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JNK3(c-Jun N-terminal kinase 3)	1

Honey is a complex matrix that contains a wide range of compounds. This rich composition is influenced by diverse environmental factors, including geographic and botanical origin. Honey has been among the most commonly tampered foods worldwide, with improvements in techniques to do it. Accordingly, there is a recurring need for new techniques and methods to assess the honey's metabolic profiles to distinguish adulterated from non-tampered samples. In this sense, this study aimed to determine the chemical profiles of honey samples from the eleven agroecological zones of the Santa Catarina State (southern Brazil), collected in the 2019-2020 and 2020-2021 harvest seasons through 1D- and 2D-NMR. As a result, a series of metabolites was identified and their concentrations measured in samples. Further, the metabolomic dataset was used for building descriptive models through chemometric techniques, in order to discriminate honey samples according to their geographic and botanical origins and harvest season effect. Twenty-one metabolites were identified, with predominance of glucose and fructose in all samples. Two other carbohydrates (sucrose and maltose) were identified in lower concentrations, in addition to amino acids, organic acids, ketone, alcohol, ester, and alkaloids. No discrepant ¹H NMR resonances that could indicate fraud were detected in the spectra. By PCA, it was possible to find clusters with similar geographic origins, i.e., agroecological zones, and botanical origins. In this regard, patterns of composition were detected for honey samples of Eucalyptus spp. and Hovenia dulcis species, which presented acetoin and kynurenate, respectively, in higher concentrations. Taking together, the results allowed demonstrating that NMR spectroscopy coupled to chemometrics is an effective experimental approach to characterize Brazilian honey regarding their geographic origin and season of collection, despite the huge floral diversity available in that country for bee forage.

17 Feb 2025·International Journal of Acarology

Mite diversity of cupuaçu trees ( Theobroma grandiflorum : Malvaceae) in the state of Pará, Amazon, Brazil

Author: da Silva Brito, Edna Antônia ; da Silva Noronha, Aloyséia Cristina ; Silva de Castro, Lury ; Nunes Vinhas, Naiara Antônia ; Juarez Ferla, Noeli

02 Jan 2025·Nutritional Neuroscience

The symptomatology of Attention-Deficit/Hyperactivity Disorder and the genetic control of vitamin D levels

Article

Author: Bau, Claiton Henrique Dotto ; Dresch, Fabiane ; Rovaris, Diego Luiz ; Shansis, Flávio Milman ; Grevet, Eugenio Horacio ; da Silva, Caroline ; Genro, Júlia Pasqualini ; das Neves, Fernando Godoy Pereira ; Bandeira, Cibele Edom ; da Silva, Bruna Santos ; Contini, Verônica ; Dias-Soares, Monique

OBJECTIVESVitamin D deficiency has been associated with psychiatric disorders and behavioral phenotypes such as Attention-Deficit/Hyperactivity Disorder (ADHD). Considering that vitamin D levels are polygenic, we aim to evaluate the overall effects of its genetic architecture on symptoms of inattention, hyperactivity, and impulsivity and on the serum levels of vitamin D in two independent samples of adults, as well as the specific effects of five relevant polymorphisms in vitamin D-related genes.METHODSWe evaluated 870 subjects from an ADHD sample (407 cases and 463 controls) and 319 subjects from an academic community (nutrigenetic sample). Vitamin D serum levels were obtained through Elisa test and genetic data by TaqMan™ allelic discrimination and Infinium PsychArray-24 BeadChip genotyping. Polygenic Scores (PGS) were calculated on PRSice2 based on the latest GWAS for Vitamin D and statistical analyses were conducted at Plink and SPSS software.RESULTSVitamin D PGSs were associated with inattention in the ADHD sample and with hyperactivity when inattention symptoms were included as covariates. In the nutrigenetic sample, CYP2R1 rs10741657 and DHCR7 rs12785878 were nominally associated with impulsivity and hyperactivity, respectively, and both with vitamin D levels. In the clinical sample, RXRG rs2134095 was associated with impulsivity.DISCUSSIONOur findings suggest a shared genetic architecture between vitamin D levels and ADHD symptoms, as evidenced by the associations observed with PGS and specific genes related to vitamin D levels. Interestingly, differential effects for vitamin D PGS were found in inattention and hyperactivity, which should be considered in further studies involving ADHD.

100 Deals associated with Universidade Do Vale Do Taquari

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100 Translational Medicine associated with Universidade Do Vale Do Taquari

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Pipeline

Pipeline Snapshot as of 14 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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