FEN1(flap structure-specific endonuclease 1)	1
IL-22(Interleukin-22)	1

This study aims to employ a longitudinal tracking research to investigate the effects of a visual perspective taking intervention on the development of theory of mind in children with autism. Additionally, the investigators seek to examine modifications in the neural mechanisms linked to facial emotion recognition in children both before and after intervention by using the functional Near-Infrared Spectroscopy (fNIRS) to record the relative changes in blood oxygen levels in the cerebral cortex with the oddball Face-Periodic Visual Stimulation (FPVS) paradigm.

Start Date15 Nov 2023

Sponsor / Collaborator

Nanjing Normal University

[+1]

NCT04690465 / CompletedNot ApplicableIIT

Effectiveness of Resistance Training on Resilience in Hong Kong Chinese Older Adults: Study Protocol for a Randomized Controlled Trial

Background: There is on one hand sufficient evidence showing strong association between resilience and self-rated successful aging. On the other hand, strength training could contribute the cultivation of resilience among older adults. Therefore, the current study aims to examine the effectiveness of resistance training on resilience among Chinese older adults in Hong Kong.
Methods: This study will apply a three-group, double blinded (outcome assessors and data analysts), randomized controlled trial (RCT) to examine the effectiveness of the interventions on resilience, functional fitness, and health related quality of life immediately after a 16-week intervention, as well as the residual effects 12 weeks after completion of the interventions.
Discussion: It is expected that resistance training is promising or even superior to aerobic training in the improvement of resilience. Given the limited evidence on the literature, it is urgently needed to explore the effects of resistance training on the improvement of resilience in older adults. Findings of the current study can contribute to the development of effective resistant training programs for the promotion of resilience among older adults.

Start Date30 Jan 2021

Sponsor / Collaborator

Hong Kong Baptist University

[+2]

100 Clinical Results associated with Nanjing Normal University

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0 Patents (Medical) associated with Nanjing Normal University

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33,692

Literatures (Medical) associated with Nanjing Normal University

01 Feb 2025·Separation and Purification Technology

Pilot-scale conditioning of starch-based flocculant for cyanobacterial thickening and dewatering: Mechanism investigation and effect verification

Author: Tang, Yazhou ; Zhou, Wenxiang ; Zhou, Kai ; Li, Yongze ; Yang, Yuchen ; Qi, Chujie ; Bian, Bo

Existing cyanobacteria thickening and dewatering processes in Taihu Lake commonly use conventional inorganic flocculants to condition the cyanobacteria, which poses certain environmental risks.In this study, three different types of typical flocculants, namely polymerized aluminum chloride (PAC), cationic polyacrylamide (CPAM) and starch-based flocculant (St-CTA), were selected to investigate their flocculant effects on cyanobacteria and the mechanism of action.The anal. showed that the dosage of St-CTA was low, the flocculation efficiency was high, and it could form flocs with large particle size and high strength.The adsorption and precipitation effect of St-CTA on protein and polysaccharide in flocculated EPS was stronger than that of CPAM and PAC, and it was able to act on the protein structure of EPS favorable for flocculation, improve the hydrophilic effect of S-EPS and LB-EPS, and reduce the content of bound water in EPS from 2.08 to 1.22 g/g DS, thus improving the efficiency of algae-water separationThe free energy and energy barrier of the EPS surface in each layer of the cyanobacterial floc after flocculation by St-CTA were significantly reduced, which resulted in the tendency of the cyanobacterial particles to aggregate and thus flocculate and settle.The pilot validation of St-CTA for cyanobacteria dewatering showed that the water content of algal residue could be reduced to 93.48 %, and the removal efficiencies of total nitrogen (TN), total phosphorus (TP), ammoniacal nitrogen (NH₃-N), and COD (COD) in the air-floated water could be up to 27.3 %, 76.6 %, 27.4 %, and 56.4 %, resp.In conclusion, this study provides scientific knowledge and demonstration for promoting the use of St-CTA to condition cyanobacterial thickening and dewatering, which is a new idea to solve the problem of cyanobacterial resourcefulness and safe utilization.

01 Jan 2025·Discrete and Continuous Dynamical Systems

Regularity and Liouville theorem on an integral equation of Allen-Cahn type

Author: Chen, Qinghua ; Lei, Yutian

01 Jan 2025·Food Chemistry

Potential prebiotic properties and proliferation mechanism of fermented milk-derived polypeptides

Article

Author: Du, Qiwei ; Guo, Yuqiao ; Cheng, Lu ; Pan, Daodong ; Guo, Yuxing ; Tu, Maolin ; Wang, Feng ; Zeng, Xiaoqun ; Wu, Zhen

The purpose of this paper is to investigate the potential prebiotic properties and proliferation mechanism of fermented milk-derived peptides. In this study, fermented milk-derived polypeptides were obtained by extraction, separation, and purification. The purified peptides were used to culture fecal flora in vitro, and the relative abundance and composition of the flora were analyzed by high-throughput 16S rRNA sequencing technology. The results showed that peptides can promote the proliferation of beneficial bacteria Lactococcus in the intestine and inhibit the proliferation of harmful bacteria Escherichia coli-Shigella. The amino acid sequence of polypeptide components was determined and synthesized in vitro to verify the proliferation of intestinal flora; the proliferation mechanism of peptides on Lactococcus lactis was studied using non-targeted LC-MS metabolomics technology. Five important peptides with molecular weights of 1000-2000 Da were identified by LC-MS: GRP1 (LTEEEK), GRP2 (ENDAPSPVM*K), GRP3 (ITVDDK), GRP4 (EAM*APK) and GRP5 (LPPPEK). The results showed that the peptides could affect the arginine biosynthesis pathway and the amino sugar and nucleotide sugar metabolism of Lactococcus lactis. In addition, the peptides increased the expression of organic acids and their derivatives in Lactococcus lactis. This study provides a research basis for expanding the potential sources of new prebiotics and also opens up a new idea for discovering new prebiotics in vitro.

100 Deals associated with Nanjing Normal University

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100 Translational Medicine associated with Nanjing Normal University

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Pipeline

Pipeline Snapshot as of 26 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

5

3

Preclinical

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

SC13 ( μ opioid receptor )	Breast Cancer More	Preclinical
NNU-546 ( Proteasome )	Multiple Myeloma More	Preclinical
SC13 (Nanjing Normal University) ( FEN1 )	Breast Cancer More	Preclinical
CN115927355 ( SYT7 )	Nutritional and Metabolic Diseases More	Discovery
CN117327178 ( LILRB2 )	Neoplasms More	Discovery