The hypolipidemic effect of monascus and propolis tablet (MPT) on exptl. rats was studied. 50 SD rats were randomly divided into 5 groups: control group, hyperlipidemia model group and low, middle and high dose of monascus and propolis tablet groups (0.17, 0.33, 1.00 g/kg equivalent to 5, 10 and 30 times of the recommended dose of human resp.), each with 10.All the groups were administered with their own test substance by gavage for 6 wk.Compared with the control group, serm total cholesterol (TC), triglyceride (TG), low d. lipoprotein cholesterol (LDL-C) in model group were increased significantly (P<0.01).Compared with the model group, LDL-C level in the serum of rats in middle dose group and TG level in the serum of rats in middle and high dose groups were obviously decreased (P<0.05), the differences were statistically significant.The Monascus and propolis Tablet could decrease the serum lipid level effectively.